Stk11 (NM_001301854) Mouse Untagged Clone

CAT#: MC226958

Stk11 (untagged) - Mouse serine/threonine kinase 11 (Stk11), transcript variant 3

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Stk11
• Synonyms: AA408040; Lkb1; Par-4; R75140
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC226958 representing NM_001301854
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTATATGGTGATGGAGTACTGCGTATGTGGCATGCAGGAGATGCTGGACAGTGTGCCGGAGAAGCGCT
  TCCCTGTGTGCCAAGCTCATGGGTACTTCCGCCAGCTGATTGACGGCCTGGAATACCTACACAGCCAGGG
  CATTGTTCACAAGGACATCAAGCCGGGCAACCTGCTACTCACCACCAATGGCACACTCAAGATCTCCGAC
  CTCGGTGTTGCCGAGGCCCTGCACCCTTTCGCTGTGGATGACACCTGCCGGACAAGCCAGGGCTCCCCGG
  CCTTCCAGCCTCCTGAGATTGCCAATGGACTGGACACCTTTTCAGGTTTCAAGGTGGACATCTGGTCAGC
  TGGGGTCACACTTTACAACATCACCACGGGCCTGTACCCATTTGAGGGGGACAATATCTACAAGCTCTTT
  GAGAACATTGGGAGAGGAGACTTCACCATCCCTTGTGACTGCGGCCCACCACTCTCTGACCTACTCCGAG
  GGATGTTGGAGTATGAGCCGGCCAAGAGGTTCTCCATCCGACAGATTAGGCAGCACAGCTGGTTCCGGAA
  GAAACACCCTCTGGCTGAGGCGCTCGTACCTATCCCACCAAGCCCAGACACTAAGGACCGCTGGCGCAGT
  ATGACTGTAGTGCCCTACCTGGAGGACCTGCATGGCCGTGCGGAGGAGGAGGAGGAGGAAGACTTGTTTG
  ACATTGAGGACGGCATTATCTACACCCAGGACTTCACAGTGCCTGGACAGGTCCTGGAAGAGGAAGTGGG
  TCAGAATGGACAGAGCCACAGTTTGCCCAAGGCTGTTTGTGTGAATGGCACAGAGCCCCAGCTCAGCAGC
  AAGGTGAAGCCAGAAGGCCGACCTGGCACCGCCAACCCTGCGCGCAAGGTGTGCTCCAGCAACAAGATCC
  GCCGGCTCTCGGCCTGCAAGCAGCAGTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001301854
• ORF Size: 939 bp
• Insert Size: 939
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001301854.1, NP_001288783.1
• RefSeq Size: 2378
• RefSeq ORF: 939
• Locus ID: 20869
• Gene Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
  Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform L. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.