C10orf112 (MALRD1) (NM_001142308) Human Tagged ORF Clone

CAT#: RC240236

MALRD1 (myc-DDK-tagged) - Human MAM and LDL receptor class A domain containing 1 (MALRD1)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: MALRD1
• Synonyms: bA265G8.2; C10orf112; DIET1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC240236 representing NM_001142308
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCTCTTCTTCCTGGACAGAATGTTGGCATTCCCCATGAATGAAACTTTTTGTTGCCTTTGGATTGCCT
  GTGTTTTCAATTCTACACTGGCTCAGCAAGGGACAGAAAGCTTTCAGTGTGACAATGGAGTCTCCTTGCC
  TCCTGACAGCATTTGTGACTTCACAGATCAGTGTGGGGATAGCAGTGATGAACGGCACTGTTTGAATTAT
  GAAAGATGTGATTTTGAGGATGGTCTCTGTCATATGACTCAAGATCAGAGTCTGCAACCTAGTTGGACAA
  AGAGAAGTGGGATGATTGGTCTATCACCTCCATTTTATGATCACAATGGTGATGTGTCTGCTCACTTCCT
  CTCACTGGTTTCCAGAGTGGATTCTATTTCCTCAAGTTTAAGAAGCAGAGTTTTCCTTCCAACAAATGAT
  CAACATGACTGCCAGATTACATTTTATTACTTCTCCTGCCAAGTGAGTGGCAAATTAATGGTTGGGCTTC
  AAACTGCATGTGGAGGTCCTATTCAGCATTTATGGCAAAACACAGCTGCACTCCCAAATCAGTGGGAGAG
  AAATGTCATCAAAATCCAGAGTTCACAGAGATTTCAGGTTGTTTTTGAAGGTCAAATGGCTTCAACGTAT
  GAACAGGATGAAGTCATTGCTATTGATGATATATCTTTCAGTTCAGGCTGCTTGCCTGCCAATGATGGAA
  TTTTACTGTGTCAAGAAGCATTGAATGCTGAGCGGGAGCTATGCCATCCAGATACAGATCTCTGCAGATT
  TGATGCTACAGATGAAGAGTTGAGATTGTGTCAGGCCTGTGGGTTTGAATTTGACATGTGTGAGTGGACG
  TCAGAAGCATCTGCTGGCCAAATTTCCTGGATGCGCACAAAAGCGAGAGAGATCCCTGCATTCGAATCCA
  CACCTCAGCAGGATCAAGGAGGTGATGATGAAGGTTATTATGTATGGGTAGGCGCTAAGCATGGTTTCAC
  TCTTAACCATTTAGACAGCAGGGCTTACCTAAATAGCTCTGTGTGTCATTGCCTGGGCAAGAGCTGTCAT
  CTTCAATTCTATTATGCAATGGAAAGCAGTGTCCTGAGAGTAAGACTGTATAATAATAAGGAAGAAGAAA
  TATTTTGGACATACAACATATCAACTCACAGCCAATGGGTGAAAGCAGATGTGTTAATACCAGAAGATCT
  GAAGACATTTAAGATTATTTTTGAAGGGACTCTTTTGAGCCAGAGAAGTTTTATTGCCCTTGATCACCTC
  TGGGTCTATGCCTGTGGACAGACCCAATCCAGAAAGCTTTGCTCTGCAGACGAATTCCCTTGCACTAGTG
  GCCAGTGCATCGCCAAAGAATCTGTCTGTGACTCTCGGCAGGACTGCTCCGATGAGAGTGATGAAGACCC
  AGCAACTTGCTCAAAGCATCTCACCTGTGACTTTGAGTCGGGTTTCTGCGGTTGGGAGCCATTTCTCACA
  GAAGATTCACACTGGAAGCTGATGAAAGGATTGAATAATGGAGAGCACCACTTTCCTGCAGCTGATCACA
  CAGCAAACATAAATCATGGATCGTTTATTTATTTGGAGGCACAGCGCTCCCCCGGGGTGGCCAAGCTTGG
  AAGTCCTGTTCTTACAAAATTGCTCACTGCCTCTACCCCATGTCAGGTGCAGTTTTGGTATCATTTGTCT
  CAACATTCAAATCTCTCAGTTTTTACAAGAACGTCTCTAGATGGAAACTTGCAAAAGCAGGGCAAAATAA
  TCAGATTCTCCGAATCTCAGTGGAGCCACGCAAAAATTGATCTCATTGCAGAAGCGGGAGAATCTACTCT
  ACCTTTTCAGTTAATTTTGGAAGCTACTGTTTTGTCGTCAAATGCTACCGTTGCTCTAGATGACATCAGT
  GTGTCCCAGGAATGTGAAATTTCCTATAAATCACTACCAAGGACCAGTACACAAAGCAAGTTTTCCAAGT
