Allergies / Allergic Diseases
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to something in the environment that usually causes little problem in a lot of people.
Many cytokine/chemokine molecules are known to be involved in the allergy reactions. The type 2 immune response is the major protective mechanism against metazoan parasites and is simultaneously characteristic of allergy. In a recent research, the TAM family receptor tyrosine kinase TYRO3 was discovered to limit the magnitude of the immune response against allergens in the context of type 2 immunity. This discovery provides a new therapeutic target for allergic diseases. (Pamela Y. Chan et al. Science.)
OriGene has developed highly specific TYRO3 antibodies for FC, IHC, IF, WB and IP.
TA500415
![TA500415](https://cdn.origene.com/assets/images/antibody/100/ta500415-1-c.jpg)
HEK293T cells transfected with either RC208260 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-TYRO3 antibody (TA500415), and then analyzed by flow cytometry
TA500415
![TA500415](https://cdn.origene.com/assets/images/antibody/100/ta500415-1-p.jpg)
Immunoprecipitation (IP) of TYRO3 by using TrueMAB? monoclonal anti-TYRO3 antibodies (Negative control: IP without adding anti-TYRO3 antibody.)
In general, elevated levels of IgE indicate an increased probability of an IgE-mediated hypersensitivity, responsible for allergic reactions. Learn more about OriGene IgE ELISA Kits.
Common Protein of Interest for Asthma and Allergic Diseases
TYRO3 Periostin Galectin-3 TSLP IL4 IL5RA IL9 IL13 IL17A IL17RA IL22 GM-CSFA list of mAbs for treatment of asthma and AD
![list of mAbs for treatment of asthma and AD](https://cdn.origene.com/images/research/allergic.png)
References
- "The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity." Pamela Y. Chan et al. Science. Apr 2016.