NLRP3 (NM_004895) Human Tagged ORF Clone
CAT#: RC220952L2
- LentiORF®
Lenti ORF clone of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, mGFP tagged
"NM_004895" in other vectors (6)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | NLRP3 |
Synonyms | AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1 |
Vector | pLenti-C-mGFP |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC220952).
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Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_004895 |
ORF Size | 3108 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_004895.3, NP_004886.3 |
RefSeq Size | 4484 |
RefSeq ORF | 3111 |
Locus ID | 114548 |
Domains | LRR, LRR_RI, PAAD_DAPIN |
Protein Families | Druggable Genome |
Protein Pathways | NOD-like receptor signaling pathway |
MW | 118 kDa |
Gene Summary | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008] |
Documents
Product Manuals |
FAQs |
SDS |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC110747 | NLRP3 (untagged)-Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 |
USD 1,100.00 |
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RC220952 | NLRP3 (Myc-DDK-tagged)-Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 |
USD 600.00 |
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RG220952 | NLRP3 (GFP-tagged) - Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 |
USD 660.00 |
|
RC220952L1 | Lenti ORF clone of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, Myc-DDK-tagged |
USD 984.00 |
|
RC220952L3 | Lenti ORF clone of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, Myc-DDK-tagged |
USD 984.00 |
|
RC220952L4 | Lenti ORF clone of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, mGFP tagged |
USD 800.00 |
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