HCN4 (NM_005477) Human Tagged ORF Clone

CAT#: RC216770L4

Lenti-ORF clone of HCN4 (mGFP-tagged)-Human hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: HCN4
• Synonyms: SSS2
• Vector: pLenti-C-mGFP-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC216770).
• Restriction Sites: SgfI-XhoI Cloning Scheme for this gene
• ACCN: NM_005477
• ORF Size: 3609 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_005477.1, NP_005468.1
• RefSeq Size: 5065
• RefSeq ORF: 3612
• Locus ID: 10021
• Domains: cNMP, ion_trans
• Protein Families: Druggable Genome, Ion Channels: Cyclic nucleotide gated, Transmembrane
• MW: 128.9 kDa
• Gene Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]