C10orf112 (MALRD1) (NM_001142308) Human Tagged ORF Clone

CAT#: RG240236

MALRD1 (GFP-tagged) - Human MAM and LDL receptor class A domain containing 1 (MALRD1)

Specifications

Product Data

• Tag: TurboGFP
• Symbol: MALRD1
• Synonyms: bA265G8.2; C10orf112; DIET1
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG240236 representing NM_001142308.
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGCTCTTCTTCCTGGACAGAATGTTGGCATTCCCCATGAATGAAACTTTTTGTTGCCTTTGGATTGCC
  TGTGTTTTCAATTCTACACTGGCTCAGCAAGGGACAGAAAGCTTTCAGTGTGACAATGGAGTCTCCTTG
  CCTCCTGACAGCATTTGTGACTTCACAGATCAGTGTGGGGATAGCAGTGATGAACGGCACTGTTTGAAT
  TATGAAAGATGTGATTTTGAGGATGGTCTCTGTCATATGACTCAAGATCAGAGTCTGCAACCTAGTTGG
  ACAAAGAGAAGTGGGATGATTGGTCTATCACCTCCATTTTATGATCACAATGGTGATGTGTCTGCTCAC
  TTCCTCTCACTGGTTTCCAGAGTGGATTCTATTTCCTCAAGTTTAAGAAGCAGAGTTTTCCTTCCAACA
  AATGATCAACATGACTGCCAGATTACATTTTATTACTTCTCCTGCCAAGTGAGTGGCAAATTAATGGTT
  GGGCTTCAAACTGCATGTGGAGGTCCTATTCAGCATTTATGGCAAAACACAGCTGCACTCCCAAATCAG
  TGGGAGAGAAATGTCATCAAAATCCAGAGTTCACAGAGATTTCAGGTTGTTTTTGAAGGTCAAATGGCT
  TCAACGTATGAACAGGATGAAGTCATTGCTATTGATGATATATCTTTCAGTTCAGGCTGCTTGCCTGCC
  AATGATGGAATTTTACTGTGTCAAGAAGCATTGAATGCTGAGCGGGAGCTATGCCATCCAGATACAGAT
  CTCTGCAGATTTGATGCTACAGATGAAGAGTTGAGATTGTGTCAGGCCTGTGGGTTTGAATTTGACATG
  TGTGAGTGGACGTCAGAAGCATCTGCTGGCCAAATTTCCTGGATGCGCACAAAAGCGAGAGAGATCCCT
  GCATTCGAATCCACACCTCAGCAGGATCAAGGAGGTGATGATGAAGGTTATTATGTATGGGTAGGCGCT
  AAGCATGGTTTCACTCTTAACCATTTAGACAGCAGGGCTTACCTAAATAGCTCTGTGTGTCATTGCCTG
  GGCAAGAGCTGTCATCTTCAATTCTATTATGCAATGGAAAGCAGTGTCCTGAGAGTAAGACTGTATAAT
  AATAAGGAAGAAGAAATATTTTGGACATACAACATATCAACTCACAGCCAATGGGTGAAAGCAGATGTG
  TTAATACCAGAAGATCTGAAGACATTTAAGATTATTTTTGAAGGGACTCTTTTGAGCCAGAGAAGTTTT
  ATTGCCCTTGATCACCTCTGGGTCTATGCCTGTGGACAGACCCAATCCAGAAAGCTTTGCTCTGCAGAC
  GAATTCCCTTGCACTAGTGGCCAGTGCATCGCCAAAGAATCTGTCTGTGACTCTCGGCAGGACTGCTCC
  GATGAGAGTGATGAAGACCCAGCAACTTGCTCAAAGCATCTCACCTGTGACTTTGAGTCGGGTTTCTGC
  GGTTGGGAGCCATTTCTCACAGAAGATTCACACTGGAAGCTGATGAAAGGATTGAATAATGGAGAGCAC
  CACTTTCCTGCAGCTGATCACACAGCAAACATAAATCATGGATCGTTTATTTATTTGGAGGCACAGCGC
  TCCCCCGGGGTGGCCAAGCTTGGAAGTCCTGTTCTTACAAAATTGCTCACTGCCTCTACCCCATGTCAG
  GTGCAGTTTTGGTATCATTTGTCTCAACATTCAAATCTCTCAGTTTTTACAAGAACGTCTCTAGATGGA
  AACTTGCAAAAGCAGGGCAAAATAATCAGATTCTCCGAATCTCAGTGGAGCCACGCAAAAATTGATCTC
  ATTGCAGAAGCGGGAGAATCTACTCTACCTTTTCAGTTAATTTTGGAAGCTACTGTTTTGTCGTCAAAT
  GCTACCGTTGCTCTAGATGACATCAGTGTGTCCCAGGAATGTGAAATTTCCTATAAATCACTACCAAGG