  GTGACTTTGAAGCAAACAGCTGTGATTGGTTTGAAGCAATTAGTGGTGACCATTTTGACTGGATACGGAG
  CTCTCAGAGTGAACTTTCTGCTGATTTTGAGCACCAGGCTCCACCTCGGGATCATAGTCTCAACGCATCT
  CAAGGGCATTTTATGTTCATTCTGAAGAAAAGCAGCAGCTTGTGGCAAGTTGCTAAGCTTCAGAGCCCAA
  CTTTCAGCCAGACAGGACCTGGATGCATACTTTCCTTCTGGTTCTATAACTATGGCCTGTCAGTGGGAGC
  AGCTGAGCTGCAGCTACATATGGAAAATTCTCATGACTCAACAGTGATTTGGAGAGTATTATACAATCAG
  GGCAAACAATGGTTGGAGGCAACCATTCAGCTAGGGCGCCTTTCGCAGCCCTTCCATTTGTCACTAGATA
  AAGTCAGTCTGGGCATTTATGATGGGGTCTCAGCTATTGATGACATCCGATTTGAAAATTGTACTCTCCC
  TCTTCCTGCTGAGAGCTGTGAAGGGCTGGATCATTTCTGGTGTCGCCACACCAGGGCTTGCATAGAAAAG
  CTTCGGTTATGTGATCTGGTGGATGACTGTGGTGATCGTACTGATGAAGTCAACTGTGCACCTGAGCTGC
  AGTGTAACTTTGAAACTGGAATCTGTAACTGGGAACAAGATGCAAAAGATGACTTTGATTGGACCAGGAG
  CCAGGGTCCAACTCCAACACTTAACACAGGGCCAATGAAAGATAACACTCTGGGCACAGCTAAAGGACAC
  TATCTCTACATAGAATCTTCAGAGCCACAGGCTTTTCAAGACAGTGCTGCCTTACTCAGCCCAATCCTTA
  ATGCCACTGATACAAAAGGCTGCACCTTCCGCTTCTATTACCACATGTTTGGAAAGCGCATTTATAGGTT
  GGCAATCTACCAACGAATCTGGAGTGACTCAAGGGGACAGCTGCTGTGGCAGATATTTGGGAATCAAGGC
  AACAGATGGATTAGGAAACACCTCAACATTTCCAGCAGGCAGCCCTTTCAGATATTGGTGGAGGCTTCAG
  TGGGAGATGGCTTCACTGGAGATATTGCGATTGATGATCTGTCATTTATGGACTGCACCCTCTACCCTGG
  TAATTTGCCAGCAGACCTCCCAACTCCACCAGAAACGTCAGTTCCTGTAACATTACCTCCACACAACTGC
  ACAGACAATGAATTTATCTGCAGGTCTGATGGTCACTGCATTGAAAAAATGCAGAAATGTGATTTTAAAT
  ATGACTGCCCTGACAAATCAGATGAAGCATCCTGTGTTATGGAAGTTTGCAGCTTTGAGAAAAGAAGCCT
  GTGTAAATGGTATCAACCAATCCCAGTACATTTGCTTCAAGATTCAAACACATTCAGGTGGGGGCTTGGG
  AACGGGATCAGCATTCATCATGGGGAAGAAAACCACAGGCCATCAGTGGATCATACACAAAATACCACTG
  ATGGCTGGTACCTGTATGCTGACAGTTCTAATGGGAAATTTGGTGACACGGCTGACATTCTCACTCCTAT
  CATTTCACTCACGGGACCAAAATGTACCTTGGTGTTCTGGACACATATGAATGGGGCCACCGTTGGTTCT
  CTCCAGGTGCTCATCAAGAAAGATAACGTTACTTCTAAATTGTGGGCTCAAACTGGACAGCAAGGTGCAC
  AGTGGAAGAGAGCAGAAGTGTTTTTAGGCATTCGTTCACATACACAGATTGTCTTCAGAGCCAAACGTGG
  TATCAGTTACATAGGAGATGTAGCAGTGGATGATATTTCCTTCCAAGATTGCTCCCCTTTGCTTAGCCCA
  GAGAGAAAGTGTACTGATCATGAATTCATGTGTGCTAATAAGCACTGCATTGCCAAAGACAAGCTGTGTG
  ATTTTGTGAATGATTGTGCTGATAATTCAGATGAGACTACTTTCATTTGCCGTACCTCCAGTGGGCGCTG
  TGATTTCGAATTTGATCTTTGTTCCTGGAAGCAGGAGAAAGATGAGGACTTTGACTGGAACCTGAAAGCT
  AGCAGCATCCCTGCAGCAGGCACAGAGCCAGCAGCAGATCACACTTTGGGAAATTCATCTGGTCATTACA
  TCTTTATAAAGAGTTTGTTTCCTCAGCAGCCCATGAGAGCTGCCAGAATTTCAAGTCCAGTTATAAGTAA
  GAGAAGCAAAAACTGCAAGATTATTTTTCATTATCACATGTATGGAAATGGCATTGGGGCACTCACCTTA
  ATGCAGGTGTCAGTCACAAACCAAACGAAGGTTCTACTTAACCTCACTGTAGAACAAGGCAATTTCTGGC
  GGAGAGAAGAACTGTCACTGTTTGGTGATGAAGACTTCCAACTCAAATTTGAAGGTAGAGTTGGGAAAGG
