Arntl (NM_001243048) Mouse Tagged ORF Clone

CAT#: MR230678

Arntl (myc-DDK-tagged) - Mouse aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 2

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Arntl
• Synonyms: Arnt3; bHLHe5; Bmal1; BMAL1b; bmal1b'; MOP3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >MR230678 representing NM_001243048
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGGACCAGAGAATGGACATTTCCTCAACCATCAGCGACTTCATGTCTCCGGGCCCCACCGACCTAC
  TCTCCGGTTCCCTGGGCACCAGTGGTGTGGACTGCAATCGCAAGAGGAAAGGCAGTGCCACTGACTACCA
  GTTAGAATATGCAGAACACCAAGGAAGGATCAAGAATGCAAGGGAGGCCCACAGTCAGATTGAAAAGAGG
  CGTCGGGACAAAATGAACAGTTTCATTGATGAATTGGCTTCTTTGGTACCAACATGCAATGCAATGTCCA
  GGAAGTTAGATAAACTCACCGTGCTAAGGATGGCTGTTCAGCACATGAAAACTTTGAGAGGTGCCACCAA
  CCCATACACAGAAGCAAACTACAAGCCAACATTTCTATCAGATGACGAACTGAAACACCTAATTCTCAGG
  GCAGCAGATGGATTTTTGTTTGTCGTAGGATGTGACCGAGGGAAGATCCTCTTTGTCTCCGAGTCTGTCT
  TCAAGATCCTCAATTATAGCCAGAATGACCTTATTGGCCAGAGCTTGTTTGACTACCTGCATCCAAAAGA
  TATTGCCAAAGTTAAGGAACAGCTATCTTCCTCGGACACTGCGCCCCGGGAGCGACTCATTGATGCCAAG
  ACTGGACTTCCGGTTAAAACGGATATAACCCCTGGGCCCTCCCGGCTATGCTCTGGAGCCCGCCGCTCTT
  TCTTCTGTAGAATGAAGTGCAACAGGCCTTCAGTAAAGGTGGAAGATAAGGACTTCGCCTCTACCTGTTC
  AAAGAAAAAAGCAGATCGAAAAAGCTTCTGCACAATCCACAGCACAGGCTATTTGAAAAGCTGGCCACCC
  ACGAAGATGGGGCTGGACGAAGACAATGAGCCAGACAACGAGGGCTGCAACCTCAGCTGCCTCGTTGCAA
  TCGGGCGCCTGCACTCGCACATGGTTCCACAACCAGCGAACGGGGAAATACGGGTGAAATCTATGGAGTA
  CGTTTCTCGACACGCAATAGATGGGAAATTTGTTTTTGTAGATCAGAGGGCGACAGCTATTTTGGCGTAT
  CTACCACAGGAACTTCTAGGTACATCATGTTATGAGTATTTTCATCAAGACGACATAGGACACCTCGCAG
  AATGTCACAGGCAAGTTTTACAGACAAGAGAAAAGATCACAACTAATTGCTATAAGTTTAAGATCAAAGA
  TGGTTCTTTTATCACGCTACGAAGTCGATGGTTCAGTTTCATGAACCCGTGGACCAAGGAAGTTGAATAC
  ATTGTCTCAACCAACACTGTTGTTTTAGCCAATGTCCTGGAAGGCGGGGACCCAACCTTCCCGCAGCTAA
  CAGCACCCCCCCACAGCATGGACAGCATGCTGCCCTCTGGAGAAGGTGGCCCAAAGAGGACTCATCCCAC
  TGTCCCAGGCATTCCAGGGGGAACCAGAGCCGGAGCAGGAAAAATAGGTCGAATGATCGCGGAGGAAATC
  ATGGAAATCCACAGGATAAGAGGGTCATCGCCTTCCAGCTGTGGCTCCAGCCCGCTGAACATCACAAGTA
  CGCCTCCCCCTGATGCCTCTTCTCCAGGAGGCAAGAAGATTCTAAATGGAGGGACTCCAGACATTCCTTC
  CACTGGACTATTACCAGGGCAGGCTCAGGAGACCCCAGGGTATCCCTATTCTGATAGTTCTTCTATTCTT
  GGTGAGAACCCCCACATAGGCATCGATATGATAGATAACGACCAAGGATCAAGTAGTCCCAGTAACGATG
  AGGCAGCAATGGCTGTCATCATGAGCCTCTTGGAAGCAGATGCGGGGCTGGGTGGCCCCGTTGACTTTAG
  TGACTTGCCATGGCCGCTG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >MR230678 representing NM_001243048
  Red=Cloning site Green=Tags(s)
  
  MADQRMDISSTISDFMSPGPTDLLSGSLGTSGVDCNRKRKGSATDYQLEYAEHQGRIKNAREAHSQIEKR
  RRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILR
  AADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAK
  TGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFASTCSKKKADRKSFCTIHSTGYLKSWPP
  TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHMVPQPANGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY
  LPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEY
  IVSTNTVVLANVLEGGDPTFPQLTAPPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEI
  MEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSTGLLPGQAQETPGYPYSDSSSIL
  GENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001243048
• ORF Size: 1839 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001243048.1, NP_001229977.1
• RefSeq Size: 2628
• RefSeq ORF: 1842
• Locus ID: 11865
• MW: 67.7 kDa
• Gene Summary: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]