DUSP3 (AK055834) Human Untagged Clone

CAT#: SC104666

(untagged)-Human cDNA FLJ31272 fis, clone KIDNE2006248

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DUSP3
• Synonyms: VHR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for AK055834, the custom clone sequence may differ by one or more nucleotides
  
  
  CACAGAGGTCCCTCATGACCTCCCTTCCCCAACTCCCGAATCCTCTCTTGAGTGTGGACCTCAACACCTT
  GAGCCCTAGTAAAGGAACTATGCAAATGCAGGCCACTCTCCCCACCACGTCTGTGCCCCGCACTGTCCCC
  ACAGCCTTCCACACCCTGTGCATAGGCAGCCCTCTCACGTCTTGAGGTCCGAAGCTGGGGTGGGGGTGTC
  CGTCAGTTATTAGTGGATGGAGATTCCCACAGCAAGGCTGCATTTGAATGATTTCCTTAGGATGAATGGT
  CCCTACACAAAGAGGCCTTGTGGGCAAACCTGGAGAACCCCCCTAAATCCATAGAGTTTTCAAAATGTGA
  ATCTTTGGAAGCCTTGAGTTCAGAATCTGCTGCTCTGGAATATTTCCCTTCGATCTTATCTCAGTCACTT
  CGTTTTTGAGAAGAGTGATGCCTTGGGCATGCTTTTTTTTTTTTTCTTTTTTAGAAAACAGGGAGTTGAA
  GTCCAACCTATTTAAAAACCCCACCATTTGGAGAATTACAAGGGTTTTGTCCTGAATTGTAGTGTTGGCA
  AGCCCAAGCCACTCGTGCTAACTGCTTTTTGTCTCGGTTGCTATTCCAAGAACAGAAGGAGGAAGTTGGC
  CAATTACAGCGTGTGTGCATGGATGTGTGTGGGGGGCGTGCCTCTCAGAAACGCGGCCAGAAGACAAGCA
  GGGAAGTGAAAGGTCCCAGGCACACACCCTGCCCATTGCAGGTGGCTCTTACAGCTCTCTGGTGCCAGCA
  CGGGATCCCTGAAGTGACTCAGCCAGGCAGACATGAGACATGGCGGAGTGTCCAAATGGATCCTTTATTG
  GTGGTAGAGCAAAAAAACCCAAACACGATAAACCTTTCAAAAGACTTTCTAAGGATGATATTGGAATGCA
  CCAGCCCTCACATGTGTATGCACATTTGCCAGAATATAAGAGTTTTGTTTTAAATACAGTCTTGTTAGGA
  TTTTACGTTATTGTTATTATGGAAAGTGATTGTGATGCTATTTATCTTCAGGGTCACTCTGGGCAAAGAG
  AAGGTCCTCAGCCATGCCCCCAGCACCTTGCACATAGGTGTCTGATAAAAGTTTAAGAAATTAAACACTT
  TTTGAGCACCAAATATATATAGGGCATTGTTCTGGTGGGTGTGTCACGCTCCCAGAAGACTGAATTTATG
  GTAGGATCACTCGCAAGGCCTTGTGAAGGAGTCTTACCTAAAACAAAAGAAATATCAGGGACTTTTGTTG
  ACTATTTACAACTCAGTTTTACATTTAAATTCAGGCAGTGTTAATATGCCAAGGTAGGGAATGTGCCTTT
  TTCAGAGTTGGCCAGGAGCTCCTGGCTGGGACACGGAGAGGCAGGTGTGGCGTAAGGCCTCACTCCCGGC
  TGTGAAGGTCTCTGATCACACAGAAGCAGCCCTGCCCAGCCTGGTCATTTGCTGTCCGCTTTTCTCTGTG
  ACCACAGCAGCCCTGAACAACCAGTATGTGTCTTCTTCTCCAGATAGTGAAAAAGGTGTCCAGATAAACC
  CACCTAAGTGAAATGGCCATCCTCTAAACTGGGTACCTCACTGCACAGCTTCTAGGTAGCCTTCCAACTT
  AATCTAACTTGAGCCTCACAGTAACCCTGTAAAGTTAGTAGAGCTTGTTCTTGTATTGTGACCTTTTTTA
  AAAAAAAGGAACCGAGGTTCAGAATGATTAAGGGCCTGGCCCCCAGGGTTGTCCAGCTCCATAAGGTGGA
  GCTGGGCAAGATTTTGGGTTTGCTGCTCCCTGAAGCTGGATTCTTTCATACGATACTCTTTCTCAAGAAG
  GGGGCTCCCTGGGATCTCCAGGTGTACTGCACTTACCCTCAATCCAGCCCCGGAGAAGCAAGTGAAAAGG
  GTGGGTCCCTCATAGGCTAGAATGTGCAGCTCTTTCTCCAGGTGGGATGTAGCACCCCAAAGTAGAGCTT
  TCTGCTCTGCTCCTGGAAAAGGCTAGGGAGCTGGGGCTGGGGCTCCCCTCCCATGACCAGGCAGTGGTCA
  CCCCATGGGACAGGCACAGCTACTTACGCGAACACAGCAGGTTGGTGTGGCTGGCTAACTAGGACCTCTC
  GAAAGTCTCTGTGGGGGCATGAGGGAGAAAAGGCCATTGGGAGAATTACTGCCTTTACTTTGGGACTACT
  TTTATGCTGATAACTTGGGATTTCTTGATAGTCCTTCACCCCTGAAACCCCGTATTTACTTAACAAGATT
  TAGCTCTTAGTTCTTCAAGTAAAATTAAAGTCTCTTGTGTAAGAGCCAACACATGCCCAGCTGCGGATGG
  GAGCTGTTCCTGGACAGCCTTCTACTGCCTGGGAAGTGATGGAACAGGAACTCAGGGTGCCCTTACCCCC