  TCAGCGTGGAGACATTGCACTTGATGACATTGTGCTTACAGAAAATTGTCTATCACTCCATGATTCCGTG
  CAAGAAGAACTGGCAGTGCCTCTTCCAACAGGTTTCTGCCCACTTGGCTATAGGGAATGTCATAATGGAA
  AATGCTATAGGCTGGAACAAAGCTGTAACTTCGTAGATAACTGTGGAGATAATACTGATGAAAATGAGTG
  TGGTAGCTCCTGTACTTTTGAAAAAGGCTGGTGTGGCTGGCAAAACTCCCAGGCTGACAACTTTGATTGG
  GTTTTAGGGGTTGGCTCTCATCAAAGCTTAAGACCTCCCAAAGACCACACACTTGGAAATGAAAATGGGC
  ACTTCATGTATCTGGAAGCTACTGCAGTGGGCCTTCGGGGTGACAAAGCACACTTCAGGAGTACCATGTG
  GCGAGAATCCAGTGCAGCCTGCACCATGAGCTTCTGGTATTTCGTATCTGCAAAGGCCACAGGATCCATT
  CAGATTCTCATCAAGACAGAGAAAGGACTATCAAAAGTATGGCAAGAAAGTAAGCAGAACCCTGGTAATC
  ATTGGCAAAAGGCTGACATCCTGCTAGGAAAGTTAAGGAATTTTGAAGTCATATTTCAAGGTATCAGAAC
  AAGGGACCTGGGAGGAGGAGCTGCAATTGATGATATTGAATTTAAAAACTGCACAACTGTGGGAGAGATC
  TCTGAGCTTTGTCCGGAAATCACTGATTTTTTGTGCCGGGACAAGAAGTGCATTGCATCCCACCTTCTTT
  GTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGCTCACTGTGCACATTATACAAGCACAACAGG
  AAGCTGCAATTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGACTCTGAGGAT
  GACTTGGACTGGGCCATTGGCAGCAGAATTCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCCAG
  GTAGTGGTCAGCACTTCCTGTACGTCAACTCATCTGGCTCCAAGGAAGGATCCGTTGCCAGAATTACTAC
  TTCCAAATCCTTCCCAGCAAGCCTTGGAATGTGTACTGTTCGGTTCTGGTTCTACATGATTGATCCCAGG
  AGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACATCCTGGTGTGGTCAGTGATTG
  GAAATAAAAGAACGGGATGGACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTTAAGGTGGCATT
  TGAAGCTGATTTGGATGGAAATGAGGACATCTTTATTGCTCTTGATGACATCTCTTTTACCCCAGAGTGT
  GTGACTGGAGGTCCTGTCCCAGTGCAGCCATCACCCTGTGAAGCTGATCAGTTTTCTTGTATCTACACAC
  TCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGAAGACTGCATAGATGGATCTGATGAAATGGA
  TTGTCCTCTCAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCTACAGACGAGTGTATA
  CCTTCCCTCCTGCTATGCGATGGAGTGCCCGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAACA
  AAAGCTGTTCTAATGGAGCTCTGGTGTGTGCCTCCTCCAACAGCTGTATCCCAGCCCACCAGCGCTGTGA
  TGGTTTTGCCGACTGCATGGATTTCCAGCTTGATGAGTCCAGCTGCTCCGAATGTCCATTAAATTACTGC
  AGAAATGGTGGGACTTGTGTAGTGGAGAAAAATGGTCCTATGTGTCGATGTAGACAAGGCTGGAAAGGAA
  ATCGATGCCATATCAAGTTTAATCCTCCTGCTACAGACTTCACATACGCTCAGAATAATACATGGACTCT
  CCTGGGTATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTCTTGTGTTTTCTTGCAAACAGA
  AAGGTACCAATAAGGAAAACCGAGGGAAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAACTGGA
  GCAACCCAGAGAAAACAGAGAGTTCTGTCTATTCCTTCTCAAACCCATTATATGGCACAACATCAGGAAG
  CCTGGAGACCCTGTCACATCATCTCAAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC240236 representing NM_001142308
  Red=Cloning site Green=Tags(s)
  
