KCNH6 (NM_001278920) Human Tagged ORF Clone

CAT#: RC239652

KCNH6 (myc-DDK-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6), transcript variant 4

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: KCNH6
• Synonyms: ERG-2; ERG2; hERG-2; HERG2; Kv11.2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC239652 representing NM_001278920
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTTCATTCTCAACTTCGAGGACCTGGCCCAGCTCCTGGCCAAGTGCAGCAGCCGCAGCTTGTCCCAGC
  GCCTGTTGTCCCAGAGCTTCCTGGGCTCCGAGGGCTCTCATGGCAGGCCAGGCGGACCAGGGCCAGGCAC
  AGGCAGGGGCAAGTACAGGACCATCAGCCAGATCCCACAGTTCACGCTCAACTTCGTGGAGTTCAACTTG
  GAGAAGCACCGCTCCAGCTCCACCACGGAGATTGAGATCATCGCGCCCCATAAGGTGGTGGAGCGGACAC
  AGAACGTCACTGAGAAGGTCACCCAGGTCCTGTCCCTGGGCGCGGATGTGCTGCCGGAGTACAAGCTGCA
  GGCGCCGCGCATCCACCGCTGGACCATCCTGCACTACAGCCCCTTCAAGGCCGTGTGGGACTGGCTCATC
  CTGCTGCTGGTCATCTACACGGCTGTCTTCACGCCCTACTCAGCCGCCTTCCTGCTCAGCGATCAGGACG
  AATCACGGCGTGGGGCCTGCAGCTATACCTGCAGTCCCCTCACTGTGGTGGATCTCATCGTGGACATCAT
  GTTCGTCGTGGACATCGTCATCAACTTCCGCACCACCTATGTCAACACCAATGATGAGGTGGTCAGCCAC
  CCCCGCCGCATCGCCGTCCACTACTTCAAGGGCTGGTTCCTCATTGACATGGTGGCCGCCATCCCTTTCG
  ACCTCCTGATCTTCCGCACTGGCTCCGATGAGACCACAACCCTGATTGGGCTATTGAAGACAGCGCGGCT
  GCTGCGGCTGGTGCGCGTAGCACGGAAGCTGGACCGCTACTCTGAGTATGGGGCGGCTGTGCTCTTCTTG
  CTCATGTGCACCTTCGCGCTCATAGCGCACTGGCTGGCCTGCATCTGGTACGCCATCGGCAATGTGGAGC
  GGCCCTACCTAGAACACAAGATCGGCTGGCTGGACAGCCTGGGTGTGCAGCTTGGCAAGCGCTACAACGG
  CAGCGACCCAGCCTCGGGCCCCTCGGTGCAGGACAAGTATGTCACAGCCCTCTACTTCACCTTCAGCAGC
  CTCACCAGCGTGGGCTTCGGCAATGTCTCGCCCAACACCAACTCCGAGAAGGTCTTCTCCATCTGCGTCA
  TGCTCATCGGCTCCCTGATGTACGCCAGCATCTTCGGGAACGTGTCCGCGATCATCCAGCGCCTGTACTC
  GGGCACCGCGCGCTACCACACGCAGATGCTGCGTGTCAAGGAGTTCATCCGCTTCCACCAGATCCCCAAC
  CCACTGCGCCAGCGCCTGGAGGAGTATTTCCAGCACGCCTGGTCCTACACCAATGGCATTGACATGAACG
  CGGTGCTGAAGGGCTTCCCCGAGTGCCTGCAGGCTGACATCTGCCTGCACCTGCACCGCGCACTGCTGCA
  GCACTGCCCAGCTTTCAGCGGCGCCGGCAAGGGCTGCCTGCGCGCGCTAGCCGTCAAGTTCAAGACCACC
  CACGCGCCGCCTGGGGACACGCTGGTGCACCTCGGCGACGTGCTCTCCACCCTCTACTTCATCTCCCGAG
  GCTCCATCGAGATCCTGCGCGACGACGTGGTCGTGGCCATCCTAGGAAAGAATGACATCTTTGGGGAACC
  CGTCAGCCTCCATGCCCAGCCAGGCAAGTCCAGTGCAGACGTGCGGGCTCTGACCTACTGCGACCTGCAC
  AAGATCCAGCGGGCAGATCTGCTGGAGGTGCTGGACATGTACCCGGCCTTTGCGGAGAGCTTCTGGAGTA
  AGCTGGAGGTCACCTTCAACCTGCGGGACGCAGCCGGGGGTCTCCACTCATCCCCCCGACAGGCTCCTGG
  CAGCCAAGACCACCAAGGTTTCTTTCTCAGTGACAACCAGTCAGATGCAGCCCCTCCCCTGAGCATCTCA
  GATGCATCTGGCCTCTGGCCTGAGCTACTGCAGGAAATGCCCCCAAGGCACAGCCCCCAAAGCCCTCAGG
  AAGACCCAGATTGCTGGCCTCTGAAGCTGGGCTCCAGGCTAGAGCAGCTCCAGGCCCAGATGAACAGGCT
  GGAGTCCCGCGTGTCCTCAGACCTCAGCCGCATCTTGCAGCTCCTCCAGAAGCCCATGCCCCAGGGCCAC
  GCCAGCTACATTCTGGAAGCCCCTGCCTCCAATGACCTGGCCTTGGTTCCTATAGCCTCGGAGACGACGA
  GTCCAGGGCCCAGGCTGCCCCAGGGCTTTCTGCCTCCTGCACAGACCCCAAGCTATGGAGACTTGGATGA
  CTGTAGTCCAAAGCACAGGAACTCCTCCCCCAGGATGCCTCACCTGGCTGTGGCAACGGACAAAACTCTG
  GCACCATCCTCAGAACAGGAACAGCCTGAGGGGCTCTGGCCACCCCTAGCCTCACCTCTACATCCCCTGG
  AAGTACAAGGACTCATCTGTGGTCCCTGCTTCTCCTCCCTCCCTGAACACCTTGGCTCTGTTCCCAAGCA
  GCTGGACTTCCAGAGACATGGCTCAGATCCTGGATTTGCAGGGAGTTGGGGCCAC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC239652 representing NM_001278920
  Red=Cloning site Green=Tags(s)
  
  MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNL
  EKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLI
  LLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSH
  PRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL
  LMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSS
  LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPN
  PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTT
  HAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLH
  KIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSIS
  DASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGH
  ASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTL
  APSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001278920
• ORF Size: 2505 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001278920.1, NP_001265849.1
• RefSeq Size: 3650
• RefSeq ORF: 2508
• Locus ID: 81033
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• MW: 93.2 kDa
• Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]