ENSA (AF067170) Human Untagged Clone
CAT#: SC102099
(untagged)-Human alpha endosulfine mRNA, complete cds
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Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | ENSA |
Synonyms | ARPP-19e |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC102099 sequence for AF067170 edited (data generated by NextGen Sequencing)
ATGTCCCAGAAACAAGAAGAAGAGAACCCTGCGGAGGAGACCGGCGAGGAGAAGCAGGAC ACGCAGGAGAAAGAAGGTATTCTGCCTGAGAGAGCTGAAGAGGCAAAGCTAAAGGCCAAA TACCCAAGCCTAGGACAAAAGCCTGGAGGCTCCGACTTCCTCATGAAGAGACTCCAGAAA GGGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAG CAGCTGCCAAGTGCAGGACCAGACAAGAACCTGGTGACTGGTGATCACATCCCCACCCCA CAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGGTAA Clone variation with respect to AF067170.1 279 c=>t >OriGene 5' read for AF067170 unedited
AATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCAGCAGCGCAGGTTGTCCC CGTTTCCCCTCCCCCTTCCCTTCTCCGGTTGCCTTCCCGGGCCCCTTACACTCCACAGTC CCGGTCCCGCCATGTCCCAGAAACAAGAAGAAGAGAACCCTGCGCTGGAGACCGGCGAGG AGAAGCAGGACACGCAGGAGAAAGAAGGTATTCTGCCTGAGAGAGCTGAAGAGGCAAAGC TAAAGGCCAAATACCCAAGCCTAGGACAAAAGCCTGGAGGCTCCGACTTCCTCATGAAGA GACTCCAGAAAGGGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGA TGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGAACCTGGTGACTGGTGATCACA TCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGG GGTAACCTGAGCCCCCCTCTCCTCCCCTTCCTCAACCACTGGACGTTTATATATTATAGG CAGGGATGAAATGGGCACCTAGTCAGATCTTCTCAGCTTGCTAGCCAGAAATGACTGTGA TTCTGCTGGGGGCTGCTGAGAAGGTAATGTANGTTGAAAAGGGGCTCTAAGTTTATTTAT TTCGTTAGATTGACACTTCCACACACTCCCTGTAGTCCAGGTAGGGCCCANAAATAGGAA AGGCTANGATTGGGATATGCTGCANATGCTTTTTTTGTGTGAGAAACTGGAGAGATGTGA TTTCTCCTTTTGGGAGAGATGTCCCANNATTGATTANGCTGAGCCTTGGGAATAGTTTGG CAGGTTAACATNCCAGGCTACCTAACGTANNTGGAAAGTANNATGATGAGACAATGTTCT TGCTCTTAGAGGTCTGTCCTTAGCTGTATTGCTCAT >OriGene 3' read for AF067170 unedited
NGGTACGACTATGNNACCGCGGCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTTTTT TTTTTATTTTTTTTTTTTTTTTTGAAAAAAACGTACAAAATTATATATATATTTATATAT ATAATAACATGACATATCTATGTACAACATGGCTGGGACAGTTGAAGAAACTATACAATG GTGTTCAGCATTTTCCCCTTCCCAGATGGACTTTAAGGATGACAGCATGAGGAAATGGAG CAAGAAACACAAAAATTATATACAATTACAAGTGACAGTCAAGGAGTTTGGGGACCAGGG AGTCCAGGGATCCTGCTCTCTCCATTCCTTCCTCACCAACTTTCTCCTATCCAATTTGAA TGACAGCCTGAACACTGAATGGCCAGTCAGGAGAAAGGCATATACACACCTCATCCCCCC ACATGCACATCAGCAAGTCTATCAGTCATTCTCATTGGGCCAAATGTTTGGCATATCAAA ATTTGTGATGTGAGAGGGCAAGAGGATTACAGAATCTTGCTCTCTTGAGCATTAGTTCTC ACCCTGGTCCTCTCTGTCATAACTAGCAAGTTGCGTTCAATAAAATTCTAGCCAAGCTGG TGGTAACTAGATTGAAGATGCTGGTCACCTGCAACCCCTTTCCTCCACCTGTTCATGAGT CAGCATGGCTACCTCTCCTCATGATAAAAGAGCTGGGTTGCTGAATTCTGGGGATGCAGA GATTTTTTAGTCTTTCTTCTCTTCCTCCCTAACCACTTTCCCCAGCTTCCTCCAGGTGAA TAATCTCCTAAGACCTGTTTCTCCACCCTGCAGAATACTTACCCCCAGGGGCTAGCTCAG TTAACCCCTCTCCTCTTTCCTAACAATATACCTGGCATCAGACTGCATTTGGAACAAGGG TCCAAACATGTGCCTGACTG |
Restriction Sites | NotI-NotI |
ACCN | AF067170 |
Insert Size | 2750 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | AF067170.1, AAD32454.1 |
RefSeq Size | 2520 bp |
RefSeq ORF | 2520 bp |
Locus ID | 2029 |
Cytogenetics | 1q21.3 |
Domains | endosulfine |
Protein Families | Druggable Genome |
Gene Summary | 'The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]' |
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