  MLFFLDRMLAFPMNETFCCLWIACVFNSTLAQQGTESFQCDNGVSLPPDSICDFTDQCGDSSDERHCLNY
  ERCDFEDGLCHMTQDQSLQPSWTKRSGMIGLSPPFYDHNGDVSAHFLSLVSRVDSISSSLRSRVFLPTND
  QHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQWERNVIKIQSSQRFQVVFEGQMASTY
  EQDEVIAIDDISFSSGCLPANDGILLCQEALNAERELCHPDTDLCRFDATDEELRLCQACGFEFDMCEWT
  SEASAGQISWMRTKAREIPAFESTPQQDQGGDDEGYYVWVGAKHGFTLNHLDSRAYLNSSVCHCLGKSCH
  LQFYYAMESSVLRVRLYNNKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFIALDHL
  WVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCGWEPFLT
  EDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVAKLGSPVLTKLLTASTPCQVQFWYHLS
  QHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIAEAGESTLPFQLILEATVLSSNATVALDDIS
  VSQECEISYKSLPRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNAS
  QGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQ
  GKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEK
  LRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPTPTLNTGPMKDNTLGTAKGH
  YLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQG
  NRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNC
  TDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLG
  NGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGS
  LQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSP
  ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKA
  SSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTL
  MQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSV
  QEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDW
  VLGVGSHQSLRPPKDHTLGNENGHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKATGSI
  QILIKTEKGLSKVWQESKQNPGNHWQKADILLGKLRNFEVIFQGIRTRDLGGGAAIDDIEFKNCTTVGEI
  SELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSED
  DLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPR
  SMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPEC
  VTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECI
  PSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSECPLNYC
  RNGGTCVVEKNGPMCRCRQGWKGNRCHIKFNPPATDFTYAQNNTWTLLGIGLAFLMTHITVAVLCFLANR
  KVPIRKTEGSGNCAFVNPVYGNWSNPEKTESSVYSFSNPLYGTTSGSLETLSHHLK
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001142308
• ORF Size: 6468 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001142308.2, NP_001135780.2
• RefSeq Size: 6880
• RefSeq ORF: 6471
• Locus ID: 340895
• Protein Families: Druggable Genome
• MW: 241.5 kDa
• Gene Summary: This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]