Biosimilars

Biosimilars are biological compounds, almost identical to a reference biologic drug that have been approved by the U.S. Food and Drug Administration for medical treatment. Research-grade biosimilars are research tools for analysis of biological processes without the need to purchase expensive therapeutic-grade biologics.

List of research grade biosimilars

5T4 (GEN-1044) 5T4 (H8) B7-H3 (CD276, Enoblituzumab) BTN3A1 (ICT 01) CCR2 (Plozalizumab) CD166 (Praluzatamab) CD33 (Gemtuzumab) CD38 (Daratumumab) CD47 (Magrolimab) CD70 (Vorsetuzumab) CGRPR (Erenumab)

CLDN18.2 (Zolbetuximab) GPRC5D (Talquetamab) GUCY2C (Indusatumab) HTRA1 (Galegenimab) FCRL5 (Cevostamab) ICOS (Vopratelimab) IL6 (Siltuximab) IL3RA (Talacotuzumab) KIR2DL2 (Lirilumab) KLRG1 (Ulviprubart) LILRB2 (MK-4830)

Nectin-4 (Enfortumab) NKG2A (Monalizumab) PD-L1 (CD274, Atezolizumab) PD1 (PDCD1, Pembrolizumab) SLAMF7 (Elotuzumab) S Protein (CB6) S Protein (CR3022) Syndecan 1 (Indatuximab ravtansine) TIM3 (HAVCR2, Cobolimab)

Challenge in biosimilar research: One of the critical challenges in analyzing impact of biosimilars is getting a validated positive control for in-situ analysis. It is especially challenging when these projects involve mutant proteins. Not only is the sample inconsistent in staining but are in short supply.

CytoSections are FFPE sections of HEK293T cell pellet that over-expresses targeted proteins. These cells are obtained by transfection of a sequenced verified cDNA clones transfected into HEK293T cells and the expression is verified by western blot and IHC analysis. Learn more about CytoSections?here.

List of other tools for biosimilar research:

Biosimilar	Purified Recombinant Protein (positive control for ELISA)	CytoSection (positive control for IHC)	Additional tools
5T4 GEN-1044	Purified protein	CytoSection	Other research tools
5T4 H8	Purified protein	CytoSection	Other research tools
B7-H3 (CD276) Enoblituzumab	Purified protein	CytoSection	Other research tools
BTN3A1 ICT 01	Purified protein	CytoSection	Other research tools
CCR2 Plozalizumab	Purified protein	CytoSection	Other research tools
CD166 Praluzatamab	Purified protein		Other research tools
CD33 Gemtuzumab	Purified protein	CytoSection	Other research tools
CD38 Daratumumab	Purified protein	CytoSection	Other research tools
CD47 Magrolimab	Purified protein	CytoSection	Other research tools
CD70 Vorsetuzumab	Purified protein	CytoSection	Other research tools
CGRPR Erenumab	Purified protein	CytoSection	Other research tools
CLDN18.2 Zolbetuximab	Purified protein		Other research tools
FCRL5 Cevostamab	Purified protein		Other research tools
GPRC5D Talquetamab	Purified protein	CytoSection	Other research tools
GUCY2C Indusatumab	Purified protein	CytoSection	Other research tools
HTRA1 Galegenimab	Purified protein	CytoSection	Other research tools
ICOS Vopratelimab	Purified protein	CytoSection	Other research tools
IL3RA Talacotuzumab	Purified protein	CytoSection	Other research tools
KIR2DL2 Lirilumab	Purified protein	CytoSection	Other research tools
KLRG1 Ulviprubart	Purified protein	CytoSection	Other research tools
LILRB2 MK-4830	Purified protein	CytoSection	Other research tools
Nectin-4 Enfortumab	Purified protein	CytoSection	Other research tools
NKG2A Monalizumab	Purified protein	CytoSection	Other research tools
IL-6 Siltuximab	Purified protein	CytoSection	Other research tools
PD1 (PDCD1) Pembrolizumab	Purified protein	CytoSection	Other research tools
PD-L1 (CD274) Atezolizumab	Purified protein	CytoSection	Other research tools
S Protein CB6	Purified protein		Other research tools
S Protein CR3022	Purified protein		Other research tools
SLAMF7 Elotuzumab	Purified protein	CytoSection	Other research tools
Syndecan 1 Indatuximab Ravtansine	Purified protein	CytoSection	Other research tools
TIM3 Cobolimab	Purified protein	CytoSection	Other research tools