Breast Cancer Research Tools

At OriGene, we understand the complexity of breast cancer research. That's why we've curated a comprehensive suite of cutting-edge tools meticulously designed to empower researchers, clinicians, and scientists in their pursuit of deeper insights, effective therapies, and breakthrough discoveries. We offer the following research tools:

• cDNA Clones: For over-expression studies, functional analysis, & protein production. View More.
• Clone Sets: For high-throughput screening and pathway studies. View More.
• Antibodies: For immunohistochemistry, western blotting, and immunofluorescence assays. View More.
• Recombinant Proteins: For studying protein-protein interactions studies, biochemical assays, and biomarker identification. View More.
• MicroRNA: For investigating miRNA involvement in breast cancer progression, metastasis, and as potential therapeutic targets. View More.
• siRNA Oligo Duplexes: For transient gene knockdown studies. View More.
• shRNA Plasmid Kits: For long-term gene silencing studies, loss-of-function experiments, and creating stable cell lines for research. View More.
• Transduction-Ready Viral Particles: Lenti & AAV available for delivering genetic material to cells that are hard to transfect (i.e. Stem Cells). View More.
• CRISPR Knockout Kits: For precise gene knockout studies, loss-of-function studies, and creating stable cell lines for research. View More.
• Tissues: For histological analysis, protein analysis, and drug screening studies. View More.

Popular Breast Cancer Gene Targets

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

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cDNA Clones for Breast Cancer Research

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the plasmids we offer for your research.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Species Human Mouse Rat

Tags mGFP Myc-DDK Tag Free TurboGFP

Mammalian Cell Selection Neomycin None Puromycin

Don't see what you're looking for? Check out our custom cloning service here.

Featured Brand – TrueORF® Gold Plasmids

OriGene’s TrueORF® Gold plasmids are an invaluable resource in genetic research. With a selection of over 18,000 meticulously curated plasmids tailored for human genes, these clones epitomize reliability and accuracy. Each clone undergoes stringent validation processes, including expression validation and sequence verification, ensuring their fidelity and functionality. These clones are also available with next-day shipping, allowing researchers to save time and start their experiments as soon as possible!

Furthermore, OriGene's comprehensive catalog of clones have earned the trust of researchers worldwide, gathering over 10,000 citations. View citations.

p53 (TP53) (NM_000546) Human Tagged ORF Clone

Anti-TP53 mouse monoclonal antibody ([TA502870]) immunofluorescent staining of COS7 cells transiently transfected by our TrueORF Gold TP53 plasmid ([RC200003]).

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Clone Sets for Breast Cancer Research

OriGene offers a diverse array of clone sets comprising of sequence-verified and expression-ready clones. Researchers studying the complexities of breast cancer can utilize these clone sets to study gene pathways involved in tumorigenesis and disease progression. Pre-assembled clone sets and custom options are available.

Pre-Assembled Clone Sets

Gene Families	SKU	Description	Layout
Transcription Factors	TCTF101	Human transcription factors clone set I, containing 90 cDNA clones in mammalian expression vector
	TCTF102	Human transcription factors clone set II, containing 90 cDNA clones in mammalian expression vector
Protein Kinases	TCPK101	Human protein kinases clone set I, containing 90 cDNA clones in mammalian expression vector
	TCPK102	Human protein kinases clone set II, containing 90 cDNA clones in mammalian expression vector
GPCR	TCGR101	Human GPCR clone set I, containing 90 cDNA clones in mammalian expression vector
	TCGR102	Human GPCR clone set II, containing 90 cDNA clones in mammalian expression vector
Secreted	TCSP101	Human secreted gene clone set I, containing 90 cDNA clones in mammalian expression vector
	TCSP102	Human secreted gene clone set II, containing 90 cDNA clones in mammalian expression vector
Transmembrane	TCTM101	Human transmembrane clone set I, containing 90 cDNA clones in mammalian expression vector
	TCTM102	Human transmembrane clone set II, containing 90 cDNA clones in mammalian expression vector

Create Your Own Clone Sets by Selecting from a Pre-selected Pathway List

Request a quote!

