Cspg4 (NM_139001) Mouse Tagged ORF Clone

CAT#: MR226732

Cspg4 (Myc-DDK-tagged) - Mouse chondroitin sulfate proteoglycan 4 (Cspg4)

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Cspg4
• Synonyms: 4732461B14Rik; AN2; NG2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >MR226732 representing NM_139001.
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGCTTCTCGGCCCGGGACACCCGCTGTCAGCTCCAGCCCTGGCCTTGGCTCTTACCTTGGCCTTGTTG
  GTCAGATCTACAGCTCCTGCCTCCTTCTTCGGGGAGAACCACCTGGAGGTGCCCGTGCCCTCAGCTCTG
  ACCAGAGTAGACCTGCTGCTCCAGTTCTCCACATCCCAGCCCGAAGCCCTGCTCCTCTTGGCAGCAGGC
  CAAGATGACCATCTCTTGCTCCAGCTCCACTCAGGATGCCTCCAGGTCAGACTTGCCCTGGGACAGAAG
  GAGCTAAAGCTGCAGACGCCAGCAGACACCGTGCTGAGTGACTCTGCCCCCCACACTGTAGTGCTCACT
  GTCTCCGACAGCTGGGCTGTGCTGTCTGTTGACGGAGTGTTGAACACCTCTGCTCCCATCCCAAGAGCA
  TCCCACCTCAAGGCCACCTACGGGCTCTTCGTGGGCTCCTCTGGAAGCCTTGACCTGCCTTACCTGAAG
  GGAATCAGCCGACCCCTAAGGGGCTGCCTCCACTCAGCCATTCTCAATGGCCGCAACCTCCTCCGTCCG
  CTGACCTCCGATGTTCATGAAGGTTGTGCTGAAGAATTCTCTGCTGGTGATGAAGTGGGCCTGGGCTTC
  TCTGGGCCCCACTCACTGGCTGCCTTCCCTGCCTGGAGCACTCGGGAGGAAGGCACCCTGGAGTTTACG
  CTCACCACTCGGAGTCAGCAAGCACCCCTGGCCTTCCAAGCAGGGGACAAGCGTGGCAACTTTATCTAC
  GTGGACATATTTGAGGGCCACTTGCGGGCTGTGGTTGAGAAAGGCCAAGGTACCATGCTACTCCGCAAC
  AGCGTGCCTGTGGCTGATGGGCAGCCCCACGAGGTCAGCGTACACATAGATGTTCACCGGCTGGAAATC
  TCTGTAGACCAATACCCTACGCGTACTTTCAACCGTGGGGTCCTCAGCTACCTGGAGCCACGTGGCAGT
  CTCCTCCTTGGGGGTCTGGACACAGAAGCCTCTCGCCACCTCCAAGAGCACCGTCTGGGCCTGGCACCG
  GGGGCTGCCAATATCTCCCTGGTAGGCTGCATAGAAGATTTCAGTGTTAATGGCAGGAGGCAGGGCCTC
  CGGGATGCCTGGCTGACCCGTGACATGTCAGCAGGATGCAGGCCTGAGGAGGATGAATATGAAGAAGAG
  GTCTATGGCCCATATGAAACTTTCTCCACCCTGGCACCAGAAGCTTGGCCAGCCATGGAACTGCCAGAG
  CCATGTATTCCTGAGCCGGGACTGCCTGCTGTCTTTGCAAACTTCACCCAGCTGCTTACCATCAGCCCC
  CTGGTGGTGGCCGAGGGTGGCACGGCCTGGCTTGAGTGGCGGCACGTGCAGCCCACCCTGGACCTGACA
  GAGGCAGAGCTGCGCAAGTCCCAGGTGCTGTTCAGCGTGAGCCAGAGTGCACGACATGGTGACCTGGAG
  CTAGACATCCTGGGAGCCCAAACCCGGAAAATGTTTACCCTGTTGGACGTGGTGAACCGTAAGGCCCGC
  TTTGTTCACGATGGCTCTGAAGACACCTCTGACCAGCTGATGCTGGAGGTGTCTGTGACTGCTCGGGCA
  CCTGTGCCCTCCTGCCTGCGGAGGGGCCAAATTTACATCCTGCCCATCCAGGTCAATCCTGTCAACGAT
  CCACCTCGCATCATCTTCCCCCACGGCAGCCTCATGGTGATCCTGGAACACACACAGAAGCCTCTGGGA
