APPBP1 (NAE1) (NM_003905) Human Tagged ORF Clone

CAT#: RC213781L2

Lenti ORF clone of Human NEDD8 activating enzyme E1 subunit 1 (NAE1), transcript variant 1, mGFP tagged

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: NAE1
• Synonyms: A-116A10.1; APPBP1; HPP1; ula-1
• Vector: pLenti-C-mGFP
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC213781).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_003905
• ORF Size: 1602 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003905.3, NP_003896.1
• RefSeq Size: 1820
• RefSeq ORF: 1605
• Locus ID: 8883
• Domains: ThiF
• Protein Pathways: Alzheimer's disease
• MW: 60.1 kDa
• Gene Summary: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]