PCDHGA11 (NM_018914) Human Tagged ORF Clone

CAT#: RC217347

PCDHGA11 (Myc-DDK-tagged)-Human protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: PCDHGA11
• Synonyms: PCDH-GAMMA-A11
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC217347 representing NM_018914
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGAATCGGCTACAGCGCGGGGACCGCAGTCGGCTGCTGCTGCTGCTGTGCATTTTCCTGGGGACGC
  TGCGGGGGTTCCGGGCCAGGCAGATCCGATATTCGGTGCCAGAAGAGACCGAAAAGGGCTCCTTCGTGGG
  CAATATCTCCAAGGACCTGGGGCTGGAGCCCCGGGAGCTGGCGAAGCGCGGAGTCCGCATCGTCTCCAGA
  GGGAAGACACAGCTTTTCGCTGTGAATCCGCGAAGCGGCAGCTTGATCACGGCAGGCAGGATAGACCGGG
  AGGAGCTCTGTGAGACGGTGTCCTCCTGTTTTTTAAATATGGAACTTCTCGTGGAAGACACCTTGAAGAT
  TTACGGAGTGGAGGTGGAAATAATAGATATTAATGATAACGCCCCCAGCTTCCAGGAGGACGAAGTGGAG
  ATAAAAGTCAGTGAGCACGCAATTCCTGGGGCGCGATTTGCTCTTCCTAATGCTAGGGATCCAGATGTGG
  GCGTGAACTCCCTCCAGAGCTACCAGCTCAGCCCTAATAATTACTTTTCCTTGCAACTGCGGGGCAGAAC
  GGATGGGGCCAAGAATCCAGAGCTAGTACTGGAGGGAAGCCTGGACCGAGAGAAAGAGGCTGCTCACCTG
  CTCCTCCTCACAGCTTTAGATGGAGGCGATCCCATCCGAAAGGGCGCAGTTCCCATTCGTGTGGTGGTCC
  TCGATGTAAATGATCACATCCCAATGTTTACACAGTCCGTATATCGCGTGAGTGTTCCAGAAAACATCAG
  CTCCGGAACTCGGGTGCTGATGGTTAATGCAACGGATCCAGACGAGGGAATCAACGGGGAAGTAATGTAT
  TCATTTCGGAACATGGAAAGCAAGGCTTCTGAAATATTCCAATTGGATTCACAAACTGGAGAAGTTCAAG
  TACGGGGGTCTCTGGATTTTGAAAAATATAGATTCTATGAGATGGAAATTCAAGGCCAAGATGGTGGAGG
  TCTCTTTACCACCACGACGATGTTGATCACTGTTGTGGATGTGAATGATAACGCTCCAGAAATAACTATC
  ACCTCTTCTATTAATTCAATTCTGGAAAACTCTCCTCCAGGTACAGTGATTGCTCTTCTAAATGTGCAAG
  ATCAAGATTCTGGAGAAAATGGTCAAGTCTCCTGTTTTATTCCTAACCACCTGCCTTTTAAATTAGAAAA
  GACTTATGGAAATTATTACAAATTGATAACAAGCAGAGTGCTGGACAGGGAGTTGGTCCAGAGCTACAAT
  ATAACGTTGACAGCCACAGACCAGGGAAGCCCGCCTTTGTCTGCAGAAACTCATGTCTGGCTGAATGTGG
  CAGATGACAACGATAACCCTCCCGTTTTTCCTCACTCCTCTTACTCTGCCTACATTCCCGAAAACAACCC
  CAGGGGTGCCTCCATCTTCTCAGTGACCGCCCTCGACCCGGACAGCAAACAGAATGCCCTGGTCACTTAC
  TCTCTGACGGATGACACTGTCCAGGGGGTGCCTCTGTCCTCCTATGTCTCTATTAACTCCAACACTGGTG
  TTCTCTATGCCCTACAATCCTTCGACTATGAGCAGTTTCGAGACTTAGAACTGAGAGTGATAGCACGTGA
  CAGCGGGGACCCGCCCCTCAGCAGCAACGTGTCGCTGAGCCTGTTCGTGCTGGACCAGAACGACAATGCG
  CCCGAGATCCTGTACCCTGCCCTCCCCACAGACGGCTCCACTGGCGTGGAGCTGGCGCCCCGCTCTGCGG
  AACCTGGCTACCTGGTGACCAAGGTGGTTGCGGTGGACAAAGATTCAGGCCAGAACGCCTGGCTGTCCTA
  TCGCCTGCTTAAGGCCAGCGAGCCGGGACTCTTCGCGGTGGGGGAGCACACGGGCGAGGTGCGTACAGCG
