CACNG2 (NM_006078) Human Tagged ORF Clone

CAT#: RG222266

CACNG2 (GFP-tagged) - Human calcium channel, voltage-dependent, gamma subunit 2 (CACNG2)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: CACNG2
• Synonyms: MRD10
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG222266 representing NM_006078
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGCTGTTTGATCGAGGTGTTCAAATGCTTTTAACCACCGTTGGTGCTTTCGCTGCCTTCAGCCTGA
  TGACCATAGCTGTGGGAACCGACTATTGGCTCTACTCCAGAGGGGTTTGCAAGACCAAAAGTGTCAGTGA
  GAATGAAACCAGCAAAAAGAACGAGGAAGTTATGACCCATTCCGGATTATGGAGAACCTGCTGCCTAGAA
  GGGAATTTCAAAGGTCTGTGCAAGCAAATTGATCACTTCCCAGAGGATGCAGATTACGAAGCTGACACAG
  CAGAATATTTCCTCCGGGCCGTGAGGGCCTCCAGCATTTTCCCAATCCTGAGTGTGATTCTGCTTTTCAT
  GGGTGGCCTCTGCATCGCAGCCAGCGAGTTCTACAAAACTCGACACAACATCATCCTGAGTGCCGGCATC
  TTCTTCGTGTCTGCAGGTCTGAGTAACATCATTGGCATCATAGTGTACATATCTGCCAATGCCGGAGACC
  CCTCCAAGAGCGACTCCAAAAAGAATAGTTACTCATACGGCTGGTCCTTCTACTTCGGGGCCCTGTCCTT
  CATCATCGCCGAGATGGTCGGGGTGCTGGCGGTGCACATGTTTATCGACCGGCACAAACAGCTGCGGGCC
  ACGGCCCGCGCCACGGACTACCTCCAGGCCTCTGCCATCACCCGCATCCCCAGCTACCGCTACCGCTACC
  AGCGCCGCAGCCGCTCCAGCTCGCGCTCCACGGAGCCCTCACACTCCAGGGACGCCTCCCCCGTGGGCAT
  CAAGGGCTTCAACACCCTGCCGTCCACGGAGATCTCCATGTACACGCTCAGCAGGGACCCCCTGAAGGCC
  GCCACCACGCCCACCGCCACCTACAACTCCGACAGGGATAACAGCTTCCTCCAGGTTCACAACTGTATCC
  AGAAGGAGAACAAGGACTCTCTCCACTCCAACACAGCCAACCGCCGGACCACCCCCGTA
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG222266 representing NM_006078
  Red=Cloning site Green=Tags(s)
  
  MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLE
  GNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGI
  FFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRA
  TARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKA
  ATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_006078
• ORF Size: 969 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006078.2, NP_006069.1
• RefSeq Size: 1548
• RefSeq ORF: 972
• Locus ID: 10369
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway
• Gene Summary: The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability. [provided by RefSeq, Jul 2017]