ROR (Receptor Tyrosine Kinase Like Orphan Receptors)

The ROR (Receptor Orphan Receptor) are receptor tyrosine kinases that interact with WNT proteins and play a critical role in development. The ROR family contains two members: ROR1 and ROR2. Both are single-pass transmembrane receptors that bind WNT ligands and activate the downstream ?-catenin-independent signaling.

Recent studies have shown that RORs are generally not expressed/expressed at low levels in adult tissues but un-uniformly expressed in multiple cancers as shown in the table.

ROR1 in cancer

ROR1 overexpression is not only seen in hematological malignancies but also in solid tumors such as cancers of the breast, pancreas, and lung.

ROR1 specific tools:

cDNA
clones Lentiviral
Particles Antibodies
  Recombinant
Proteins OEL controls
(verified WB control) CytoSections
(verified IHC control)

ROR2 in cancer

The role ROR2 in hematological cancers is unclear and needs more studies. Even in other cancers, ROR2 expression is heterogeneous. Its expression is often described as a positive prognostic factor for solid tumors. One of the challenges with ROR2 is that many commercial antibodies display non-specific binding leading to disputable results.

ROR2 specific tools:

cDNA
clones Lentiviral
Particles Antibodies
  Recombinant
Proteins OEL controls
(verified WB control) CytoSections
(verified IHC control)

References:

  1. Menck, K.; Heinrichs, S.; Baden, C.; Bleckmann, A. The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention. Cells 2021, 10, 142.
  2. Klein, U.; Tu, Y.; Stolovitzky, G.A.; Mattioli, M.; Cattoretti, G.; Husson, H.; Freedman, A.; Inghirami, G.; Cro, L.; Baldini, L.; et al. Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells. J. Exp. Med. 2001, 194, 1625?1638.
  3. Rosenwald, A.; Alizadeh, A.A.; Widhopf, G.; Simon, R.; Davis, R.E.; Yu, X.; Yang, L.; Pickeral, O.K.; Rassenti, L.Z.; Powell, J.; et al. Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia. J. Exp. Med. 2001, 194, 1639?1648.

ror img ROR pseudokinase structure



RORs expression in cancer

Cancer Entity Expression
acute lymphocytic leukemia ROR1+
chronic lymphocytic leukemia ROR1+
diffuse large B cell lymphoma ROR1+
follicular lymphoma ROR1+
mantle cell lymphoma ROR1+
marginal zone lymphoma ROR1+
multiple myeloma ROR2+
breast cancer ROR1+
ROR2+
cervical cancer ROR1+
ROR2+
colorectal cancer ROR1+
ROR2+/-
endometrial cancer ROR1+
ROR2+
gastric cancer ROR1+
ROR2-
glioblastoma ROR2+
lung cancer ROR1+
ROR2+
melanoma ROR1+
mesothelioma ROR1+
ROR2+
ovarian cancer ROR1+
ROR2+/-
sarcoma ROR2+
pancreatic cancer ROR1+
ROR2+
prostate cancer ROR2-