DCAMKL2 (NM_152619) Human Untagged Clone

CAT#: SC100617

DCAMKL2 (untagged)-Human doublecortin and CaM kinase-like 2 (DCAMKL2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DCAMKL2
• Synonyms: DCK2, DCDC3, MGC45428, DKFZp761I032
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_152619 edited
  ATGGCCAGCACCAGGAGTATCGAGCTGGAGCACTTTGAGGAACGGGACAAAAGGCCGCGG
  CCGGGGTCGCGGAGAGGGGCCCCCAGCTCCTCCGGGGGCAGCAGCAGCTCGGGCCCCAAG
  GGGAACGGGCTCATCCCCAGTCCGGCGCACAGTGCCCACTGCAGCTTCTACCGCACGCGG
  ACCCTGCAGGCCCTCAGCTCGGAGAAGAAGGCCAAGAAGGCGCGCTTCTACCGGAACGGG
  GACCGCTACTTCAAGGGCCTGGTGTTTGCCATCTCCAGCGACCGCTTCCGGTCCTTCGAT
  GCGCTCCTCATAGAGCTCACCCGCTCCCTGTCGGACAACGTGAACCTGCCCCAGGGTGTC
  CGCACTATCTACACCATCGACGGCAGCCGGAAGGTCACCAGCCTGGACGAGCTGCTGGAA
  GGTGAGAGTTACGTGTGTGCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAAT
  ATTAATCCAAACTGGTCTGTGAACATCAAGGGTGGGACATCCCGAGCGCTGGCTGCTGCC
  TCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCAAACCCAAGTTAGTGACT
  GTGATTCGAAGTGGAGTGAAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACT
  GCTCATTCCTTTGAACAAGTCTTAACAGATATCACCGAAGCCATTAAACTAGACTCAGGA
  GTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTTGTCTGCAAGACTTTTTT
  GGTGATGACGATGTTTTTATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGAC
  TTTGTCCTGGATCATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCTCGATCCTCAGCT
  GTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCAGCAAATCACCAGCTTCA
  GTTAATGGAACTCCCAGCAGCCAACTTTCTACTCCTAAATCTACGAAATCCTCCAGTTCC
  TCTCCAACTAGTCCAGGAAGTTTCAGAGGATTAAAGATTTCTGCTCATGGCAGATCTTCT
  TCCAATGTAAACGGTGGACCTGAGCTTGACCGTTGCATAAGTCCTGAAGGTGTGAATGGA
  AACAGATGCTCTGAATCATCAACTCTTCTTGAGAAATACAAAATTGGAAAGGTCATTGGT
  GATGGCAATTTTGCAGTAGTCAAAGAGTGTATAGACAGGTCCACTGGAAAGGAGTTTGCC
  CTAAAGATTATAGACAAAGCCAAATGTTGTGGAAAGGAACACCTGATTGAGAATGAAGTG
  TCAATACTGCGCCGAGTGAAACATCCCAATATCATTATGCTGGTCGAGGAGATGGAAACA
  GCAACTGAGCTCTTTCTGGTGATGGAATTGGTCAAAGGTGGAGATCTCTTTGATGCAATT
  ACTTCGTCGACCAAGTACACTGAGAGAGATGGCAGTGCCATGGTGTACAACTTAGCCAAT
  GCCCTCAGGTATCTCCATGGCCTCAGCATCGTGCACAGAGACATCAAACCAGAGAATCTC
  TTGGTGTGTGAATATCCTGATGGAACCAAGTCTTTGAAACTGGGAGACTTTGGGCTTGCG
  ACTGTGGTAGAAGGCCCTTTATACACAGTCTGTGGCACACCCACTTATGTGGCTCCAGAA
  ATCATTGCTGAAACTGGCTATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTGATCACA
  TACATACTTCTCTGTGGATTCCCACCATTCCGAAGTGAGAACAATCTCCAGGAAGATCTC
  TTCGACCAGATCTTGGCTGGGAAGCTGGAGTTTCCGGCCCCCTACTGGGATAACATCACG
  GACTCTGCCAAGGAATTAATCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGGTGTACC
  GCGGGACAAATCCTGAGTCACCCCTGGGTGTCAGATGATGCCTCCCAGGAGAATAACATG
