Axin 2 (AXIN2) (BC006295) Human Untagged Clone

CAT#: SC106135

AXIN2 (untagged)-Homo sapiens, Similar to axin 2 (conductin, axil), clone MGC:10366 IMAGE:4053244, complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AXIN2
• Synonyms: AXIL; axin 2; conductin; DKFZp781B0869; MGC10366; MGC126582
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for BC006295, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAGTAGCGCTATGTTGGTGACTTGCCTCCCGGACCCCAGCAGCAGCTTCCGTGAGGATGCCCCGCGGC
  CCCCAGTGCCAGGGGAAGAAGGGGAGACCCCACCGTGTCAGCCAGGGGTGGGCAAGGGCCAGGTCACCAA
  ACCCATGCCTGTCTCTTCCAACACCAGGCGGAACGAAGATGGGTTGGGGGAGCCGGAGGGGCGGGCATCT
  CCGGATTCCCCTCTGACCCGGTGGACCAAGTCCTTACACTCCTTATTGGGCGATCAAGACGGTGCTTACC
  TGTTCCGAACTTTCCTGGAGAGGGAGAAATGCGTGGATACCTTAGACTTCTGGTTTGCCTGCAATGGATT
  CAGGCAGATGAACCTGAAGGATACCAAAACTTTACGAGTAGCCAATGACTTTTGTCATGACATTTTGTTC
  TACTTATACTGTAAATTATGCATTATAAAGAGTTCATTTAAGGAAAATTACTTGGTACAATAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC006295 unedited
  CAAATTTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGGGGAGGTCAGGG
  NAAGACAGAGGTGTTGACTGAGCTGGATTCTTGGTGGGGAGAGGAGGTTCAGATGAGCCC
  CTGCTGACTTGAGAGAGACAGAGAGACCACGCCGATTGCTGAGAGGAACTGGAAGAAGAA
  AAATTCCCAGACTCAGTGGGAAGAGCTCCCTCACCATGAGTAGCGCTATGTTGGTGACTT
  GCCTCCCGGACCCCAGCAGCAGCTTCCGTGAGGATGCCCCGCGGCCCCCAGTGCCAGGGG
  AAGAAGGGGAGACCCCACCGTGTCAGCCAGGGGTGGGCAAGGGCCAGGTCACCAAACCCA
  TGCCTGTCTCTTCCAACACCAGGCGGAACGAAGATGGGTTGGGGGAGCCGGAGGGGCGGG
  CATCTCCGGATTCCCCTCTGACCCGGTGGACCAAGTCCTTACACTCCTTATTGGGCGATC
  AAGACGGTGCTTACCTGTTCCGAACTTTCCTGGAGAGGGAGAAATGCGTGGATACCTTAG
  ACTTCTGGTTTGCCTGCAATGGATTCAGGCAGATGAACCTGAAGGATACCAAAACTTTAC
  GAGTAGCCAAAGCGATCTACANAAGGTACATTGAGAACAACAGCATTGTCTCCAAGCAGC
  TGAAGCCTGCCACCAAGACCTACATAAGAGATGGCATCAAGAAGCAGCAGATTGATTCCA
  TCATGTTTGACCANGCGCAGACCGAGATCCAGTCGGTGATGGGAGAAAATGCTACCAGAT
  GTTNNTGACTTCTGATATATACCTCGAATATGTNGAGAGTGGGGGAGGAAACACAGCTTA
  CATGNAGTATGGGGGACTCGGGAGCCTAANGGGTCGTGTGTGGCTATCTTCCCACCTTTG
  GATGAGAANAAGGATGGNACTTGTGCCGACTTCAGTGCAAACTTTCGCAACCGTGGTGGC
  TTGTCC
  
• Restriction Sites: NotI-NotI
• ACCN: BC006295
• ORF Size: 483 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC006295.2, AAH06295.1
• RefSeq Size: 1041
• RefSeq ORF: 483
• Locus ID: 8313
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Wnt signaling pathway
• Gene Summary: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]