  TCCCCAGACCTGTTCCCTTTCTTTGACTGACAGAGCACCATCCAGGCAAAATTAGAGCGCCAAATGGTTT
  TCTTCTCAATCTTAAAGCAGTATACCTTTCCACAGGCTCGTCTGTGTCCCTGCCACTCTGAGTTATCCAG
  AAACCACCACCTACAAATGAGGGGACTCATCTAGAAGACCTCTAAGGTCCCCTTTTGGCTCTGAGGGGTC
  TCTAATAATCCCCACTTGGAATTCAGCACCGCAAGGAAATTATGGGTATGTGAGCCATAATATGATGGCC
  AGCAGGTGGCGCTGCCTTCCACCCATGGTGATGGATGGTTTGGAAAGGGAATGTTGGTGCCTTTTGTGCC
  ACAAGTTAAGATGCTACTGTTTTAAAGG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for AK055834 unedited
  GCCAAAATTGTAAACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGTGGACCTCACA
  CCTTGAGCCCTAGTAAAGGAACTATGCAAATGCAGGNCCACTCTCCCCACCACGTCTGTG
  CCCCGCACTGTCCCCACAGCCTTCCACACCCTGTGCATAGGCAGCCCTCTCACGTCTTGA
  GGTCCGAAGCTGGGGTGGGGGTGTCCGTCAGTTATTAGTGGATGGAGATTCCCACAGCAA
  GGCTGCATTTGAATGATTTCCTTAGGATGAATGGTCCCTACACAAAGAGGCCTTGTGGGC
  AAACCTGGAGAACCCTCCTAAATCCATAGAGTTTTCAAAATGTGAATCTTTGGAAGCCTT
  GAGTTCAGAATCTGCTGCTCTGGAATATTTCCCTTCGATCTTATCTCAGTCACTTCGTTT
  TTGAGAAGAGTGATGCCTTGGGCATGCTTTTTTTTTTTTCTTTTTTAGAAAACAGGGAGT
  TGAAGTCCAACCTATTTAAAAACCCCACCATTTGGAGAATTACAAGGGTTTTGTCCTGAA
  TTGTAGTGTTGGCAAGCCCAAGCCACTCGTGCTAACTGCTTTTTGTCTCGGTTGCTATTC
  CAAGAACAGAAGGAGGAAGTTGGCCAATTACAGCGTGTGTGCATGGATGTGTGTGGGGGG
  CGTGCCTCTCAGAAACGCGGCCAGAAGACAAGCAGGGAAGTGAAAGGTCCCAGGCACACA
  CCCTGCCCATTGCAGGTGGCTCTTACAGCTCTCTGGTGCCCAGCACGGATCCCTGNAGTG
  ACTCAGCCAGNCAGACATGAGACATGGCGGNAGTGNCCAATGGATCCTTTATNGNNTGTA
  GAGCANAAAACCCCAACACGAAAACCTTNCAAAGAACTTCTAGGATGATATNGAATGCAC
  CAGCCTACATGTGTATGCCATTTGCCAGATATAGAANNTTGTTTNATACAGNNCTGTTAG
  ATTTACGTN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for AK055834 unedited
  TGATCGCTGTCCGCAATTANAGTTGAGTTTTTTTTTTTTTTTTTTTTCCTTTAAAACAGT
  TGCATCTTAACTTGTGGCACAAAAGGCACCAACATTCCCTTTCCAAACCATCCATCACCA
  TGGGTGGAAGGCAGCGCCACCTGCTGGCCATCATATTATGGCTCACATACCCATAATTTC
  CTTGCGGTGCTGAATTCCAAGTGGGGATTATTAGAGACCCCTCAGAGCCAAAAGGGGACC
  TTAGAGGTCTTCTAGATGAGTCCCCTCATTTGTAGGTGGTGGTTTCTGGATAACTCAGAG
  TGGCAGGGACACAGACGAGCCTGTGGAAAGGTATACTGCTTTAAGATTGAGAAGAAAACC
  ATTTGGCGCTCTAATTTTGCCTGGATGGTGCTCTGTCAGTCAAAGAAAGGGAACAGGTCT
  GGGGAGGGGGTAAGGGCACCCTGAGTTCCTGTTCCATCACTTCCCAGGCAGTAGAAGGCT
  GTCCAGGAACAGCTCCCATCCGCAGCTGGGCATGTGTTGGCTCTTCACAAGAGACTTTAT
  TTTACTTGAAGACTAAGAGCTAAATCTTGTTAGTAAATACGGGGTTTCAGGGGTGAAGGA
  CTATCAAGAAATCCCAAAGTATCAGCATAAAAGTAGTCCCCAAGTAAAAGCAGTAATTCT
  CCCAATGGCTTTTCTCCCTCATGCCCCCACAAAACTTTCAGAAGGCCTAGTTAGCCAGCC
  CCACCACCTGCTGGGTCCCGTAAGAGCTTGGCCTGGCCAAGGGGTGACACACTGCTGTCA
  TGGGAGGGAACCCCAACCCCAGTTCCTACCTTTCCAGAACAAGAAAAAAACCTTCTTTTG
  GGGGCTCTCCCCCCCGGGAAAAAATCGCATTTCTACCTTTAAGGCCCCCCCTTCT
  
• Restriction Sites: NotI-NotI
• ACCN: AK055834
• ORF Size: 2758 bp
• Insert Size: 2750
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: AK055834.1
• RefSeq Size: 2758
• RefSeq ORF: 2758
• Locus ID: 1845
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: MAPK signaling pathway
• Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]