TAB3 (NM_152787) Human Tagged ORF Clone

CAT#: RG207646

TAB3 (GFP-tagged) - Human TGF-beta activated kinase 1/MAP3K7 binding protein 3 (TAB3)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: TAB3
• Synonyms: MAP3K7IP3; NAP1
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG207646 representing NM_152787
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGCAAAGCAGCCCACAGCTTGATATTCAGGTTCTCCATGATCTTCGACAACGTTTCCCTGAAATTC
  CAGAGGGCGTGGTGTCTCAGTGCATGTTACAGAATAACAACAATCTTGAAGCCTGTTGCCGAGCCCTTTC
  CCAGGAGAGTAGCAAATACTTATATATGGAATACCATAGTCCAGATGACAATAGGATGAATAGAAATCGC
  CTTTTACATATTAACCTGGGTATCCATTCTCCTAGTAGCTATCACCCAGGAGATGGAGCCCAACTTAATG
  GTGGTCGAACACTGGTACATAGCTCAAGTGATGGACATATTGATCCTCAGCATGCAGCAGGTAAACAGCT
  GATATGTTTAGTTCAAGAACCACACTCAGCTCCAGCTGTTGTTGCTGCTACTCCCAACTACAATCCATTT
  TTTATGAACGAACAGAACAGAAGTGCAGCTACTCCTCCTTCACAACCACCTCAACAGCCATCTTCCATGC
  AAACAGGAATGAATCCGTCTGCTATGCAAGGGCCTTCACCACCACCGCCACCTCCTTCATACATGCACAT
  ACCTCGGTATAGTACAAATCCAATTACTGTTACAGTATCCCAGAACCTCCCTTCTGGACAGACTGTACCA
  AGAGCTTTACAAATTCTTCCACAAATTCCAAGCAATCTCTATGGGTCTCCTGGTTCTATTTATATTAGAC
  AGACATCTCAGAGTTCATCAGGAAGACAAACTCCTCAGAGTACGCCGTGGCAGTCCTCACCACAGGGCCC
  AGTGCCTCACTATAGCCAGCGTCCTTTACCTGTTTATCCACACCAACAGAACTATCAGCCTTCTCAGTAT
  TCTCCCAAACAGCAGCAGATCCCTCAGTCTGCTTACCATTCACCACCTCCTTCTCAATGTCCTTCACCCT
  TCAGCTCTCCACAGCATCAAGTGCAACCTTCCCAGTTGGGCCACATCTTTATGCCACCTAGTCCTTCAAC
  TACTCCACCCCATCCATATCAACAAGGACCTCCTAGCTATCAGAAACAGGGAAGCCATTCAGTAGCCTAT
  CTTCCATACACAGCATCTAGTTTATCCAAAGGTTCCATGAAGAAGATAGAAATTACAGTTGAACCTTCTC
  AAAGACCTGGGACAGCAATTAATAGGAGTCCTTCACCCATCAGTAATCAACCATCTCCACGGAATCAACA
  CTCACTGTACACAGCCACCACGCCACCTTCAAGTTCTCCTTCAAGAGGGATATCTAGTCAACCAAAACCT
  CCATTTAGTGTTAATCCTGTGTATATTACATATACACAGCCAACTGGACCTTCTTGTACTCCATCACCAT
  CTCCTCGAGTGATACCAAACCCAACTACAGTTTTTAAAATTACCGTAGGCCGAGCAACGACTGAAAATCT
  TTTAAATTTAGTGGACCAAGAAGAGCGCTCTGCAGCACCAGAACCTATTCAGCCCATTTCAGTGATACCA
  GGCTCTGGGGGAGAAAAGGGAAGCCATAAATATCAGAGAAGTTCTAGTTCTGGATCAGATGACTATGCCT
  ACACACAAGCCTTGCTGTTACATCAACGAGCAAGGATGGAGAGGTTAGCAAAGCAACTGAAACTTGAGAA
  AGAGGAGCTAGAGCGGTTGAAGTCTGAAGTTAATGGTATGGAGCATGACCTGATGCAGAGACGGCTCAGA
  AGAGTCAGCTGCACCACTGCGATCCCTACGCCTGAGGAAATGACAAGATTGAGAAGCATGAACAGACAAC
  TCCAGATAAATGTTGACTGTACACTGAAAGAAGTTGACCTCCTTCAATCTAGAGGAAACTTTGATCCAAA
  AGCCATGAATAATTTTTATGACAACATAGAACCTGGCCCAGTTGTACCACCCAAGCCATCTAAAAAAGAC
  TCCTCAGACCCCTGCACAATTGAGAGAAAAGCCCGAAGAATTAGCGTGACCTCCAAAGTACAGGCAGACA
  TCCATGACACCCAGGCAGCAGCTGCAGATGAGCATCGAACTGGCTCCACACAAAGTCCTCGGACACAACC
  TCGAGATGAAGACTACGAAGGGGCTCCATGGAATTGTGATAGCTGCACCTTTCTTAACCACCCAGCACTA
  AATCGCTGTGAGCAGTGCGAGATGCCACGGTACACC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG207646 representing NM_152787
  Red=Cloning site Green=Tags(s)
  
  MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNR
  LLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPF
  FMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVP
  RALQILPQIPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQY
  SPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAY
  LPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKP
  PFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIP
  GSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLR
  RVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPPKPSKKD
  SSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPAL
  NRCEQCEMPRYT
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_152787
• ORF Size: 2136 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_152787.3, NP_690000.2
• RefSeq Size: 6798
• RefSeq ORF: 2139
• Locus ID: 257397
• Domains: zf-RanBP, CUE
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway
• Gene Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]