  ACCAGTACACAAAGCAAGTTTTCCAAGTGTGACTTTGAAGCAAACAGCTGTGATTGGTTTGAAGCAATT
  AGTGGTGACCATTTTGACTGGATACGGAGCTCTCAGAGTGAACTTTCTGCTGATTTTGAGCACCAGGCT
  CCACCTCGGGATCATAGTCTCAACGCATCTCAAGGGCATTTTATGTTCATTCTGAAGAAAAGCAGCAGC
  TTGTGGCAAGTTGCTAAGCTTCAGAGCCCAACTTTCAGCCAGACAGGACCTGGATGCATACTTTCCTTC
  TGGTTCTATAACTATGGCCTGTCAGTGGGAGCAGCTGAGCTGCAGCTACATATGGAAAATTCTCATGAC
  TCAACAGTGATTTGGAGAGTATTATACAATCAGGGCAAACAATGGTTGGAGGCAACCATTCAGCTAGGG
  CGCCTTTCGCAGCCCTTCCATTTGTCACTAGATAAAGTCAGTCTGGGCATTTATGATGGGGTCTCAGCT
  ATTGATGACATCCGATTTGAAAATTGTACTCTCCCTCTTCCTGCTGAGAGCTGTGAAGGGCTGGATCAT
  TTCTGGTGTCGCCACACCAGGGCTTGCATAGAAAAGCTTCGGTTATGTGATCTGGTGGATGACTGTGGT
  GATCGTACTGATGAAGTCAACTGTGCACCTGAGCTGCAGTGTAACTTTGAAACTGGAATCTGTAACTGG
  GAACAAGATGCAAAAGATGACTTTGATTGGACCAGGAGCCAGGGTCCAACTCCAACACTTAACACAGGG
  CCAATGAAAGATAACACTCTGGGCACAGCTAAAGGACACTATCTCTACATAGAATCTTCAGAGCCACAG
  GCTTTTCAAGACAGTGCTGCCTTACTCAGCCCAATCCTTAATGCCACTGATACAAAAGGCTGCACCTTC
  CGCTTCTATTACCACATGTTTGGAAAGCGCATTTATAGGTTGGCAATCTACCAACGAATCTGGAGTGAC
  TCAAGGGGACAGCTGCTGTGGCAGATATTTGGGAATCAAGGCAACAGATGGATTAGGAAACACCTCAAC
  ATTTCCAGCAGGCAGCCCTTTCAGATATTGGTGGAGGCTTCAGTGGGAGATGGCTTCACTGGAGATATT
  GCGATTGATGATCTGTCATTTATGGACTGCACCCTCTACCCTGGTAATTTGCCAGCAGACCTCCCAACT
  CCACCAGAAACGTCAGTTCCTGTAACATTACCTCCACACAACTGCACAGACAATGAATTTATCTGCAGG
  TCTGATGGTCACTGCATTGAAAAAATGCAGAAATGTGATTTTAAATATGACTGCCCTGACAAATCAGAT
  GAAGCATCCTGTGTTATGGAAGTTTGCAGCTTTGAGAAAAGAAGCCTGTGTAAATGGTATCAACCAATC
  CCAGTACATTTGCTTCAAGATTCAAACACATTCAGGTGGGGGCTTGGGAACGGGATCAGCATTCATCAT
  GGGGAAGAAAACCACAGGCCATCAGTGGATCATACACAAAATACCACTGATGGCTGGTACCTGTATGCT
  GACAGTTCTAATGGGAAATTTGGTGACACGGCTGACATTCTCACTCCTATCATTTCACTCACGGGACCA
  AAATGTACCTTGGTGTTCTGGACACATATGAATGGGGCCACCGTTGGTTCTCTCCAGGTGCTCATCAAG
  AAAGATAACGTTACTTCTAAATTGTGGGCTCAAACTGGACAGCAAGGTGCACAGTGGAAGAGAGCAGAA
  GTGTTTTTAGGCATTCGTTCACATACACAGATTGTCTTCAGAGCCAAACGTGGTATCAGTTACATAGGA
  GATGTAGCAGTGGATGATATTTCCTTCCAAGATTGCTCCCCTTTGCTTAGCCCAGAGAGAAAGTGTACT
  GATCATGAATTCATGTGTGCTAATAAGCACTGCATTGCCAAAGACAAGCTGTGTGATTTTGTGAATGAT
  TGTGCTGATAATTCAGATGAGACTACTTTCATTTGCCGTACCTCCAGTGGGCGCTGTGATTTCGAATTT
  GATCTTTGTTCCTGGAAGCAGGAGAAAGATGAGGACTTTGACTGGAACCTGAAAGCTAGCAGCATCCCT
  GCAGCAGGCACAGAGCCAGCAGCAGATCACACTTTGGGAAATTCATCTGGTCATTACATCTTTATAAAG
  AGTTTGTTTCCTCAGCAGCCCATGAGAGCTGCCAGAATTTCAAGTCCAGTTATAAGTAAGAGAAGCAAA
  AACTGCAAGATTATTTTTCATTATCACATGTATGGAAATGGCATTGGGGCACTCACCTTAATGCAGGTG
  TCAGTCACAAACCAAACGAAGGTTCTACTTAACCTCACTGTAGAACAAGGCAATTTCTGGCGGAGAGAA