Gene Families	TrueORF (Myc-DDK Tagged)	TrueClone (Untagged)
Breast Cancer	View List	View List
Breast Cancer & Estrogen Receptor Signaling	View List	View List
MAP Kinase Signaling Pathways	View List	View List
MAPK Cascade	View List	View List
MAPK signaling pathway KEGG	View List	View List
p38 MAPK signaling pathway	View List	View List
P53	View List	View List
p53 Signaling Pathway	View List	View List
Regulation of Actin Cytoskeleton KEGG	View List	View List
Tumor Metastasis	View List	View List

View more pathway lists here.

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Antibodies for Breast Cancer Research

Our antibody portfolio ensures specificity and reliability in diverse applications, from immunohistochemistry to immunofluorescence, western blots and more. Explore our catalog to discover essential tools for your breast cancer research journey.

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the antibodies we offer for your research.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Conjugates Unconjugated Biotin HRP FITC PE TRITC Texas Red AP APC Alkaline Phosphatase Alexa Fluor 488 Magnetic Beads Alexa Fluor 647 Alexa Fluor 546 PerCP MMAE His Tag PE-Cy7 Phycoerythrin Cy5 APC-Cy7 ATTO 550 ATTO 594 ATTO 647N ATTO 425 ATTO 532 ATTO 655 Agarose ATTO 488 Peroxidase APC-Cy5.5 DyLight 488 PE-Cy5.5 PE-TXRD DM1 Cy3 PE-DL594 Dxd Sepharose DyLight 550 DyLight 594 Rhodamine BGAL BIMA DTAF DyLight 633 PE-Cy5 TAMRA

