ARNTL2 (NM_001248004) Human Tagged ORF Clone

CAT#: RG234501

ARNTL2 (GFP-tagged) - Homo sapiens aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2), transcript variant 4

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: ARNTL2
• Synonyms: bHLHe6; BMAL2; CLIF; MOP9; PASD9
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG234501 representing NM_001248004
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGGCGGAAGAGGAGGCTGCGGCGGGAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTG
  TGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATGACAGA
  GTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAGCCAAACTGAAAAGCGG
  AGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGC
  GTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAA
  TTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAG
  ACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCT
  CCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGA
  TGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAA
  ACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTT
  TTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAA
  GAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTT
  GGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGAT
  TACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTT
  TGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAA
  CTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAG
  CAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGT
  AACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTC
  AACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAG
  AAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAG
  TATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGAT
  TCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGT
  TTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCA
  CAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACA
  GCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACA
  TCCAGTGGACCCTC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG234501 representing NM_001248004
  Red=Cloning site Green=Tags(s)
  
  MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKR
  RRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILK
  TAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAK
  TGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIV
  GMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQE
  LLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSV
  NTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDD
  SSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDT
  AMAAFMNYLEAEGGLGDPGDFSDIQWTL
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001248004
• ORF Size: 1764 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001248004.1, NP_001234933.1
• RefSeq Size: 7267
• RefSeq ORF: 1767
• Locus ID: 56938
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]