  GAACTGTCACTGTTTGGTGATGAAGACTTCCAACTCAAATTTGAAGGTAGAGTTGGGAAAGGTCAGCGT
  GGAGACATTGCACTTGATGACATTGTGCTTACAGAAAATTGTCTATCACTCCATGATTCCGTGCAAGAA
  GAACTGGCAGTGCCTCTTCCAACAGGTTTCTGCCCACTTGGCTATAGGGAATGTCATAATGGAAAATGC
  TATAGGCTGGAACAAAGCTGTAACTTCGTAGATAACTGTGGAGATAATACTGATGAAAATGAGTGTGGT
  AGCTCCTGTACTTTTGAAAAAGGCTGGTGTGGCTGGCAAAACTCCCAGGCTGACAACTTTGATTGGGTT
  TTAGGGGTTGGCTCTCATCAAAGCTTAAGACCTCCCAAAGACCACACACTTGGAAATGAAAATGGGCAC
  TTCATGTATCTGGAAGCTACTGCAGTGGGCCTTCGGGGTGACAAAGCACACTTCAGGAGTACCATGTGG
  CGAGAATCCAGTGCAGCCTGCACCATGAGCTTCTGGTATTTCGTATCTGCAAAGGCCACAGGATCCATT
  CAGATTCTCATCAAGACAGAGAAAGGACTATCAAAAGTATGGCAAGAAAGTAAGCAGAACCCTGGTAAT
  CATTGGCAAAAGGCTGACATCCTGCTAGGAAAGTTAAGGAATTTTGAAGTCATATTTCAAGGTATCAGA
  ACAAGGGACCTGGGAGGAGGAGCTGCAATTGATGATATTGAATTTAAAAACTGCACAACTGTGGGAGAG
  ATCTCTGAGCTTTGTCCGGAAATCACTGATTTTTTGTGCCGGGACAAGAAGTGCATTGCATCCCACCTT
  CTTTGTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGCTCACTGTGCACATTATACAAGCACA
  ACAGGAAGCTGCAATTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGACTCT
  GAGGATGACTTGGACTGGGCCATTGGCAGCAGAATTCCTGCCAAAGCATTAATTCCAGACTCTGATCAC
  ACGCCAGGTAGTGGTCAGCACTTCCTGTACGTCAACTCATCTGGCTCCAAGGAAGGATCCGTTGCCAGA
  ATTACTACTTCCAAATCCTTCCCAGCAAGCCTTGGAATGTGTACTGTTCGGTTCTGGTTCTACATGATT
  GATCCCAGGAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACATCCTGGTGTGG
  TCAGTGATTGGAAATAAAAGAACGGGATGGACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTT
  AAGGTGGCATTTGAAGCTGATTTGGATGGAAATGAGGACATCTTTATTGCTCTTGATGACATCTCTTTT
  ACCCCAGAGTGTGTGACTGGAGGTCCTGTCCCAGTGCAGCCATCACCCTGTGAAGCTGATCAGTTTTCT
  TGTATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGAAGACTGCATAGATGGA
  TCTGATGAAATGGATTGTCCTCTCAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCT
  ACAGACGAGTGTATACCTTCCCTCCTGCTATGCGATGGAGTGCCCGACTGCCACTTTAATGAAGATGAG
  CTCATCTGCTCCAACAAAAGCTGTTCTAATGGAGCTCTGGTGTGTGCCTCCTCCAACAGCTGTATCCCA
  GCCCACCAGCGCTGTGATGGTTTTGCCGACTGCATGGATTTCCAGCTTGATGAGTCCAGCTGCTCCGAA
  TGTCCATTAAATTACTGCAGAAATGGTGGGACTTGTGTAGTGGAGAAAAATGGTCCTATGTGTCGATGT
  AGACAAGGCTGGAAAGGAAATCGATGCCATATCAAGTTTAATCCTCCTGCTACAGACTTCACATACGCT
  CAGAATAATACATGGACTCTCCTGGGTATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTC
  TTGTGTTTTCTTGCAAACAGAAAGGTACCAATAAGGAAAACCGAGGGAAGTGGTAACTGTGCCTTTGTC
  AATCCAGTTTACGGGAACTGGAGCAACCCAGAGAAAACAGAGAGTTCTGTCTATTCCTTCTCAAACCCA
  TTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTCACATCATCTCAAA
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC
  
