Neurexin 1 (NRXN1) (NM_001135659) Human Tagged ORF Clone
CAT#: RC226688
NRXN1 (Myc-DDK-tagged)-Human neurexin 1 (NRXN1), transcript variant alpha2
"NM_001135659" in other vectors (6)
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | NRXN1 |
Synonyms | Hs.22998; PTHSL2; SCZD17 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC226688 representing NM_001135659
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTCTGTGCCTCTCGCTGCTGCTCCTGGGCTGCT GGGCGGAGCTGGGCAGCGGGCTGGAGTTTCCGGGCGCCGAGGGCCAATGGACGCGCTTCCCCAAGTGGAA CGCCTGCTGCGAGAGCGAGATGAGCTTCCAGCTCAAGACTCGCAGCGCCCGCGGCCTCGTGCTCTACTTC GACGACGAGGGCTTCTGCGACTTCCTGGAGCTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT CCATCTTCTGCGCTGAGCCTGCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCTGGCACAGCGT GCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGGAGGCCAAGTGGGTGGAGGTC AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTTTCGTCGGGGGGCTGCCCCCGGAACTGCGCG CCGCGGCGCTCAAGCTCACCCTGGCCTCGGTGAGGGAGCGGGAGCCCTTCAAGGGGTGGATTCGTGACGT GAGGGTCAACTCCTCGCAGGTCCTGCCCGTGGACAGCGGCGAGGTGAAGCTGGACGATGAGCCGCCCAAC AGCGGCGGGGGAAGCCCGTGCGAGGCGGGCGAGGAGGGCGAGGGCGGGGTGTGCCTCAACGGAGGTGTGT GCTCCGTGGTGGACGACCAGGCCGTGTGCGACTGCTCGCGAACCGGCTTCCGCGGCAAGGACTGCAGCCA AGAAATAAAATTCGGTCTTCAGTGTGTTTTGCCGGTGCTGTTACATGACAATGACCAAGGAAAATACTGT TGTATAAATACAGCAAAGCCTCTAACAGAAAAAGACAACAATGTGGAAGGTCTGGCGCACCTGATGATGG GCGACCAAGGTAAAAGTAAAGGAAAAGAAGAATATATTGCCACGTTCAAAGGATCTGAATACTTCTGCTA CGACTTGTCTCAAAACCCCATTCAAAGCAGCAGTGATGAAATAACTCTGTCATTTAAAACCCTTCAGAGG AATGGACTGATGCTTCACACTGGGAAATCGGCTGATTATGTCAATCTTGCCCTGAAAAATGGAGCTGTCT CTCTGGTCATTAATTTGGGATCAGGGGCCTTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGA TAATGCCTGGCATGATGTGAAAGTCACCAGGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTA AACAAACTACATTGTTCGGTGACAATATCAGTGGATGGGATTCTTACCACAACGGGCTACACGCAAGAAG ATTATACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGTCCCAGCACAGCCGACCTTCCAGG GTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAGGTTGTATATAAAAATAATGATGTGAGGCTG GAATTATCTCGACTTGCCAAGCAAGGAGATCCTAAGATGAAGATCCATGGAGTGGTGGCATTTAAATGTG AGAATGTTGCAACTTTAGACCCAATCACCTTTGAAACCCCAGAGTCTTTCATCTCTTTGCCTAAATGGAA TGCAAAGAAAACTGGCTCCATATCATTTGATTTCCGTACAACAGAGCCAAATGGCCTCATCTTATTTAGC CATGGCAAGCCAAGACATCAGAAAGATGCCAAGCACCCACAGATGATAAAGGTGGACTTCTTTGCTATTG AGATGCTAGATGGCCACCTCTACCTCCTCCTGGACATGGGGTCAGGTACTATAAAAATAAAAGCCCTGTT GAAGAAAGTGAATGATGGAGAATGGTATCATGTGGACTTCCAGAGAGACGGACGGTCAGGTACCATTTCT GTCAACACGTTGCGTACTCCCTACACTGCTCCTGGTGAGAGTGAGATTCTGGACCTGGATGATGAGTTGT ACCTGGGGGGGCTGCCAGAAAATAAAGCTGGCCTTGTCTTCCCCACCGAGGTGTGGACTGCTCTGCTCAA CTATGGCTACGTGGGCTGCATCAGGGATTTGTTCATCGATGGCCAAAGCAAAGATATCCGGCAAATGGCT GAAGTTCAAAGTACTGCTGGAGTGAAGCCTTCCTGCTCAAAGGAAACAGCAAAACCGTGCCTTAGCAACC CTTGCAAAAACAATGGCATGTGCAGGGATGGGTGGAACAGATATGTCTGTGATTGTTCCGGAACAGGCTA TCTTGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGCTATGATGGGAGCATGTTTATGAAAATTCAG CTCCCCGTAGTCATGCATACGGAGGCTGAGGATGTTTCCTTACGGTTCCGATCCCAGCGTGCATATGGCA TTCTGATGGCAACCACTTCTAGAGACTCTGCTGACACCCTCCGCCTGGAGCTAGACGCAGGACGTGTGAA ACTGACGGTCAATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAGGTCCCGAGACTCTTTTTGCT GGCTATAACCTCAATGATAACGAGTGGCACACAGTGCGTGTAGTTCGGCGTGGAAAAAGTTTAAAGTTAA CAGTGGATGACCAACAGGCCATGACAGGTCAAATGGCAGGTGATCATACTAGGCTGGAGTTCCATAACAT AGAGACTGGCATCATCACAGAACGACGGTATCTTTCTTCTGTCCCCTCCAACTTCATTGGACACCTGCAG AGCTTGACATTTAATGGAATGGCATACATTGACCTGTGTAAAAATGGCGACATAGATTACTGTGAGCTTA ATGCCAGATTTGGCTTCAGGAACATCATAGCAGATCCTGTCACCTTCAAGACCAAATCGAGCTATGTTGC CTTAGCTACCTTGCAAGCCTACACTTCTATGCATCTTTTTTTCCAGTTCAAGACAACATCCCTAGATGGA TTAATTCTATATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATTAGTTAAAGGGTACTTACATT ACGTGTTTGATTTGGGAAATGGTGCTAACCTCATCAAAGGAAGCTCAAATAAACCTCTCAATGACAATCA GTGGCACAACGTGATGATATCAAGGGACACCAGCAACCTCCACACTGTAAAGATTGACACAAAAATCACA ACGCAAATCACCGCCGGAGCCAGGAACTTAGACCTCAAGAGTGACTTATATATAGGAGGAGTAGCTAAAG AAACATACAAATCCTTACCAAAACTTGTACATGCCAAAGAAGGCTTTCAAGGCTGCCTGGCATCAGTTGA