ELAC2 (NM_173717) Human Tagged ORF Clone

CAT#: RG229023

ELAC2 (GFP-tagged) - Human elaC homolog 2 (E. coli) (ELAC2), transcript variant 2

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: ELAC2
• Synonyms: COXPD17; ELC2; HPC2
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG229023 representing NM_173717
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTGGGCGCTTTGCTCGCTGCTGCGGTCCGCGGCCGGACGCACCATGTCGCAGGGACGCACCATATCGC
  AGGCACCCGCCCGCCGCGAGCGGCCGCGCAAGGACCCGCTGCGGCACCTGCGCACGCGAGAGAAGCGCGG
  ACCGTCGGGGTGCTCCGGCGGCCCAAACACCGTGTACCTGCAGGTGGTGGCAGCGGGTAGCCGGGACTCG
  GGCGCCGCGCTCTACGTCTTCTCCGAGTTCAACCGGTATCTCTTCAACTGTGGAGAAGGCGTTCAGAGAC
  TCATGCAGGAGCACAAGTTAAAGGTTGCTCGCCTGGACAACATATTCCTGACACGAATGCACTGGTCTAA
  TGTTGGGGGCTTAAGTGGAATGATTCTTACTTTAAAGGAAACCGGGCTTCCAAAGTGTGTACTTTCTGGA
  CCTCCACAACTGGAAAAATACCTCGAAGCAATCAAAATATTTTCTGGTCCATTGAAAGGAATAGAACTGG
  CTGTGCGGCCCCACTCTGCCCCAGAATACGAGGATGAAACCATGACAGTTTACCAGATCCCCATACACAG
  TGAACAGAGGAGGGGAAAGCACCAACCATGGCAGAGTCCAGAAAGGCCTCTCAGCAGGCTCAGTCCAGAG
  CGATCTTCAGACTCCGAGTTGAATGAAAATGAGCCACACCTTCCACATGGTGTTAGCCAGAGAAGAGGGG
  TCAGGGACTCTTCCCTGGTCGTAGCTTTCATCTGTAAGCTTCACTTAAAGAGAGGAAACTTCTTGGTGCT
  CAAAGCAAAGGAGATGGGCCTCCCAGTTGGGACAGCTGCCATCGCTCCCATCATTGCTGCTGTCAAGGAC
  GGGAAAAGCATCACTCATGAAGGAAGAGAGATTTTGGCTGAAGAGCTGTGTACTCCTCCAGATCCTGGTG
  CTGCTTTTGTGGTGGTAGAATGTCCAGATGAAAGCTTCATTCAACCCATCTGTGAGAATGCCACCTTTCA
  GAGGTACCAAGGAAAGGCAGATGCCCCCGTGGCCTTGGTGGTTCACATGGCCCCAGCATCTGTGCTTGTG
  GACAGCAGGTACCAGCAGTGGATGGAGAGGTTTGGGCCTGACACCCAGCACTTGGTCCTGAATGAGAACT
  GTGCCTCAGTTCACAACCTTCGCAGCCACAAGATTCAAACCCAGCTCAACCTCATCCACCCGGACATCTT
  CCCCCTGCTCACCAGTTTCCGCTGTAAGAAGGAGGGCCCCACCCTCAGTGTGCCCATGGTTCAGGGTGAA
  TGCCTCCTCAAGTACCAGCTCCGTCCCAGGAGGGAGTGGCAGAGGGATGCCATTATTACTTGCAATCCTG
  AGGAATTCATAGTTGAGGCGCTGCAGCTTCCCAACTTCCAGCAGAGCGTGCAGGAGTACAGGAGGAGTGC
  GCAGGACGGCCCAGCCCCAGCAGAGAAAAGAAGTCAGTACCCAGAAATCATCTTCCTTGGAACAGGGTCT
  GCCATCCCGATGAAGATTCGAAATGTCAGTGCCACACTTGTCAACATAAGCCCCGACACGTCTCTGCTAC
  TGGACTGTGGTGAGGGCACGTTTGGGCAGCTGTGCCGTCATTACGGAGACCAGGTGGACAGGGTCCTGGG
  CACCCTGGCTGCTGTGTTTGTGTCCCACCTGCACGCAGATCACCACACGGGCTTGCCAAGTATCTTGCTG
  CAGAGAGAACGCGCCTTGGCATCTTTGGGAAAGCCGCTTCACCCTTTGCTGGTGGTTGCCCCCAACCAGC
  TCAAAGCCTGGCTCCAGCAGTACCACAACCAGTGCCAGGAGGTCCTGCACCACATCAGTATGATTCCTGC
  CAAATGCCTTCAGGAAGGGGCTGAGATCTCCAGTCCTGCAGTGGAAAGATTGATCAGTTCGCTGTTGCGA
  ACATGTGATTTGGAAGAGTTTCAGACCTGTCTGGTGCGGCACTGCAAGCATGCGTTTGGCTGTGCGCTGG
  TGCACACCTCTGGCTGGAAAGTGGTCTATTCCGGGGACACCATGCCCTGCGAGGCTCTGGTCCGGATGGG
  GAAAGATGCCACCCTCCTGATACATGAAGCCACCCTGGAAGATGGTTTGGAAGAGGAAGCAGTGGAAAAG
  ACACACAGCACAACGTCCCAAGCCATCAGCGTGGGGATGCGGATGAACGCGGAGTTCATTATGCTGAACC
  ACTTCAGCCAGCGCTATGCCAAGGTCCCCCTCTTCAGCCCCAACTTCAGCGAGAAAGTGGGAGTTGCCTT
  TGACCACATGAAGGTCTGCTTTGGAGACTTTCCAACAATGCCCAAGCTGATTCCCCCACTGAAAGCCCTG
  TTTGCTGGCGACATCGAGGAGATGGAGGAGCGCAGGGAGAAGCGGGAGCTGCGGCAGGTGCGGGCGGCCC
  TCCTGTCCAGGGAGCTGGCAGGCGGCCTGGAGGATGGGGAGCCTCAGCAGAAGCGGGCCCACACAGAGGA
  GCCACAGGCCAAGAAGGTCAGAGCCCAG
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG229023 representing NM_173717
  Red=Cloning site Green=Tags(s)
  
  MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDS
  GAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSG
  PPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPE
  RSSDSELNENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKD
  GKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKADAPVALVVHMAPASVLV
  DSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGE
  CLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGS
  AIPMKIRNVSATLVNISPDTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILL
  QRERALASLGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLR
  TCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAVEK
  THSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFSEKVGVAFDHMKVCFGDFPTMPKLIPPLKAL
  FAGDIEEMEERREKRELRQVRAALLSRELAGGLEDGEPQQKRAHTEEPQAKKVRAQ
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_173717
• ORF Size: 2475 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_173717.1, NP_776065.1
• RefSeq Size: 3811
• RefSeq ORF: 2478
• Locus ID: 60528
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Gene Summary: The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]