Slc11a1 (NM_013612) Mouse Tagged ORF Clone

CAT#: MR227222L3

Lenti ORF clone of Slc11a1 (Myc-DDK-tagged) - Mouse solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Slc11a1)

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Slc11a1
• Synonyms: Bcg; Ity; ity; Ity1; Lsh; Nramp; Nramp1
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR227222).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_013612
• ORF Size: 1647 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_013612.2, NP_038640.2
• RefSeq Size: 2304
• RefSeq ORF: 1647
• Locus ID: 18173
• Gene Summary: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. [UniProtKB/Swiss-Prot Function]