  CCGGAGATTTTCCAGGCCTACGACCCGGACTCTGCCTGTGAGGGTCTCACCTTCCAGCTCCTTGGCGTC
  TCCTCTGGTGTCCCTGTGGAACACCGAGACCAGCCAGGAGAGCCAGCAACTGAGTTTTCCTGTCGGGAA
  CTGGAGGTGGGCGACATAGTCTATGTCCACCGTGGTGGGCCTGCACAGGACCTAACATTCCGGGTCAGT
  GATGGGATGCAGGCCAGTGCTCCAGCGACACTGAAGGTAGTGGCCGTCCGGCCAGCCATACAGATCCTC
  CACAACACAGGGCTGCACCTGGCCCAGGGCTCTGCCGCAGCCATCTTGCCTGCCAACCTGTCAGTAGAA
  ACGAACGCGGTGGGACAGGATGTGAGCGTGCTGTTCCGAGTCACTGGTACCTTGCAATTCGGGGAGCTG
  CAGAAGCAGGGGGCCGGAGGGGTCGAGGGCACCGAGTGGTGGGACACACTGGCCTTCCACCAGCGCGAT
  GTGGAGCAAGGCCGAGTGAGGTACCTGAGCACTGACCCACAGCACCACACCCAAGACACAGTGGAGGAC
  CTGATCTTAGAGGTGCAGGTGGGCCAGGAGACACTGAGCAATCTGTCTTTCCCAGTGACCATCCAGAGG
  GCCACAGTATGGATGCTGAGGCTTGAACCTCTGCATACACAGAACCCTCATCAGGAGACCCTCACCCCA
  GCCCACCTAGAGGCATCCCTGGAGGAAGAGGAGGAAGAGGGAAGCCCACAACCTCATACCTTCCACTAT
  GAGTTGGTTCAGGCCCCCAGAAGAGGCAACCTCCTGCTTCAGGGTACAAGGCTGTCAGACGGCGAGAGC
  TTCAGCCAGAGTGACCTGCAGGCCGGTCGGGTGACCTACAGGGCCACAATGCGGACCTCTGAGGCAGCC
  GATGACTCCTTCCGTTTCCGGGTCACATCCCCACCCCATTTCTCCCCGCTCTACACATTCCCCATCCAC
  ATTGGTGGTGACCCAAATGCTCCCGTCCTCACTAACGTCCTTCTCATGGTCCCCGAGGGAGGGGAGGGC
  GTGCTGTCTGCCGACCACCTCTTCGTCAAGAGTCTCAACAGCGCCAGCTATCTCTATGAGGTGATGGAG
  CAGCCTCACCATGGCAAGTTGGCTTGGAGGGACCCAAAGGGGAAGTCCACCCCAGTGACATCCTTCACT
  AATGAGGACCTACTTCATGGCCGACTGGTCTACCAGCACGATGACTCTGAGACCATAGAGGATGATATC
  CCGTTTGTGGCCACACGCCAGGGAGAGGGCAGTGGTGACATGGCCTGGGAGGAGGTGCGTGGTGTCTTC
  CGAGTGGCCATCCAGCCTGTGAATGACCACGCCCCTGTGCAGACCATTAGCCGTGTCTTCCACGTGGCC
  CGGGGTGGACAGCGACTGCTGACTACAGATGATGTAGCCTTCAGCGATGCTGATTCAGGGTTCAGTGAT
  GCGCAACTGGTGCTGACCCGCAAGGACCTCCTCTTTGGCAGCATTGTGGCTATGGAGGAGCCCACGAGG
  CCCATCTACCGGTTCACCCAAGAGGATCTCAGGAAGAAGCAAGTCCTGTTTGTGCACTCGGGGGCCGAC
  CACGGCTGGCTCCAGCTGCAGGTGTCTGATGGGCAGCACCAGGCTACTGCCATGCTGGAGGTCCAAGCC
  TCAGAACCCTATCTTCACGTAGCCAATAGTTCTAGTCTCGTGGTTCCTCAAGGAGGCCAGGGCACCATT
  GACACTGCTGTGCTCCAGCTGGACACCAACCTGGACATACGAAGTGGAAATGAGGTCCACTACCATGTA
  ACCGCTGGTCCTCAGTGGGGGCAGCTGCTCCGGGATGGCCAGTCAGTCACCTCCTTCTCCCAACGGGAC
  TTGCTCGATGGGGCCATCCTCTACAGCCACAATGGCAGCCTCAGCCCCCAAGACACCCTGGCGTTTTCT
  GTGGCAGCAGGGCCAGTACACACTAACACCTTCCTACAAGTGACCATTGCCCTCGAGGGTCCCCTGGCC
  CCACTGCAACTGGTGCAGCACAAAAAGATCTACGTCTTCCAGGGGGAAGCGGCTGAGATCAGAAGGGAC