Reactivities Human Mouse Rat Monkey Dog Bovine Canine Porcine Rabbit Pig Chicken Cow Hamster Cynomolgus Primate SARS-CoV-2 Sheep Zebrafish Xenopus Feline Guinea Pig Mammalian Equine Chimpanzee Goat Horse Rhesus Monkey Gorilla Bat Gibbon Escherichia coli Other (Wide Range) Drosophila Influenza A Virus X. tropicalis Macaque All Species Yeast C. elegans HIV Human Immunodeficiency Virus 1 Hepatitis B Virus Orang-Utan Bakers Yeast Fish Vertebrates Broad Bacteria Hepatitis C Virus Virus Borrelia burgdorferi SARS-CoV Ferret Amphibian Baboon Duck Bacillus sp. Respiratory Syncytial Virus Schistosoma japonicum Helicobacter pylori Tomato Cytomegalovirus Influenza B Virus Frog Staphylococcus aureus Mink Streptococcus Pyogenes A. victoria Adenovirus 2 Chlamydia trachomatis Saccharomyces cerevisiae Ape Arabidopsis Candida Opossum Epstein Barr Virus Mycobacterium tuberculosis Adenovirus 5 Aspergillus Birds RFP West Nile Virus Adenovirus Canis Enterobacter Human Alphaherpesvirus 1 Human Alphaherpesvirus 2 Penicillium Streptococcus sp. mCherry rRFP Mouse IgG Streptomyces avidinii Turkey Aspergillus niger Clostridium botulinum Donkey Pollen Salmonella species Adenovirus 8 Clostridium difficile Insect Plant African clawed frog Geodia cydonium Gerbil Golden Syrian Hamster Legionella pneumophila Mustelid Pigeon Alcaligenes Bacillus amyloliquefacies Bacillus species Carica papaya Jack Bean Lactococcus lacti Maize Marmoset Rhizopus Adenovirus 3 Avian Bacterial Brevibacterium Leuconostoc Leuconostoc mesenteroides Mycoplasma pneumoniae Neisseria gonorrhoeae Photinus pyralis Rabbit IgG Rotavirus Streptococcus Treponema pallidum dsRed tdTomato Adenovirus 1 Adenovirus 6 Broad Range Campylobacter jejuni Canavalia ensiformis (Jack Bean) Chlamydia pneumoniae Cucurbita Deer Feline Leukemia Virus Goat IgG Hepatitis A Virus Human Herpesvirus 6 Kangaroo Murine Non-human primates Photobacterium fischerii Rabies Lyssavirus Snake Streptococcus pneumoniae Trichomonas vaginalis Vaccinia virus AAVPHP.B Clostridium histolyticum Clostridium tetanis Corynebacterium diphtheriae Cryptosporidium parvum Ebola virus Giardia lamblia Huaiyangshan-Virus Human Parainfluenza Viruses 1 Lima Bean Listeria monocytogenes Myrothecium Puumala Virus Quail Rat IgG Reptiles Rift Valley Fever Virus Rubella Virus Soy Bean Sweet Potato Toxoplasma gondii Yellow Fever Virus Adenovirus 14 Adenovirus 31 Adenovirus 4 Adenovirus 40 Adenovirus 41 Adenovirus 9 Beluga Bordetella pertussis BrdU Burkholderia Candida species Carp Chlamydia psittaci Clostridium kluyveri Corynebacterium sp Dengue Virus Types 2 Enterobacter cloacae Feline Immunodeficiency Virus Fruit fly GFP Hantaan Virus Horseradish Peroxidase Horsereddish Human IgG Human Immunodeficiency Virus 2 Human Parainfluenza Viruses 3 Human coronavirus HKU1 Human coronavirus OC43 Hydra Kaposi-Sarkom-Herpesvirus Lactobacillus leichmannii Leishmania donovani M13 Bacteriophage Microbial Micrococcus luteus Myrothecium verrucaria Nebraska Calf Diarrhoea Virus Neisseria meningitidis P. testosteroni Plasmodium falciparum Protozoa Rhodopseudomonas spheroides Sin Nombre orthohantavirus Strep-tag II Streptomyces Tobacco Ustilago maydis Vibrio cholerae Zika-Virus var. Adenovirus 10 Adenovirus 13 Adenovirus 18 Adenovirus 7 Andes orthohantavirus Arabidopsis thaliana Bacillus Anthracis Bacteriophage P1 Biotin Bonito Borrelia afzelii Borrelia burgdorferi B31 Bovine Adenovirus 1 Bovine Coronavirus Brugia malayi Burkholderia cenocepacia Canine Adenovirus 1 Canine Distemper Virus Clostridium tetani Coral Cucumber Necrosis Virus Dengue Virus Types 1 Dengue Virus Types 3 Dengue Virus Types 4 Dengue virus FITC Feline Calicivirus Feline Coronavirus Feline Infectious Peritonitis Virus Fungi Gram Positive Bacteria HBA1c HPV11 Haemophilus influenzae Heartland Virus Human IgA Human IgM Human Papilloma Virus 16 Human Parainfluenza Viruses 2 Human coronavirus 229E IdU Invertebrate Japanese Encephalitis Virus Klebsiella pneumoniae MERS-CoV Measles Virus Mouse IgM Mycobacteria Mycobacterium smegmatis N-term and C-term DDK Norovirus Plasmodium berghei Pseudomonas aeruginosa Pseudomonas fluorescens Pufferfish Ricinus communis Roseburia hominis Salmonella Typhimurium Salmonella enteritidis Species independent Specific for blue colour used in protein MW markers Squirrel St. Louis Encephalitis Virus Streptomyces chromofuscus Streptomyces griseus Trout Tuna Yersinia enterocolitica 5-FAM Adenovirus 11 Adenovirus 20 Adenovirus 26 Adenovirus 7a Algal Alligator Arthrobacter globiformis Athrobacterium ureafaciens Bacillus cereus Bacillus subtilis Bear Beta Galactosidase [E.coli] Bison Campylobacter venerealis Canine Coronavirus Cellulomonas Chinese Hamster Chlamydomonas CldU Clostridium chauvoei Clostridium novyi Clostridium perfingens Clostridium septicum Clostridium sordellii Cod Coxsackievirus 16 Digoxin Dogfish Drosophila melanogaster Edwardsiella tarda Enterobacter cloacea Enterococcus species Enterovirus 71 Eukaryote Feline Herpes Virus1 Fungus Gram Negative Bacteria Hagfish Human Astrovirus Human Ig light chain Human IgA1 Human IgA2 Human IgD Human IgE Human IgG1 Human IgG3 Human IgG4 Human Papilloma Virus 1 Human Papilloma Virus 18 Human Papilloma Virus 2 Human Papilloma Virus 3 Human coronavirus NL63 Human gamma heavy chain Human kappa light chain Human lambda light chain Kaposi's Sarcoma-associated herpesvirus La Crosse encephalitis virus Lamprey Leptospira biflexa Llama Medaka fish Mouse Ig kappa light chain Mouse IgG gamma Mouse IgG1 Mouse IgG2a kappa Mouse IgG2b Mouse IgM lambda light chain Mouse IgM mu-chain Mycobacterium avium Mycoplasma bovis Mycoplasma hominis Newcastle Disease Virus Paramecium Bursaria Chlorella Virus 1 Plasmodium knowlesi Potoroo Proteus species Rabbit IgG Fab Rabbit IgG Fc Rhizopus Arrhizus Rice yellow mottle virus Salmon Salmonella paratyphi Salmonella typhi Salmonid Schistosoma mansoni Sea Urchin Seoul Virus Shigella boydii Shigella dysenteriae Shigella flexneri Shigella sonnei Silk Worm SimianIVE Snail Sole Spinach Staphylococcus avidinii Staphylococcus epidermidis Streptococcus sobrims Streptomyces species Streptomyces tsukubaensis Tadpole Tickborne encephalitis virus Tobacco hornworm Transmissable Gastroenteritis Virus Tree Shrew Trichinella spiralis Trichomonas foetus Triticum aestivum Trypanosoma brucei Trypanosoma cruzi Whale White Fly Widely Range Wolffish Yersinia pestis Zea mays

