Estrogen Related Receptor gamma (ESRRG) (NM_001438) Human Untagged Clone

CAT#: SC102184

ESRRG (untagged)-Human estrogen-related receptor gamma (ESRRG), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ESRRG
• Synonyms: ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC102184 sequence for NM_001438 edited (data generated by NextGen Sequencing)
  ATGGATTCGGTAGAACTTTGCCTTCCTGAATCTTTTTCCCTGCACTACGAGGAAGAGCTT
  CCCTGCAGAATGTCAAACAAAGATCGACACATTGATTCCAGCTGTTCGTCCTTCATCAAG
  ACGGAACCTTCCAGCCCAGCCTCCCTGACGGACAGCGTCAACCACCACAGCCCTGGTGGC
  TCTTCAGACGCCAGTGGGAGCTACAGTTCAACCATGAATGGCCATCAGAACGGACTTGAC
  TCGCCACCTCTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGGCCTGTCAGGAAACTG
  TATGATGACTGCTCCAGCACCATTGTTGAAGATCCCCAGACCAAGTGTGAATACATGCTC
  AACTCGATGCCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACTAT
  GGGGTAGCATCATGTGAAGCCTGCAAGGCATTCTTCAAGAGGACAATTCAAGGCAATATA
  GAATACAGCTGCCCTGCCACGAATGAATGTGAAATCACAAAGCGCAGACGTAAATCCTGC
  CAGGCTTGCCGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTT
  GACAGAGTACGTGGAGGTCGGCAGAAGTACAAGCGCAGGATAGATGCGGAGAACAGCCCA
  TACCTGAACCCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCACAT
  TTGTTGGTGGCTGAACCGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCCGACAGT
  GACATCAAAGCCCTCACTACACTGTGTGACTTGGCCGACCGAGAGTTGGTGGTTATCATT
  GGATGGGCGAAGCATATTCCAGGCTTCTCCACGCTGTCCCTGGCGGACCAGATGAGCCTT
  CTGCAGAGTGCTTGGATGGAAATTTTGATCCTTGGTGTCGTATACCGGTCTCTTTCATTT
  GAGGATGAACTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAGCA
  GGCCTTCTTGATCTAAATAATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAG
  CTGGAAAAAGAAGAATTTGTCACCCTCAAAGCTATAGCTCTTGCTAATTCAGACTCCATG
  CACATAGAAGATGTTGAAGCCGTTCAGAAGCTTCAGGATGTCTTACATGAAGCGCTGCAG
  GATTATGAAGCTGGCCAGCACATGGAAGACCCTCGTCGAGCTGGCAAGATGCTGATGACA
  CTGCCACTCCTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTTCTACAACATCAAACTA
  GAAGGCAAAGTCCCAATGCACAAACTTTTTTTGGAAATGTTGGAGGCCAAGGTCTGA
  
  Clone variation with respect to NM_001438.3
  62 t=>c;957 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001438 unedited
  TCACAATAGGNATACGATTACTATAGGCGGCCGCGAATTCGGCACGAGGCTTGATTAGGA
  GAGTGTGAGAGCTTTGGTCCCAACTGGCTGTGCCTATAGGCTTGTCACTAGGAGAACATT
  TGTGTTAATTGCACTGTGCTCTGTCAAGGAAACTTTGATTTATAGCTGGGGTGCACAAAT
  AATGGTTGCCGGTCGCACATGGATTCGGTAGAACTTTGCCTTCCTGAATCTTTTTCCCTG
  CACTACGAGGAAGACTTTCCCTGCAGAATGTCAAACAAAGATCGACACATTGATTCCAGC
  TGTTCGTCCTTCATCAAGACGGAACCTTCCAGCCCAGCCTCCCTGACGGACAGCGTCAAC
  CACCACAGCCCTGGTGGCTCTTCAGACGCCAGTGGGAGCTACAGTTCAACCATGAATGGC
  CATCAGAACGGACTTGACTCGCCACCTCTCTACCCTTCTGCTCCTATCCTGNGAGGTAGT
  GGGCCTGTCAGGAAACTGTATGATGACTGCTCCAGCACCATTGTTGAAGATCCCCAGACC
  AAGTGTGAATACATGCTCAACTCGATGCCCAAGAGACTGTGTTTAGTGTGTGGTGACATC
  GCTTTTGGGTACCACTATGGNGTAGCATCATGTGAAGCCTGCAAGCATTCTTCAAGAAGA
  CAATTCAAGGCATATGAATACAGCTGCCCTGCCACGAATGAATGTGAAATCACAAAACGC
  AGACGTAAAATCTGCCCAGCTTGCCGCTTCATGTAATGTTTAAAAGTGGCCATGCTGAAA
  GAAGGTGTGCGTCTTGACAGATAACTGGAGGTTCGCCAAAAGTACCAGCCCACGATATAT
  TGCGNAGAACACCCCTTACCTGACCCTCAGCTGGTTCACCCAGCCCAAAAGTCTTTTACA
  CGATTGGTTAACATTGTTTGTTGCCTGAACCGGAAAAAATCTATTCATGCCTGAACCTAT
  TGTCCCCGACAGGACATAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001438 unedited
  GGTACTCTAGGTACGCGGCCGCATTTTAGGATCGAGTTTTATTTCTTTTTTTTTAATTCT
  GGCATTTGCCTTATTGCCTCTTAAATGATACTGGCTCACAGCTCCTTCTGAGGCAAGGTC
  TGTGACTTTGCAAACAGGCAGTATCACATTCCTAACCACCATGGCAGCTAGAAATCATAT
  GGCAATTGTACCTCCCAAGTAGAGAGGTGCACTCCTGACTATTCTACGGATCTATATCTC
  ATGTGCAGTGCTTATATATGTGACTACTCAGAGTCACTGTAGGTGTAATCTCATCCTTTG
  TGTCAGTGAACATTTAGGTAAACTGGAGCTCATGTTAAGAAATTGATGTTTGGGACCAGA
  CTGGCACACAACATAAATTGCATCCGTGATAATATGCACCTTCCCTTCAACTATTGCTTG
  AGTAAGTTAAATTCCCATATTAATAAATGGCTGAAAAGTGGTAAAGCTGGTACAAAAAAA
  TCTCCATTTGTAAGAAGAAACAAAACATTTTTAAAAATCTTCCTTCAGGATTCATTTGTC
  CTTCATTATTGTTCGTAATTGTTCAAAGCCAGCACAAAATTGCAGTATTCTTATTTCTCT
  TTAGTATTGCATGAATGAATAAAGCTTANACTATTCCCTGAAAAAGTTACATAGTAGCTA
  AACTAACAAATACCTGGAAGACTTGAAAAAACAATTAAGGAATCAAATGGCTGTTACTGA
  TCTAGATGGAAAAGCAATGATAAGAAGCAGCCGATGCCACGTTGCCTTAGTTTGTCTAAT
  TAGAGGCTGCTTCCATGAAATCTAATACTGCACTCAGTCAATTTGTATATGTTGCACTGT
  ACTTTTAGGAACGTTGGGTTCTCTCTCTTTGGATTCCCTAAACATTGGGGACGGTATGGG
  TAACAAAAGGTTCACGGGCATCCCTATT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001438
• Insert Size: 3100 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001438.2, NP_001429.2
• RefSeq Size: 5253 bp
• RefSeq ORF: 1377 bp
• Locus ID: 2104
• Cytogenetics: 1q41
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Gene Summary: 'This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]'
  Transcript Variant: This variant (1) encodes isoform 1.