  CAGCTAGAGGTGGTCCAGGAGGCAGTGCTGCCTGCCGACATCATGTTCTCGTTGAGAAGCCCCCCGAAC
  GCCGGCTACCTGGTGATGGTGTCCCACGGCGCTTCAGCAGAGGAGCCGCCCAGCCTGGACCCTGTGCAG
  AGCTTCTCCCAGGAGGCAGTGAATTCAGGCCGGGTTCTCTACCTGCACTCTCGCCCTGGAGCCTGGAGT
  GATTCCTTCTCCCTGGATGTGGCCTCGGGCCTGGGTGATCCTCTTGAAGGCATCTCTGTGGAGCTGGAG
  GTGCTGCCCACAGTCATCCCCCTGGATGTTCAAAACTTCAGCGTTCCCGAGGGCGGCACCCGGACGCTG
  GCCCCTCCTCTGGTCCAGATCACTGGGCCTTACTTCCCCACGCTGCCAGGCCTTGTCCTGCAGGTGCTA
  GAGCCACCGCAGCACGGGGCCCTGCAGAAGGAGGATCATTCTCAAGATGGGAGCCTCAGCACCTTCTCC
  TGGAGAGAGGTGGAAGAGCAGCTGATCCGCTACGTGCATGATGGAAGTGAGACACAGACAGACGCCTTT
  GTTCTGCTAGCTAATGCCTCAGAGATGGACCGCCAGAGCCAGCCCGTGGCCTTCACGATCACCATCCTT
  CCTGTTAATGACCAACCCCCTGTTCTCACCACAAACACAGGCCTGCAAATCTGGGAGGGGGCCATTGTG
  CCCATCCCTCCTGAGGCCCTCAGGGGAACAGACAATGATTCGGGCCCAGAAGACTTGGTCTACACCATC
  GAGCAGCCCAGCAACGGACGGATCGCCTTGAGGGTGGCACCAGACACCGAGGTCCACCGCTTCACACAG
  GCCCAGCTGGACAGTGGGCTTGTGCTGTTCTCACACAGAGGAGCCCTGGAAGGAGGCTTCCACTTCGAC
  CTCTCTGACGGCGCACACACTTCTCCTGGACATTTCTTCCGAGTGGTGGCCCAGAAGCAGGCACTCCTC
  TCCTTGGAGGGCACCCGGAAGTTGACCGTCTGTCCAGAGTCTGTGCAGCCGCTCAGCAGCCAGAGCCTG
  AGCGCCAGTTCCAGCACAGGCGCTGACCCTCGTCACCTGCTCTACCGGGTGGTAAGAGGCCCCCAGCTT
  GGCCGACTCCTCCATGCCCAGCAAGGAAGTGCAGAGGAGGTCTTGGTGAACTTCACCCAGGCTGAGGTA
  AATGCTGGGAATATTCTGTATGAGCACGAGATGTCCTCTGAGCCCTTCTGGGAAGCCCATGACACCATC
  GGTCTCCTACTGTCCTCACCACCTGCCAGGGATCTGGCTGCCACCCTGGCCGTGATGGTGTCTTTCGAT
  GCTGCCTGTCCCCAGCGCCCCAGCCGTCTCTGGAAGAACAAAGGTCTTTGGGTCCCCGAGGGCCAGCGG
  GCCAAGATCACTGTGGCTGCCCTTGATGCCGCCAACCTCCTAGCCAGTGTGCCAGCATCTCAGCGCAGT
  CGGCATGATGTACTCTTCCAGGTCACACAGTTCCCCACCCGAGGCCAGCTCCTGGTGTCTGAGGAGCCA
  CTCCATGCCAGGAGGCCCTACTTCCTGCAATCTGAGCTGGCCGCGGGACAGCTGGTGTACGCCCATGGT
  GGTGGGGGCACGCAGCAGGATGGCTTCCGCTTCCGTGCCCACCTCCAGGGACCGACGGGGACTTCTGTG
  GCAGGACCCCAGACCTCTGAGGCCTTTGTCATCACTGTGAGGGACGTGAATGAGCGGCCCCCTCAGCCA
  CAGGCCTCCATTCCTCTCCGTGTCACCAGGGGCTCACGAGCCCCTGTATCTCGAGCCCAGCTGAGTGTA
  GTCGACCCAGACTCAGCTCCAGGGGAAATTGAATATGAAGTACAGAGGGCACCCCACAATGGCTTCCTG
  AGCCTGGCTGGGGACAACACTGGACCTGTGACTCACTTCACACAGGCTGATGTGGATGCAGGGCGACTG
  GCCTTCGTGGCAAATGGGAGCAGTGTGGCCGGCGTCTTCCAGTTGAGCATGTCTGATGGAGCCAGCCCC
  CCCATACCCATGTCCCTGGCTGTGGATGTCTTGCCATCCACCATTGAGGTGCAGCTGCGTGCACCCCTG
