DPYD (NM_000110) Human Tagged ORF Clone
CAT#: RC216374L3
- LentiORF®
Lenti ORF clone of Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, Myc-DDK-tagged
"NM_000110" in other vectors (4)
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | DPYD |
Synonyms | DHP; DHPDHASE; DPD |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC216374).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_000110 |
ORF Size | 3075 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_000110.3, NP_000101.2 |
RefSeq Size | 4451 bp |
RefSeq ORF | 3078 bp |
Locus ID | 1806 |
Cytogenetics | 1p21.3 |
Domains | DHOdehase, fer4 |
Protein Families | Druggable Genome |
Protein Pathways | beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism |
MW | 111.4 kDa |
Gene Summary | 'The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]' |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC316297 | DPYD (untagged)-Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1 |
USD 1,100.00 |
|
RC216374 | DPYD (Myc-DDK-tagged)-Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1 |
USD 600.00 |
|
RG216374 | DPYD (GFP-tagged) - Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1 |
USD 660.00 |
|
RC216374L4 | Lenti ORF clone of Human dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mGFP tagged |
USD 800.00 |
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