NNT1 (CLCF1) (NM_013246) Human Recombinant Protein
CAT#: TP723332
Purified recombinant protein of Human cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 1.
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MLNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF
|
Tag | Tag Free |
Predicted MW | 22.4 kDa |
Concentration | Resuspend the protein in the desired concentration in proper buffer |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2 |
Bioactivity | NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml. |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Storage | Store at -80°C. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_037378 |
Locus ID | 23529 |
UniProt ID | Q9UBD9 |
Cytogenetics | 11q13.2 |
Refseq Size | 1860 |
Refseq ORF | 675 |
Synonyms | BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6 |
Summary | This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2009] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Documents
FAQs |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC402229 | CLCF1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC431793 | CLCF1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY402229 | Transient overexpression lysate of cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 1 |
USD 396.00 |
|
LY431793 | Transient overexpression lysate of cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2 |
USD 396.00 |
|
PH304427 | CLCF1 MS Standard C13 and N15-labeled recombinant protein (NP_037378) |
USD 2,055.00 |
|
TP304427 | Recombinant protein of human cardiotrophin-like cytokine factor 1 (CLCF1) |
USD 439.00 |
|
TP328765 | Purified recombinant protein of Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2. |
USD 748.00 |
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