CLN6 (NM_017882) Human Tagged ORF Clone

CAT#: RG201904

CLN6 (GFP-tagged) - Human ceroid-lipofuscinosis, neuronal 6, late infantile, variant (CLN6)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: CLN6
• Synonyms: CLN4A; HsT18960; nclf
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG201904 representing NM_017882
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCT
  TCCTGCAGGCCAGGCATGGCTCTGTGAGCGCTGATGAGGCTGCCCGCACGGCTCCCTTCCACCTCGACCT
  CTGGTTCTACTTCACACTGCAGAACTGGGTTCTGGACTTTGGGCGTCCCATTGCCATGCTGGTATTCCCT
  CTCGAGTGGTTTCCACTCAACAAGCCCAGTGTTGGGGACTACTTCCACATGGCCTACAACGTCATCACGC
  CCTTTCTCTTGCTCAAGCTCATCGAGCGGTCCCCCCGCACCCTGCCACGCTCCATCACGTACGTGAGCAT
  CATCATCTTCATCATGGGTGCCAGCATCCACCTGGTGGGTGACTCTGTCAACCACCGCCTGCTCTTCAGT
  GGCTACCAGCACCACCTGTCTGTCCGTGAGAACCCCATCATCAAGAATCTCAAGCCGGAGACGCTGATCG
  ACTCCTTTGAGCTGCTCTACTATTATGATGAGTACCTGGGTCACTGCATGTGGTACATCCCCTTCTTCCT
  CATCCTCTTCATGTACTTCAGCGGCTGCTTTACTGCCTCTAAAGCTGAGAGCTTGATTCCAGGGCCTGCC
  CTGCTCCTGGTGGCACCCAGTGGCCTGTACTACTGGTACCTGGTCACCGAGGGCCAGATCTTCATCCTCT
  TCATCTTCACCTTCTTCGCCATGCTGGCCCTCGTCCTGCACCAGAAGCGCAAGCGCCTCTTCCTGGACAG
  CAACGGCCTCTTCCTCTTCTCCTCCTTCGCACTGACCCTCTTGCTTGTGGCGCTCTGGGTCGCCTGGCTG
  TGGAATGACCCTGTTCTCAGGAAGAAGTACCCGGGTGTCATCTACGTCCCTGAGCCCTGGGCTTTCTACA
  CCCTTCACGTCAGCAGTCGGCAC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG201904 representing NM_017882
  Red=Cloning site Green=Tags(s)
  
  MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFP
  LEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFS
  GYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPA
  LLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWL
  WNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_017882
• ORF Size: 933 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_017882.1, NP_060352.1
• RefSeq Size: 2227
• RefSeq ORF: 936
• Locus ID: 54982
• Protein Families: Transmembrane
• Gene Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]