NMDAR2C (GRIN2C) (NM_001278553) Human Tagged ORF Clone

CAT#: RG239716

  • TrueORF®

GRIN2C (GFP-tagged) - Human glutamate receptor, ionotropic, N-methyl D-aspartate 2C (GRIN2C), transcript variant 2


Reconstitution Protocol

USD 790.00

2 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Tag TurboGFP
Symbol GRIN2C
Synonyms GluN2C; NMDAR2C; NR2C
Vector pCMV6-AC-GFP
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RG239716 representing NM_001278553.
Blue=ORF Red=Cloning site Green=Tag(s)

GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
ATGGGTGGGGCCCTGGGGCCGGCCCTGTTGCTCACCTCGCTCTTCGGTGCCTGGGCAGGGCTGGGTCCG
GGGCAGGGCGAGCAGGGCATGACGGTGGCCGTGGTGTTTAGCAGCTCAGGGCCGCCCCAGGCCCAGTTC
CGTGCCCGCCTCACCCCCCAGAGCTTCCTGGACCTACCCCTGGAGATCCAGCCGCTCACAGTTGGGGTC
AACACCACCAACCCCAGCAGCCTCCTCACCCAGATCTGCGGCCTCCTGGGTGCTGCCCACGTCCACGGC
ATTGTCTTTGAGGACAACGTGGACACCGAGGCGGTGGCCCAGATCCTTGACTTCATCTCCTCCCAGACC
CATGTGCCCATCCTCAGCATCAGCGGAGGCTCTGCTGTGGTCCTCACCCCCAAGGAGCCGGGCTCCGCC
TTCCTGCAGCTGGGCGTGTCCCTGGAGCAGCAGCTGCAGGTGCTGTTCAAGGTGCTGGAAGAGTACGAC
TGGAGCGCCTTCGCCGTCATCACCAGCCTGCACCCGGGCCACGCGCTCTTCCTGGAGGGCGTGCGCGCC
GTCGCCGACGCCAGCCACGTGAGTTGGCGGCTGCTGGACGTGGTCACGCTGGAGCTGGGCCCGGGAGGG
CCGCGCGCGCGCACGCAGCGCCTGCTGCGCCAGCTCGACGCGCCCGTGTTTGTGGCCTACTGCTCGCGC
GAGGAGGCCGAGGTGCTCTTCGCCGAGGCGGCGCAGGCCGGTCTGGTGGGGCCCGGCCACGTGTGGCTG
GTGCCCAACCTGGCGCTGGGCAGCACCGATGCGCCCCCCGCCACCTTCCCCGTGGGCCTCATCAGCGTC
GTCACCGAGAGCTGGCGCCTCAGCCTGCGCCAGAAGGTGCGCGACGGCGTGGCCATTCTGGCCCTGGGC
GCCCACAGCTACTGGCGCCAGCATGGAACCCTGCCAGCCCCGGCCGGGGACTGCCGTGTTCACCCTGGG
CCCGTCAGCCCTGCCCGGGAGGCCTTCTACAGGCACCTACTGAATGTCACCTGGGAGGGCCGAGACTTC
TCCTTCAGCCCTGGTGGGTACCTGGTCCAGCCCACCATGGTGGTGATCGCCCTCAACCGGCACCGCCTC
TGGGAGATGGTGGGGCGCTGGGAGCATGGCGTCCTATACATGAAGTACCCCGTGTGGCCTCGCTACAGT
GCCTCTCTGCAGCCTGTGGTGGACAGTCGGCACCTGACGGTGGCCACGCTGGAAGAGCGGCCCTTTGTC
ATCGTGGAGAGCCCTGACCCTGGCACAGGAGGCTGTGTCCCCAACACCGTGCCCTGCCGCAGGCAGAGC
AACCACACCTTCAGCAGCGGGGACGTGGCCCCCTACACCAAGCTCTGCTGTAAGGGATTCTGCATCGAC
ATCCTCAAGAAGCTGGCCAGAGTGGTCAAATTCTCCTACGACCTGTACCTGGTGACCAACGGCAAGCAT
GGCAAGCGGGTGCGCGGCGTATGGAACGGCATGATTGGGGAGGTGTACTACAAGCGGGCAGACATGGCC
ATCGGCTCCCTCACCATCAATGAGGAACGCTCCGAGATCGTAGACTTCTCTGTACCCTTTGTGGAGACG
GGCATCAGTGTGATGGTGGCTCGCAGCAATGGCACCGTCTCCCCCTCGGCCTTCTTGGAGCCATATAGC
CCTGCAGTGTGGGTGATGATGTTTGTCATGTGCCTCACTGTGGTGGCCATCACCGTCTTCATGTTCGAG
TACTTCAGCCCTGTCAGCTACAACCAGAACCTCACCAGAGGCAAGAAGTCCGGGGGCCCAGCTTTCACT
ATCGGCAAGTCCGTGTGGCTGCTGTGGGCGCTGGTCTTCAACAACTCAGTGCCCATCGAGAACCCGCGG
GGCACCACCAGCAAGATCATGGTTCTGGTCTGGGCCTTCTTTGCTGTCATCTTCCTCGCCAGCTACACG
GCCAACCTGGCCGCCTTCATGATCCAAGAGCAATACATCGACACTGTGTCGGGCCTCAGTGACAAGAAG
TTTCAGCGGCCTCAAGATCAGTACCCACCTTTCCGCTTCGGCACGGTGCCCAACGGCAGCACGGAGCGG
AACATCCGCAGTAACTACCGTGACATGCACACCCACATGGTCAAGTTCAACCAGCGCTCGGTGGAGGAC
GCGCTCACCAGCCTCAAGATGGGGAAGCTGGATGCCTTCATCTATGATGCTGCTGTCCTCAACTACATG
GCAGGCAAGGACGAGGGCTGCAAGCTGGTCACCATTGGGTCTGGCAAGGTCTTTGCTACCACTGGCTAC
GGCATCGCCATGCAGAAGGACTCCCACTGGAAGCGGGCCATAGACCTGGCGCTCTTGCAGTTCCTGGGG
GACGGAGAGACACAGAAACTGGAGACAGTGTGGCTCTCAGGGATCTGCCAGAATGAGAAGAACGAGGTG
ATGAGCAGCAAGCTGGACATCGACAACATGGCAGGCGTCTTCTACATGCTGCTGGTGGCCATGGGGCTG
GCCCTGCTGGTCTTCGCCTGGGAGCACCTGGTCTACTGGAAGCTGCGCCACTCGGTGCCCAACTCATCC
CAGCTGGACTTCCTGCTGGCTTTCAGCAGGGTGGGTGCCCACCCCTCCCCACACAGGCCAAAGTTT

ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC
>Peptide sequence encoded by RG239716
Blue=ORF Red=Cloning site Green=Tag(s)

MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGV
NTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSA
FLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGG
PRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISV
VTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDF
SFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFV
IVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKH
GKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYS
PAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPR
GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTER
NIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGY
GIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGL
ALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRVGAHPSPHRPKF

TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV
MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED
SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA
FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV

Chromatograms CHROMATOGRAMS
Sequencher program is needed, download here.
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
ACCN NM_001278553
ORF Size 2619 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Reference Data
RefSeq NM_001278553.1, NP_001265482.1
RefSeq Size 3269 bp
RefSeq ORF 2622 bp
Locus ID 2905
Cytogenetics 17q25.1
Protein Families Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Long-term potentiation, Neuroactive ligand-receptor interaction
MW 96.4 kDa
Gene Summary 'This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]'

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