TTTAAATGGACGGCTTCCGGACCTCATCTCCGATGCTCTTTTCTGCAACGGACAGATCGAGAGAGGATGT GAAGGGCCCAGCACAACCTGCCAAGAGGACTCATGTTCCAATCAAGGTGTGTGCTTGCAACAATGGGATG GCTTCAGCTGTGACTGTAGTATGACTTCCTTCAGTGGACCACTCTGCAATGACCCTGGGACGACATATAT CTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCTCCTAATGACCGACCCAGTACACGAGCAGAC AGACTGGCCATAGGTTTTAGCACTGTTCAGAAAGAAGCCGTATTGGTGCGAGTGGACAGTTCTTCAGGCT TGGGTGACTACCTAGAACTGCATATACACCAGGGAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGA CATCGCCATTGAAGAATCCAATGCAATCATTAATGATGGGAAATACCATGTAGTTCGTTTCACGAGGAGT GGTGGCAATGCCACGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTACCCTGCAGGAAACAATGATA ACGAGCGCCTGGCGATTGCTAGACAGCGAATTCCATATCGACTTGGTCGAGTAGTTGATGAATGGCTACT CGACAAAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGC CAGCCCTTCCAGGGCCAGCTCTCTGGGCTGTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAA ACGATGCCAACATCGCCATAGTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGACAACTGA GTCAACAGCCACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTACCACGACCCTGGCTACT AGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTAGCCAGACCACAGATGACATCCTTGTGG CCTCAGCAGAGTGTCCCAGCGATGATGAGGACATTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAA CCCAACCCGAGCAGGCGGCAGAGAGCCGTATCCAGGCTCAGCAGAAGTGATCCGGGAGTCCAGCAGCACC ACGGGTATGGTCGTTGGGATAGTAGCCGCTGCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACA AGTACAGAAACCGGGATGAAGGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACTCAGCACA GTCCAATGGGGCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCAACAAAAATAAGAAAAAC AAGGATAAAGAGTATTATGTC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC226688 representing NM_001135659
Red=Cloning site Green=Tags(s) MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYF DDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEV KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPN SGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYC CINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQR NGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRL ELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFS HGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTIS VNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQ LPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQ SLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDG LILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKIT TQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRAD RLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS GGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQG QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLAT STARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSST TGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN KDKEYYV TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
![]() Sequencher program is needed, download here. |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_001135659 |
ORF Size | 4641 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001135659.1, NM_001135659.2, NP_001129131.1 |
RefSeq ORF | 4644 bp |
Locus ID | 9378 |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs) |
MW | 169.91 kDa |
Gene Summary | This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016] |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC326389 | NRXN1 (untagged)-Human neurexin 1 (NRXN1), transcript variant alpha2 |
USD 3,140.00 |
|
RG226688 | NRXN1 (GFP-tagged) - Human neurexin 1 (NRXN1), transcript variant alpha2 |
USD 1,600.00 |
|
RC226688L1 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, Myc-DDK-tagged |
USD 2,040.00 |
|
RC226688L2 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, mGFP tagged |
USD 1,650.00 |
|
RC226688L3 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, Myc-DDK-tagged |
USD 1,650.00 |
|
RC226688L4 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, mGFP tagged |
USD 1,650.00 |
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