WFS1 (NM_001145853) Human Recombinant Protein

CAT#: TP327925

Purified recombinant protein of Homo sapiens Wolfram syndrome 1 (wolframin) (WFS1), transcript variant 2

Product Images

Coomassie blue staining of purified WFS1 protein (Cat# TP327925). The protein was produced from HEK293T cells transfected with WFS1 cDNA clone (Cat# RC227925) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC227925. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 100.1 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001139325
• Locus ID: 7466
• UniProt ID: O76024, A0A0S2Z4V6
• Cytogenetics: 4p16.1
• Refseq Size: 3636
• Refseq ORF: 2670
• Synonyms: CTRCT41; WFRS; WFS; WFSL
• Summary: 'This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]'
• Protein Families: Druggable Genome, Transmembrane