Mcm3 (BC031700) Mouse Recombinant Protein
CAT#: TP510780
Purified recombinant protein of Mouse minichromosome maintenance deficient 3 (S, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
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Specifications
Product Data | |
Species | Mouse |
Expression Host | HEK293T |
Tag | C-MYC/DDK |
Predicted MW | 91.5 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Reference Data | |
Locus ID | 17215 |
Cytogenetics | 1 A4 |
Refseq Size | 2899 |
Refseq ORF | 2436 |
Synonyms | P1, p1.m |
Summary | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. [UniProtKB/Swiss-Prot Function] |
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