  CAAGCTGAGGTGACAGGTAAACTAAAACAGCACTTTAATAATGCGCTCCCCAAACAGAAC
  AGCACTACCACCGGGGTCTCCGTCATCATGTTTGATTTGACAGTTTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152619 unedited
  ATTCGCACGAGGGCGCGTTAAGGGCCCTCGCAGTCAGACGTCCCTGCACCGGCGCTCGCA
  CCCTTAGTCGGCCCGGAACGTCTTTTTGCGGACGCCCTCGGAGCAGCCGCGATGGCCAGC
  ACCAGGAGTATCGAGCTGGAGCACTTTGAGGAACGGGACAAAAGGCCGCGGCCGGGGTCG
  CGGAGAGGGGCCCCCAGCTCCTCCGGGGGCAGCAGCAGCTCGGGCCCCAAGGGGAACGGG
  CTCATCCCCAGTCCGGCGCACAGTGCCCACTGCAGCTTCTACCGCACGCGGACCCTGCAG
  GCCCTCAGCTCGGAGAAGAAGGCCAAGAAGGCGCGCTTCTACCGGAACGGGGACCGCTAC
  TTCAAGGGCCTGGTGTTTGCCATCTCCAGCGACCGCTTCCGGTCCTTCGATGCGCTCCTC
  ATAGAGCTCACCCGCTCCCTGTCGGACAACGTGAACCTGCCCCAGGGTGTCCGCACTATC
  TACACCATCGACGGCAGCCGGAAGGTCACCAGCCTGGACGAGCTGCTGGAAGGTGAGAGT
  TACGTGTGTGCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCA
  AACTGGTCTGTGAACATCAAAGGTGGGACATCCCGAGCGCTGGCTGCTGCCTCCTCTGTG
  AAAAAGTGAGTAAAAGAAAGTAAAGATTTCATCAAACCCCAGTTAGTGACTGTGATTCGA
  AGTGGAGTGAAGCCTAAAAAGCCGTGCGGATCCCTCTGAATAAAAGACTGCTCATTCCTT
  TGAACAAAGTCTACAGATATCACCGAAACCTTTAACTAAACTCAGGAGTCGCCAAGAGCT
  CTGCACCCTGAAGGAAAGCAGGTACCTGTCTGCAAGACTTTTTTGAGAAGACGATGTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_152619 unedited
  NAAAAATACTTGTTTCGNGAGGGCAAAGATTTATTGCCTAGGTTGGGGNACACTTGNTAA
  AAGGCAAAATCTAACAATGAGAACGAACTATAGGGCTCGCCAGTTTAGAAGATGAGCAGG
  TAAAACAAATACACGGATTATGTACAATTATTAAAAAGAGCAGGGTGGTGGACAAAAAGG
  AAAAACTGCCAGCAGCCTTCCAGAAGGTTCACAGAGTATATCCAGGGAGCACCTTCCCGC
  CCAGTCCTGGCTGCCTCGGGCATGCCTCCTCCTGTGGTTACCTGCCCTGCTCCAGATGAA
  ATGCAGATGAGGAAGCAGCTACCGGGGCTCAGGAGCAGAGCTCATTCTGCTCGGCAAGTC
  GCTGGCTTGCAGGGAAGCAGCCGCTGGGTGCCGCATGCGCCAAGCCTCTCATTAAAAAGC
  CCAGAGGGCAAGTTCACGGGCATTTCCTAACACACGTGTGGGAAGAGCTGGGGGAAACCC
  ACACCGCCCAGGGAAGAAGTGGCTTCTTCCATCGTCTGTGTATGAATGAATACTGAGCAT
  TGTCTCTGGGGAGCCTGGTGCCCCAAGCCGAATGGCTGAGCCCGCCGCCCTGGGCCTCTG
  AGCGCTTCTCAAAGCCTGCAATCCGTGTCCAATGACCAAATTGTCCTCTCAGGCGCTCAC
  TTCTTCTATTAGAAAGCCAGTCCTCTTAGCCCCCATATCACCTCTCACAGGACACCCACA
  AAAGGACAAATGCAATTCTAAGTCCTTCGTCAAAAAAAAGGAGAGAGAGAGAAAAGAAAA
  GAAAGGGAATGTTCTGGATTCTACTTTAATAAGGAAAAGGCCTTGGTTTCATCCAAAGTG
  TTTCCAAAGTGTTTTTATAAAAATGCCATCGATGGCTGGATAAAGTTGCCCATTCTCCTG
  GTGAAGCCGTAAAAGGCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_152619
• ORF Size: 2088 bp
• Insert Size: 4700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_152619.1, NP_689832.1
• RefSeq Size: 3626
• RefSeq ORF: 2088
• Locus ID: 166614
• Domains: pkinase, TyrKc, S_TKc, DCX
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]