ARNTL2 (NM_001248002) Human Tagged ORF Clone

CAT#: RG234591

ARNTL2 (GFP-tagged) - Homo sapiens aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2), transcript variant 2

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: ARNTL2
• Synonyms: bHLHe6; BMAL2; CLIF; MOP9; PASD9
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG234591 representing NM_001248002
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGGCGGAAGAGGAGGCTGCGGCGGGAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTG
  TGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATGACAGA
  GTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAGTCAGGAATCATGACAGAAAAAGTGGTG
  GAAAAGCTTTCTCAGAATCCCCTTACCTATCTTCTTTCAACAAGGATAGAAATATCAGCCTCCAGTGGCA
  GCAGAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTC
  TGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTT
  CAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTC
  AGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAG
  AGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGA
  CAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATA
  TTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAG
  GACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAA
  GAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTG
  GTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAG
  TAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATT
  AATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGG
  CAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGA
  TGACCACAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCC
  TACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTT
  GGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGC
  ATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGA
  ATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTAC
  AGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGT
  AAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCT
  ACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGG
  ATTTCGATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGG
  GGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAGTGGACCCTC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG234591 representing NM_001248002
  Red=Cloning site Green=Tags(s)
  
  MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVV
  EKLSQNPLTYLLSTRIEISASSGSREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAV
  QHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTG
  QSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVK
  EEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEI
  NVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDS
  YKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPG
  MSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEA
  TRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001248002
• ORF Size: 1866 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001248002.1, NP_001234931.1
• RefSeq Size: 7369
• RefSeq ORF: 1869
• Locus ID: 56938
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]