Itga2b (NM_010575) Mouse Recombinant Protein

CAT#: TP522526

Purified recombinant protein of Mouse integrin alpha 2b (Itga2b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Specifications

Product Data

• Species: Mouse
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from Mouse cDNA ORF Clone, MR222526, encoding Mouse full-length Itga2b.
• Tag: C-MYC/DDK
• Predicted MW: 112.7 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_034705
• Locus ID: 16399
• UniProt ID: Q9QUM0
• Cytogenetics: 11 66.29 cM
• Refseq Size: 3437
• Refseq ORF: 3102
• Synonyms: AI172977; alphaIIb; CD41; CD41B; GpIIb
• Summary: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProtKB/Swiss-Prot Function]