  GAGGTGCCCCAAGCTCTAGGACGTACCTCACTGAGCCGGCAGCAGCTTCAGGTTATTTCCGATCGTGAG
  GAACCAGATGTAGCTTACCGCCTCACTCAGGGGCCCCTGTATGGGCAGCTACTAGTAGGGGGGCAGCCT
  GCCTCCGCCTTCAGCCAGCTGCAGGTAGACCAGGGGGACGTGGTCTTTGTCTTCACCAACTTCTCTTCC
  TCTCAGGATCACTTCAAAGTTGTAGCTCTGGCCAGGGGTGTGAACGCATCAGCCACCGTAAATGTCACA
  GTGCAGGCTCTGTTGCATGTGTGGGCTGGTGGGCCATGGCCTCAGGGTACCACCCTGCGCCTTGACCCC
  ACTGTGCTCGATGCCAGTGAGCTGGCCAACCGCACAGGCAGTATGCCCCACTTCCGGCTCCTGGCAGGA
  CCCCGCTATGGCCGTGTGGTCCGAGTGTCCCAAGGCCGAACAGAATCTAGGAGCAACCAACTTGTGGAA
  CATTTCACTCAGCGGGACCTGGAAGAGGGACAGCTGGGGCTAGAGGTGGGCAAGCCAGAGGGCAGGTCC
  ACTGGCCCAGCAGGTGACAGACTTACTCTGGAGCTGTGGGCAAAGGGTGTCCCACCTGCTGTGGCCTTG
  CTGGACTTTGCCACTGAGCCTTACCATGCGGCCAAATCCTACAGTGTGGCCCTACTCAGTGTCCCTGAG
  GCTGTTCGTACAGAAACAGAGAAACCAGGAAGAAGCGTCCCCACTGGCCAGCCAGGCCAGGCAGCATCC
  AGCCCCGTGCCCACTGCGGCCAAAGGTGGTTTCCTGGGCTTCTTAGAGGCCAACATGTTCAGCATCATC
  ATTCCGGTGTGCCTGATCCTCCTGCTCCTGGCCCTTATCTTGCCTCTGCTCTTCTACCTCCGCAAACGC
  AACAAGACGGGCAAGCACGATGTCCAGGTGTTGACCGCCAAACCCCGCAATGGCCTAGCCGGTGACACA
  GAGACCTTTCGAAAGGTAGAGCCAGGCCAAGCTATTCCACTCATAACTGTGCCTGGCCAGGGGCCCCCA
  CCAGGAGGCCAGCCTGACCCAGAACTATTGCAGTTTTGCCGGACACCCAATCCTGCCCTCAGGAATGGC
  CAGTACTGGGTG
  AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGAT
  ATCCTGGATTACAAGGATGACGACGATAAGGTTTAA
  
  Protein Sequence

  >Peptide sequence encoded by MR226732
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  MLLGPGHPLSAPALALALTLALLVRSTAPASFFGENHLEVPVPSALTRVDLLLQFSTSQPEALLLLAAG
  QDDHLLLQLHSGCLQVRLALGQKELKLQTPADTVLSDSAPHTVVLTVSDSWAVLSVDGVLNTSAPIPRA
  SHLKATYGLFVGSSGSLDLPYLKGISRPLRGCLHSAILNGRNLLRPLTSDVHEGCAEEFSAGDEVGLGF
  SGPHSLAAFPAWSTREEGTLEFTLTTRSQQAPLAFQAGDKRGNFIYVDIFEGHLRAVVEKGQGTMLLRN
  SVPVADGQPHEVSVHIDVHRLEISVDQYPTRTFNRGVLSYLEPRGSLLLGGLDTEASRHLQEHRLGLAP
  GAANISLVGCIEDFSVNGRRQGLRDAWLTRDMSAGCRPEEDEYEEEVYGPYETFSTLAPEAWPAMELPE
  PCIPEPGLPAVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLTEAELRKSQVLFSVSQSARHGDLE
  LDILGAQTRKMFTLLDVVNRKARFVHDGSEDTSDQLMLEVSVTARAPVPSCLRRGQIYILPIQVNPVND
  PPRIIFPHGSLMVILEHTQKPLGPEIFQAYDPDSACEGLTFQLLGVSSGVPVEHRDQPGEPATEFSCRE
  LEVGDIVYVHRGGPAQDLTFRVSDGMQASAPATLKVVAVRPAIQILHNTGLHLAQGSAAAILPANLSVE
  TNAVGQDVSVLFRVTGTLQFGELQKQGAGGVEGTEWWDTLAFHQRDVEQGRVRYLSTDPQHHTQDTVED