  CGGGCACTGCTGGACAGAGACGCGCTCAAGCAGAGCCTCGTGGTGGCCGTCCAGGACCACGGCCAGCCCC
  CTCTCTCGGCCACCGTCACGCTCACCGTGGCTGTGGCCGACAGCATCCCCGAAGTCCTGGCGGACCTCGG
  CAGCCTCGAGTCTCTGGCTAACTCTGAAACCTCAGACCTCTCGCTGTACTTGGTGGTGGCGGTGGCCGCA
  GTCTCCTGCATCTTCCTGGTCTTTGTCATCGTGCTGCTGGCACTCAGGCTGTGGCGCTGGCATAAGTCAC
  GCCTGCTGCAGGCTTCTGAAGGCGGGTTGGCAGGTATGCCCACGTCACATTTTGTAGGCGTGGACGGGGT
  ACAGGCTTTCCTGCAAACCTATTCCCACGAGGTCTCTCTCATTGCGGACTCGCAGAAGAGTCACCTGATT
  TTCCCCCAGCCCAACTATGGGGACACGCTCATCAGCCAGGAGAGCTGTGAGAAAAGCGAGCCACTCTTGA
  TAGCTGAAGACTCAGCTATCATTTTAGGCAAATGTGACCCGACAAGTAATCAGCAAGCCCCGCCCAACAC
  GGACTGGCGTTTCTCTCAGGCCCAGAGACCCGGCACCAGCGGCTCCCAAAATGGCGATGACACCGGCACC
  TGGCCCAACAACCAGTTTGACACAGAGATGCTGCAAGCCATGATCTTGGCGTCCGCCAGTGAAGCTGCTG
  ATGGGAGCTCCACCCTGGGAGGGGGTGCCGGCACCATGGGATTGAGCGCCCGCTACGGACCCCAGTTCAC
  CCTGCAGCACGTGCCCGACTACCGCCAGAATGTCTACATCCCAGGCAGCAATGCCACACTGACCAACGCA
  GCTGGCAAGCGGGATGGCAAGGCCCCAGCAGGTGGCAATGGCAACAAGAAGAAGTCGGGCAAGAAGGAGA
  AGAAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC217347 representing NM_018914
  Red=Cloning site Green=Tags(s)
  
  MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR
  GKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVE
  IKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHL
  LLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMY
  SFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITI
  TSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN
  ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTY
  SLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNA
  PEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTA
  RALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLESLANSETSDLSLYLVVAVAA
  VSCIFLVFVIVLLALRLWRWHKSRLLQASEGGLAGMPTSHFVGVDGVQAFLQTYSHEVSLIADSQKSHLI
  FPQPNYGDTLISQESCEKSEPLLIAEDSAIILGKCDPTSNQQAPPNTDWRFSQAQRPGTSGSQNGDDTGT
  WPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNA
  AGKRDGKAPAGGNGNKKKSGKKEKK
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_018914
• ORF Size: 2805 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_018914.1, NM_018914.2, NP_061737.1
• RefSeq Size: 4872
• RefSeq ORF: 2808
• Locus ID: 56105
• Domains: CA
• Protein Families: Transmembrane
• MW: 98.5 kDa
• Gene Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]