DENN (MADD) (NM_130476) Human Tagged ORF Clone

CAT#: RC219346L3

Lenti-ORF clone of MADD (Myc-DDK-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 8

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: MADD
• Synonyms: DENN; IG20; RAB3GEP
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219346).
• Restriction Sites: SgfI-RsrII Cloning Scheme for this gene
• ACCN: NM_130476
• ORF Size: 4761 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_130476.2, NP_569832.1, NP_569832.2
• RefSeq Size: 5875
• RefSeq ORF: 4764
• Locus ID: 8567
• Domains: DENN, dDENN, uDENN
• Protein Families: Druggable Genome
• MW: 176.9 kDa
• Gene Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]