Constitutive androstane receptor (NR1I3) (NM_001077480) Human Tagged ORF Clone
CAT#: RC210209L3
- LentiORF®
Lenti-ORF clone of NR1I3 (Myc-DDK-tagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2
"NM_001077480" in other vectors (4)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | NR1I3 |
Synonyms | CAR; CAR1; MB67 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC210209).
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Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_001077480 |
ORF Size | 1056 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001077480.2, NP_001070948.1 |
RefSeq Size | 1399 |
RefSeq ORF | 1059 |
Locus ID | 9970 |
Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
MW | 39.9 kDa |
Gene Summary | This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
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SC315539 | NR1I3 (untagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2 |
USD 760.00 |
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RC210209 | NR1I3 (Myc-DDK-tagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2 |
USD 420.00 |
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RG210209 | NR1I3 (GFP-tagged) - Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2 |
USD 460.00 |
|
RC210209L4 | Lenti-ORF clone of NR1I3 (mGFP-tagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2 |
USD 620.00 |
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