Applications WB IHC IF FC ELISA IP ICC/IF FN FACS Animal Model Kinetics ID LMNX R 10k-ChIP ICC ChIP Bl Neutralize Simple Western Dot CT PEP-ELISA Immunoblotting Protein Purification E SISCAPA CyTOF-ready LF EM ChIP-seq AP AGG EMSA Electron Microscopy Block/Neutralize Inhib Ie SDS-PAGE Elispot ISH P Immuno-affinity-chromatography MeDIP dsRNA-immunoblotting C MC SB CLIA ChIP/ChIP-seq EIA Func IA RIP Sandwich ELISA hMeDIP FISH GST-pull down H Labeling MA MeDIP-seq Protein Array RNAi

Don't see what you're looking for? Check out our custom antibody development service here.

Featured Brand – UltraMAB® Antibodies

UltraMAB® antibodies ensure unparalleled specificity and accuracy. These ultra-specific antibodies are validated against over 17,000 human antigens using a high-density protein microarray, ensuring that there is limited cross reactivity. View details of High-Density Protein Microarray.

OriGene's antibodies have made a significant impact in scientific research, reflected by their extensive citation in academic literature. With over 9,000 citations, OriGene's antibodies have become a cornerstone in diverse fields of study, including but not limited to oncology, immunology, neuroscience, and developmental biology. View citations.

CD44 Mouse Monoclonal Antibody [Clone ID: UMAB134]

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD44 mouse monoclonal antibody. ([UM500099]; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min) (1:500).

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Protein Biomarkers for Breast Cancer Research

Powered by our TrueORF® human cDNA clones, OriGene offers full-length human proteins expressed in HEK293 cells and other systems. These proteins serve as indispensable positive controls in ELISA and antibody assays focused on breast cancer markers, ensuring the reliability and precision of experimental outcomes in studying this complex disease. Furthermore, OriGene's recombinant proteins facilitate investigations into protein-protein interactions specific to breast cancer-related pathways, shedding light on critical mechanisms driving the disease.

