a (NM_015770) Mouse Untagged Clone

CAT#: MC209853

a (untagged) - Mouse nonagouti (a), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: a
• Synonyms: A; As; ASIP; ASP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC209853 representing NM_015770
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGATGTCACCCGCCTACTCCTGGCCACCCTAGTGGGCTTCCTGTGCTTCTTCACCGTCCACAGCCACC
  TGGCACTCGAGGAGACGCTTGGAGATGACAGGAGTCTGCGGAGTAACTCCTCCATGAACTCGCTGGATTT
  CTCCTCTGTTTCTATCGTGGCACTGAACAAGAAATCCAAGAAGATCAGCAGAAAAGAAGCCGAGAAGCGG
  AAGAGGTCTTCCAAGAAAAAGGCTTCGATGAAGAAGGTGGCAAGGCCCCCGCCACCTTCGCCCTGCGTGG
  CCACCCGCGACAGCTGCAAGCCACCCGCACCCGCCTGCTGCGACCCGTGCGCCTCCTGCCAGTGCCGTTT
  CTTCGGCAGCGCCTGCACCTGTCGAGTACTCAACCCCAACTGCTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_015770
• ORF Size: 396 bp
• Insert Size: 396
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_015770.3, NP_056585.2
• RefSeq Size: 692
• RefSeq ORF: 396
• Locus ID: 50518
• Gene Summary: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth. [UniProtKB/Swiss-Prot Function]