Neurofascin (NFASC) (NM_001005388) Human Recombinant Protein

CAT#: TP762503

Purified recombinant protein of Human neurofascin (NFASC), transcript variant 1, 928Ala-1096Thr, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein Nfasc186 was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (928Ala-1096Thr) of NFASC
• Tag: N-His
• Predicted MW: 20kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001005388
• Locus ID: 23114
• UniProt ID: O94856
• Cytogenetics: 1q32.1
• Refseq Size: 10351
• Refseq ORF: 3720
• Synonyms: NEDCPMD; NF; NRCAML
• Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)