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the proteins we offer for your research.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Tags C-Myc/DDK His-tag C-His N-His Tag Free C-Fc N-GST and C-His C-6His C-Human Fc C-DDK C-6×His N-GST and C-HIS C-HIS N-GST C-DDK/His Myc-DDK C-His-Avi C-Fc&His C-FLAG N-6His C-Mouse Fc N-His-ABP N-Human Fc C-mFc N-His-SUMO C-Fc-Avi N-His&C-His His-Tag C-6His-Avi C-8His C-Mouse Fc and 6×His T7-tag C-hFc N-T7&C-His N-Trx&His C-Avi-6His N-His-Trx C-Human Fc and 6×His C-10His N-Fc N-GST, C-His N-HIS N-His&SUMO hIgG-His-tag hIgG-His-Tag C- 6×His N-6×His N-GST&His C-6xHis C-Avi&6His hIgG-Tag C-AVI&His C-Fc&AVI N-8His N-Avi N-His PDCD1 N-His/DDK N-Mouse Fc and C-6×His C-6×His tag and C-Human Fc C-TEV-8His C-mouse Fc His-Cam-tag His-MBP-tag N-6His-Avi N-His&C-Fc N-His&T7 N-His-GST N-MARI N-Trx C-Fc/His C-Flag C-hFc&His His-tagged, myc-tagged N-DDK N-His&Flag N-mFc C-3×Flag Tag C-6xHis/AVI C-7×His C-Avi&His C-DDK-His C-FC C-Fc-Flag&C-Fc-6His C-HUMAN C-Myc-DDK CaM-tag Calmodulin-tag Fc chimera Myc-His-tag N-6His-Flag N-6xHis/AVI N-8His&N-FLAG N-FC N-FLAG N-Fc-FLAG N-GFP N-His-PDCD1 N-Mouse Fc N-TrxA N-terminal His N-terminal His-PDCD1 TrxA C-AVI C-AVI-PLUS C-Avi-10His C-Avi-His C-DDK/10xHis C-DDK/6xHis C-FC-6HIS&C-FC-Flag C-FC/6xHis C-FLAG-6His C-FLAG-Fc C-Fc Human C-Fc Mouse C-Flag,C-6His C-GST C-HIS/C C-HIS/DDK C-His&AVI C-His&Flag C-His&HA&AVI C-His/AVIplus C-Human Fc, Avi C-Human Fc-Avi C-MIgG2a C-hIgG1 Fc C-hIgG2 Fc C-hIgG4 Fc C-hIgG4P Fc C-mFC C-mFc&His C-mIgG2AFc C-mIgG2a Fc C-terminal DDK DDK-tag His tag N-10*His N-10His N-10His-Flag N-6His&Avi N-6His, C-6His N-6His-FLAG N-6xHis N-8His-Flag N-AVI N-AVI&His N-Avi&6His N-BBP&His N-DDK/His N-FUSION N-Flag&C-His N-Flag&His N-GST N-HIS and C-AVIPLUS N-His&MBP N-PROTEIN N-T7 N-TRX N-TRXA N-Trx-His N-hFc N-terminal His-tag N-terminal murine Fc Tag No

Expression Host HEK293T E. coli HEK293 CHO Sf9 Insect Pichia pastoris Baculovirus Pichia Hi-5 insect S. cerevisiae Mouse Other Sf9 insect human serum A549 COS7 H. vulgare HeLa-229 Human Mammalian Yeast

Don't see what you're looking for? Check out our custom protein service here.

Featured Brand – MVPro® Proteins

MVPro® proteins are full-length, recombinant human proteins expressed in HEK293T cells. Their properties are very close to native proteins, making them idea for antibody development, immuno-assays, & structure-function studies.

OriGene recombinant proteins have been mentioned in over 1,400 citations, a testament to their reliability and widespread recognition within the scientific community. This wealth of citations underscores the pivotal role our proteins play in advancing scientific exploration and innovation. View citations.

Estrogen Receptor 1 (ESR1) (NM_000125) Human Recombinant Protein

Coomassie blue staining of purified ESR1 protein (Cat# [TP313277]). The protein was produced from HEK293T cells transfected with ESR1 cDNA clone (Cat# [RC213277]) using MegaTran 2.0 (Cat# [TT210002]).

MicroRNA in Breast Cancer ^[1]

microRNAs are small non-coding RNA molecules that play a significant role in regulation of gene expression via RNA silencing and post-transcriptional regulation pathways. In breast cancer, differential expression of miRNA plays a critical role in regulating the invasion process by influencing cytoskeletal structure, cell-cell adhesion junctions, cancer cell-ECM interaction, tumor microenvironment, EMT transition and cancer stem cell abilities. Understanding miRNA's role in breast cancer will enable a better management of breast cancer metastasis.

