TXNRD1 (NM_001093771) Human Tagged ORF Clone
CAT#: RC211559L3
- LentiORF®
Lenti-ORF clone of TXNRD1 (Myc-DDK-tagged)-Human thioredoxin reductase 1 (TXNRD1), transcript variant 5, (Note, selenocystein protein, internal stop codon, see summary)
"NM_001093771" in other vectors (4)
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | TXNRD1 |
Synonyms | GRIM-12; TR; TR1; TRXR1; TXNR |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC211559).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_001093771 |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info The expression of this clone is not guaranteed due to the nature of selenoproteins. |
OTI Annotation | This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001093771.1, NP_001087240.1 |
RefSeq Size | 3859 bp |
RefSeq ORF | 1950 bp |
Locus ID | 7296 |
Cytogenetics | 12q23.3 |
Protein Families | Druggable Genome |
Protein Pathways | Pyrimidine metabolism |
Gene Summary | 'The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]' |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC316250 | TXNRD1 (untagged)-Human thioredoxin reductase 1 (TXNRD1), transcript variant 5 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) |
USD 1,100.00 |
|
RC211559 | TXNRD1 (Myc-DDK-tagged)-Human thioredoxin reductase 1 (TXNRD1), transcript variant 5, (Note, selenocysteine protein, internal stop codon, see reference data summary) |
USD 480.00 |
|
RG211559 | TXNRD1 (GFP-tagged) - Human thioredoxin reductase 1 (TXNRD1), transcript variant 5, (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) |
USD 530.00 |
|
RC211559L4 | Lenti-ORF clone of TXNRD1 (mGFP-tagged)-Human thioredoxin reductase 1 (TXNRD1), transcript variant 5, (Note, selenocystein protein, internal stop codon, see summary) |
USD 680.00 |
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