  Protein Sequence

  >Peptide sequence encoded by RG240236
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  MLFFLDRMLAFPMNETFCCLWIACVFNSTLAQQGTESFQCDNGVSLPPDSICDFTDQCGDSSDERHCLN
  YERCDFEDGLCHMTQDQSLQPSWTKRSGMIGLSPPFYDHNGDVSAHFLSLVSRVDSISSSLRSRVFLPT
  NDQHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQWERNVIKIQSSQRFQVVFEGQMA
  STYEQDEVIAIDDISFSSGCLPANDGILLCQEALNAERELCHPDTDLCRFDATDEELRLCQACGFEFDM
  CEWTSEASAGQISWMRTKAREIPAFESTPQQDQGGDDEGYYVWVGAKHGFTLNHLDSRAYLNSSVCHCL
  GKSCHLQFYYAMESSVLRVRLYNNKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSF
  IALDHLWVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFC
  GWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVAKLGSPVLTKLLTASTPCQ
  VQFWYHLSQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIAEAGESTLPFQLILEATVLSSN
  ATVALDDISVSQECEISYKSLPRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQA
  PPRDHSLNASQGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHD
  STVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDH
  FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPTPTLNTG
  PMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSD
  SRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPT
  PPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPI
  PVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGP
  KCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIG
  DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF
  DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSK
  NCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQR
  GDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECG
  SSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENGHFMYLEATAVGLRGDKAHFRSTMW
  RESSAACTMSFWYFVSAKATGSIQILIKTEKGLSKVWQESKQNPGNHWQKADILLGKLRNFEVIFQGIR
  TRDLGGGAAIDDIEFKNCTTVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTST
  TGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVAR
  ITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPF
  KVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDG
  SDEMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIP
  AHQRCDGFADCMDFQLDESSCSECPLNYCRNGGTCVVEKNGPMCRCRQGWKGNRCHIKFNPPATDFTYA
  QNNTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTESSVYSFSNP
  LYGTTSGSLETLSHHLK
  TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV
  MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED
  SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA
  FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV
  
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001142308
• ORF Size: 6468 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_001142308.3
• RefSeq Size: 6880 bp
• RefSeq ORF: 6471 bp
• Locus ID: 340895
• Cytogenetics: 10p12.31
• Protein Families: Druggable Genome
• MW: 241.5 kDa
• Gene Summary: This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]