Human miRNAs in breast cancer:

Up regulated:

hsa-miR-21 hsa-miR-29b hsa-miR-155

Down regulated:

hsa-miR-10b hsa-miR-125 hsa-miR-14

Refer to the table below for a list of all microRNAs involved in breast cancer

Name of miRNA	miRNA expression pattern	Target Genes affected by miRNA	miRNA Role in Invasion-Metastasis Cascade
miR-142-3p	UP	ITGAV, WASL, RAC1, CFL2	Cancer cell invasiveness inhibition
miR-495	UP	JAM-A	Cancer cell migration
miR-10b	UP	HOXD10	Cell migration and invasion
miR-373	UP	ITGA2	Cell migration, metastasis
miR-103/107	UP	DICER1	EMT, cell migration, metastasis
miR-661	UP	NECTIN1, STARD10	EMT, invasion
miR-221/222	UP	TRPS1	EMT, invasion and migration (basal-like BC)
miR-23a	UP	CDH1	EMT, metastasis
miR-374a	UP	WIF1, PTEN, WNT5A	EMT, metastasis
miR-22	UP	TET1-3	EMT, stemness
miR-155	UP	RHOA	EMT, tight junction dissolution, migration and invasion
miR-191/425	UP	DICER1	Invasion and metastasis
miR-221	UP	CDH1	Invasion and metastasis
miR-221	UP	DNMT3B	Pluripotency and stemness
miR-21	UP	TPM1	Tumor growth and malignant phenotype
miR-145	DOWN	JAM-A	Cancer cell motility inhibition
miR-145	DOWN	JAM-A	Cancer cell motility inhibition
miR-198	DOWN	CDCP1	Cell adhesion and migration inhibition
miR-154	DOWN	ADAM9	Cell migration and invasion inhibition
miR-200a	DOWN	CX43	Cell migration and metastasis inhibition
miR-206	DOWN	CX43	Cell migration and metastasis inhibition
miR-181a-5p	DOWN	MMP14	Cell migration inhibition
miR-539	DOWN	LAMA4	Cell migration inhibition (TNBC)
miR-7	DOWN	PAK1	Cell motility and invasiveness inhibition
miR-494	DOWN	PAK1	Clonogenic ability and cell migration, invasion and metastasis inhibition
miR-29b	DOWN	VEGFA, ANGPTL4, PDGF, LOX, MMP9	EMC re-modeling and metastasis inhibition
miR-200c	DOWN	ZEB1, TKS5, MYLK	EMT and invadopodia forming inhibition
miR-153	DOWN	MTDH	EMT and invasion inhibition
miR-124	DOWN	SNAI2	EMT and metastasis inhibition
miR-200b	DOWN	FERMT2	EMT and metastasis inhibition
miR-34	DOWN	SNAI1	EMT inhibition
miR-205	DOWN	ZEB1, ZEB2	EMT inhibition
miR-375	DOWN	SHOX2	EMT inhibition
miR-506	DOWN	SNAI2, VIM, CD151	EMT, adhesion, invasion, and migration inhibition
miR-30a	DOWN	ZEB2	EMT, invasion and distal spreading inhibition (TNBC)
miR-203	DOWN	SNAI1	EMT, invasion and metastasis inhibition
miR-34c	DOWN	NOTCH4	EMT, migration and self-renewal inhibition
miR-320	DOWN	ETS2	Inhibition of tumor micro-environment re-programming
miR-200 cluster	DOWN	WAVE3	Invasion and cell migration inhibition
miR-33a	DOWN	ADAM9	Invasion and metastasis inhibition
miR-193b	DOWN	uPA	Invasion and metastasis inhibition
miR-335	DOWN	TNC, SOX4	Invasion and metastasis inhibition
miR-720	DOWN	TWIST1	Invasion and metastasis inhibition
miR-126	DOWN	ADAM9	Invasion inhibition
miR-181a	DOWN	uPA	Invasion inhibition
miR-193a/b	DOWN	uPA	Invasion inhibition
miR-221/222	DOWN	ITGB4, STAT5A, ADAM17	Invasion inhibition (luminal BC)
miR-224	DOWN	CDC42, CXCR4	Invasion, metastasis inhibition
miR-31	DOWN	WAVE3	Invasive phenotype reduction
miR-126	DOWN	CXCL12	Metastasis inhibition
miR-124a	DOWN		Proliferation and metastasis inhibition
miR-708	DOWN	LSD1	Proliferation, invasion inhibition
miR-30	DOWN	UBC9	Self-renewal
let-7	DOWN	H-RAS, HMGA2	Self-renewal, stemness
miR-590	DOWN	SOX2	Stemness
miR-140	DOWN	SOX2	Stemness, self-renewal
miR-183 cluster	DOWN	BMI1	Stemness, self-renewal