  LILEVQVGQETLSNLSFPVTIQRATVWMLRLEPLHTQNPHQETLTPAHLEASLEEEEEEGSPQPHTFHY
  ELVQAPRRGNLLLQGTRLSDGESFSQSDLQAGRVTYRATMRTSEAADDSFRFRVTSPPHFSPLYTFPIH
  IGGDPNAPVLTNVLLMVPEGGEGVLSADHLFVKSLNSASYLYEVMEQPHHGKLAWRDPKGKSTPVTSFT
  NEDLLHGRLVYQHDDSETIEDDIPFVATRQGEGSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRVFHVA
  RGGQRLLTTDDVAFSDADSGFSDAQLVLTRKDLLFGSIVAMEEPTRPIYRFTQEDLRKKQVLFVHSGAD
  HGWLQLQVSDGQHQATAMLEVQASEPYLHVANSSSLVVPQGGQGTIDTAVLQLDTNLDIRSGNEVHYHV
  TAGPQWGQLLRDGQSVTSFSQRDLLDGAILYSHNGSLSPQDTLAFSVAAGPVHTNTFLQVTIALEGPLA
  PLQLVQHKKIYVFQGEAAEIRRDQLEVVQEAVLPADIMFSLRSPPNAGYLVMVSHGASAEEPPSLDPVQ
  SFSQEAVNSGRVLYLHSRPGAWSDSFSLDVASGLGDPLEGISVELEVLPTVIPLDVQNFSVPEGGTRTL
  APPLVQITGPYFPTLPGLVLQVLEPPQHGALQKEDHSQDGSLSTFSWREVEEQLIRYVHDGSETQTDAF
  VLLANASEMDRQSQPVAFTITILPVNDQPPVLTTNTGLQIWEGAIVPIPPEALRGTDNDSGPEDLVYTI
  EQPSNGRIALRVAPDTEVHRFTQAQLDSGLVLFSHRGALEGGFHFDLSDGAHTSPGHFFRVVAQKQALL
  SLEGTRKLTVCPESVQPLSSQSLSASSSTGADPRHLLYRVVRGPQLGRLLHAQQGSAEEVLVNFTQAEV
  NAGNILYEHEMSSEPFWEAHDTIGLLLSSPPARDLAATLAVMVSFDAACPQRPSRLWKNKGLWVPEGQR
  AKITVAALDAANLLASVPASQRSRHDVLFQVTQFPTRGQLLVSEEPLHARRPYFLQSELAAGQLVYAHG
  GGGTQQDGFRFRAHLQGPTGTSVAGPQTSEAFVITVRDVNERPPQPQASIPLRVTRGSRAPVSRAQLSV
  VDPDSAPGEIEYEVQRAPHNGFLSLAGDNTGPVTHFTQADVDAGRLAFVANGSSVAGVFQLSMSDGASP
  PIPMSLAVDVLPSTIEVQLRAPLEVPQALGRTSLSRQQLQVISDREEPDVAYRLTQGPLYGQLLVGGQP
  ASAFSQLQVDQGDVVFVFTNFSSSQDHFKVVALARGVNASATVNVTVQALLHVWAGGPWPQGTTLRLDP
  TVLDASELANRTGSMPHFRLLAGPRYGRVVRVSQGRTESRSNQLVEHFTQRDLEEGQLGLEVGKPEGRS
  TGPAGDRLTLELWAKGVPPAVALLDFATEPYHAAKSYSVALLSVPEAVRTETEKPGRSVPTGQPGQAAS
  SPVPTAAKGGFLGFLEANMFSIIIPVCLILLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDT
  ETFRKVEPGQAIPLITVPGQGPPPGGQPDPELLQFCRTPNPALRNGQYWV
  SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
  
• Restriction Sites: SgfI-RsrII Cloning Scheme for this gene Plasmid Map
• ACCN: NM_139001
• ORF Size: 6981 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_139001.2, NP_620570.2
• RefSeq Size: 8050 bp
• RefSeq ORF: 6984 bp
• Locus ID: 121021
• UniProt ID: Q8VHY0
• Cytogenetics: 9 B
• MW: 252.3 kDa
• Gene Summary: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.[UniProtKB/Swiss-Prot Function]