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References

1. MicroRNAs contribute to breast cancer invasiveness, Fridichova et al., Cell, 2019

siRNA Kits for Breast Cancer Research

OriGene's siRNA kits provide researchers with a comprehensive and efficient toolkit for targeted gene silencing and exploration. Each siRNA kit contains three unique 27mer siRNA duplexes (2 nmol each), a negative control, and dedicated buffer for seamless experimentation. There is also guaranteed knockdown of at least 70%!

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the siRNA kits we offer for your research.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Species Mouse Human Rat

Bulk Order Options

If you purchased our kits and already know which one works best for your gene, you can order this single siRNA in bulk by submitting a bulk request form. Each 10 nmol of single siRNA duplex is charged for $375. Delivery time is around 2 weeks.

Single siRNA Bulk Request

Popular siRNA Kits for Breast Cancer Research

BRCA1 HER2 CHEK2 STK11 P53

shRNA Kits for Breast Cancer Research

Explore our HuSH-29^TM shRNA Kits, engineered to deliver guaranteed knockdown efficiency of over 70% for each target gene. Available in both lentiviral and retroviral vectors, these comprehensive kits empower researchers with tailored solutions for effective gene silencing. Each kit features four distinct 29mer shRNA constructs designed for precise and robust knockdown, alongside a scramble control for reliable experimental validation.

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the shRNA kits we offer for your research.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Species Mouse Human Rat

Reporters GFP None RFP

Don't see what you're looking for? Check out our custom shRNA service here.

Transduction-ready Viral Particles Breast Cancer Research

Lentivirus and AAV (Adeno-associated virus) Particles

Viral particles are tools frequently used to deliver genetic material into cells. Lentiviral particles (LV) and adeno-associated viral particles (AAV) can deliver genetic material into dividing and non-dividing cells unlike other retroviral vectors. These two vectors remain the most popular options for gene delivery in both research and clinical application. OriGene offers pre-made, transduction-ready particles for popular genes in breast cancer research.

Lentivirus Product Format: 200ul; 10^7 TU/mL

AAV Product Format: 250ul; 10^13 GC/mL

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the viral particles we offer for your research.

• Lentivirus Particles
• AAV Particles

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Species Human Mouse Rat

Tags mGFP Myc-DDK Tag Free TurboGFP

Mammalian Cell Selection Neomycin None Puromycin

Don't see what you're looking for? Check out our custom lentivirus service here.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Species Human Mouse Rat

Tags mGFP Myc-DDK Tag Free TurboGFP

Mammalian Cell Selection Neomycin None Puromycin

Don't see what you're looking for? Check out our custom aav service here.

Popular Lentivirus Particles for Breast Cancer Research

PD-L1 Human Tagged ORF Clone Lentiviral Particle

Her2 Human Tagged ORF Clone Lentiviral Particle

PADI2 Human Tagged ORF Clone Lentiviral Particle

CRISPR Knockout Kits for Breast Cancer Research

Our CRISPR Knockout Kits offer an efficient and reliable solution for researchers investigating gene function and disease mechanisms. These kits are easy to use and come with all the necessary components for successful gene editing, including pre-designed guide RNAs and vectors. Browse this collection of over 44,000 kits today!

Directions: Enter your gene name and select one item from each dropdown option, then press submit to view the knockout kits we offer for your research.

ALDH1 AR ATM BARD1 BRCA1 BRCA2 BRIP1 Cadherin CASP8 Caveolin CD44 CDH1 CHEK2 Claudin CTLA4 CYP19A1 Cytokeratin EGFR ESR1 FGFR2 GRB7 H19 HER2 LSP1 MAP3K1 MRE11A MUC1 NBN P53 PALB2 PGR PTEN RAD51 RAD51C RAD51D

Species Mouse Human

Don't see what you're looking for? Check out our custom CRISPR service here.

Tissues for Breast Cancer Research

OriGene's TissueScan cDNA arrays stand as pillars in breast cancer research, widely acknowledged and cited for their pivotal role in advancing scientific understanding (View citations). These arrays, encapsulating Tissue qPCR Arrays, offer panels of pre-normalized cDNA derived from a diverse array of cancer tissues, typically encompassing 48 samples across various disease stages.

Accompanied by comprehensive pathology reports, each array provides a holistic view of disease progression within specific tissue types. Through the design of gene-specific or SNP-specific primers, researchers can leverage a single real-time PCR reaction to unveil critical insights, including the dynamics of expression profile changes throughout disease progression for particular transcripts, comprehensive SNP profiling across disease stages, validation of potential biomarker candidates obtained from microarray data, and an in-depth exploration of the relevance of potential tumor suppressors or oncogenes across diverse cancer types.

We also offer Frozen Sections, Blocks, Tissue Protein Lysates, FFPE Sections, and More! View more Breast Cancer Tissue Products Here.

TissueScan Panels for Breast Cancer

Name	Description	Size	Cat #
TissueScan, Breast Cancer cDNA Array I	48 samples covering 7-normal, 10- Stage I, 13-IIA, 7-IIB, 8-IIIA, 3-IIIC.	2 panels	[BCRT101]
	TissueScan Breast Cancer Tissue qPCR Panel I (5) containing five identical sets of 48 tissues covering four disease stages and normal tissues.	5 panels	[BCRT301]
	TissueScan Breast Cancer Tissue qPCR Panel I (10) containing ten identical sets of 48 tissues covering four disease stages and normal tissues.	10 panels	[BCRT501]
TissueScan, Breast Cancer cDNA Array II	48 samples covering 5-normal, 11-Stage I, 8-IIA, 6-IIB, 8-IIIA, 2-IIIB, 4-IIIC, 4-IV.	2 panels	[BCRT102]
	TissueScan Breast Cancer Tissue qPCR Panel II (5) containing five identical sets of 48 tissues covering four disease stages and normal tissues.	5 panels	[BCRT302]
	TissueScan Breast Cancer Tissue qPCR Panel II (10) containing ten identical sets of 48 tissues covering four disease stage and normal tissues.	10 panels	[BCRT502]
TissueScan, Breast Cancer cDNA Array III	48 samples covering 12-Stage I, 6-IIA, 10-IIB, 7-IIIA, 3-IIIB, 5-IIIC, 5-IV.	2 panels	[BCRT103]
	TissueScan Breast Cancer Tissue qPCR Panel III (5) containing five identical sets of 48 tissues covering four disease stage tissues.	5 panels	[BCRT303]
	TissueScan Breast Cancer Tissue qPCR Panel III (10) containing ten identical sets of 48 tissues covering four disease stage tissues.	10 panels	[BCRT503]
miR-22	UP	TET1-3	EMT, stemness
TissueScan, Breast Cancer cDNA Array IV	48 samples covering 4-normal, 2-Stage I, 15-IIA, 9-IIB, 7-IIIA, 4-IIIB, 6-IIIC, 1-IV.	2 panels	[BCRT104]
	TissueScan Breast Cancer Tissue qPCR Panel IV (5) containing five identical sets of 48 tissues covering four disease stage tissues.	5 panels	[BCRT304]
	TissueScan Breast Cancer Tissue qPCR Panel IV (10) containing ten identical sets of 48 tissues covering four disease stage tissues.	10 panels	[BCRT504]

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