NBR1 (NM_031862) Human Untagged Clone

CAT#: SC107091

NBR1 (untagged)-Human neighbor of BRCA1 gene 1 (NBR1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NBR1
• Synonyms: 1A1-3B; IAI3B; M17S2; MIG19
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107091 sequence for NM_031862 edited (data generated by NextGen Sequencing)
  ATGGAACCACAGGTTACTCTAAATGTGACTTTTAAAAATGAAATTCAAAGCTTTCTGGTT
  TCTGATCCAGAAAATACAACTTGGGCTGATATCGAAGCTATGGTAAAAGTTTCATTTGAT
  CTGAATACTATTCAAATAAAATACCTGGATGAGGAAAATGAAGAGGTATCCATCAACAGT
  CAAGGAGAATATGAAGAAGCGCTTAAGATGGCAGTTAAACAGGGAAACCAACTGCAGATG
  CAAGTCCACGAAGGGCACCATGTCGTTGATGAAGCCCCACCCCCAGTTGTAGGAGCAAAA
  CGACTAGCTGCCAGGGCAGGGAAGAAGCCACTTGCACATTACTCTTCACTGGTGAGAGTC
  TTGGGATCAGACATGAAGACCCCAGAGGATCCTGCAGTGCAGTCGTTTCCACTTGTTCCA
  TGTGACACAGACCAGCCTCAAGACAAGCCCCCAGACTGGTTCACAAGCTACCTGGAGACG
  TTCAGAGAACAAGTGGTTAACGAAACGGTTGAGAAGCTTGAACAGAAATTACATGAAAAG
  CTTGTCCTCCAGAACCCATCCTTGGGTTCTTGTCCCTCAGAAGTCTCAATGCCTACTTCA
  GAAGAAACATTGTTTTTGCCAGAAAACCAGTTCAGCTGGCATATTGCTTGCAACAACTGC
  CAAAGAAGGATTGTTGGTGTCCGCTACCAGTGTAGCCTATGCCCATCCTACAATATCTGT
  GAAGATTGTGAAGCAGGGCCATATGGCCATGACACTAACCACGTCCTGCTGAAGTTGCGG
  AGACCTGTTGTGGGCTCCTCTGAACCGTTCTGTCACTCAAAGTACTCTACTCCTCGTCTT
  CCTGCTGCTCTGGAACAAGTCAGGCTCCAGAAACAGGTTGATAAGAACTTTCTTAAAGCA
  GAAAAGCAAAGGTTGCGAGCTGAGAAGAAACAACGTAAAGCAGAGGTCAAGGAACTTAAA
  AAGCAGCTTAAACTCCATAGGAAAATTCACCTGTGGAATTCAATCCATGGACTCCAGAGC
  CCCAAGTCTCCTTTAGGCCGACCTGAGAGCTTGCTCCAGTCTAATACCCTGATGCTCCCT
  TTGCAGCCCTGTACCTCCGTTATGCCAATGCTCAGTGCAGCATTTGTGGATGAGAATTTG
  CCTGATGGGACTCACCTTCAGCCAGGAACCAAGTTTATCAAACACTGGAGGATGAAAAAT
  ACAGGAAATGTAAAGTGGAGTGCAGACACAAAGCTCAAGTTCATGTGGGGAAACCTGACT
  TTGGCTTCCACAGAAAAGAAGGATGTTTTGGTTCCCTGCCTCAAGGCCGGCCATGTGGGA
  GTTGTATCTGTGGAGTTCATTGCCCCAGCCTTGGAGGGAACGTATACTTCCCATTGGCGT
  CTTTCTCACAAAGGCCAGCAATTTGGGCCTCGGGTCTGGTGCAGTATCATAGTAGATCCT
  TTCCCCTCCGAAGAGAGCCCTGATAACATTGAAAAGGGCATGATCAGCTCAAGCAAAACT
  GATGATCTCACCTGCCAGCAAGAGGAAACTTTTCTTCTGGCTAAAGAAGAAAGACAGCTT
  GGTGAAGTGACTGAGCAGACAGAAGGGACAGCAGCCTGCATCCCACAGAAGGCAAAAAAT
  GTTGCCAGTGAGAGGGAGCTCTACATCCCATCTGTGGATCTTCTGACTGCCCAGGACCTG
  CTGTCCTTTGAGCTGTTGGATATAAACATTGTTCAAGAGTTGGAGAGAGTGCCCCACAAC
  ACCCCTGTGGATGTGACTCCCTGCATGTCTCCTCTGCCACATGACAGTCCTTTAATAGAG
  AAGCCAGGCTTGGGGCAGATAGAGGAAGAGAATGAAGGGGCAGGATTTAAAGCACTTCCT
  GATTCTATGGTGTCAGTAAAGAGGAAGGCTGAGAACATTGCTTCTGTGGAGGAAGCAGAA
  GAAGACCTGAGTGGGACCCAGTTTGTGTGTGAGACAGTAATCCGATCCCTTACCTTGGAT
  GCTGCCCCAGACCACAACCCTCCTTGCAGACAGAAGTCCTTGCAGATGACATTTGCCTTG
  CCTGAAGGACCACTTGGAAATGAGAAGGAGGAGATTATCCATATCGCTGAGGAAGAAGCT
  GTCATGGAGGAGGAGGAGGATGAGGAGGATGAGGAGGAGGAGGATGAGCTCAAAGATGAA
  GTTCAAAGTCAGTCCTCTGCTTCCTCAGAGGATTACATCATCATCCTGCCTGAGTGCTTT
  GATACCAGCCGCCCCCTGGGGGATTCTATGTACAGCTCTGCGCTCTCACAGCCAGGCCTG
  GAGCGAGGTGCTGAAGGCAAGCCTGGGGTTGAGGCTGGGCAGGAACCAGCTGAGGCTGGG
  GAAAGACTCCCTGGAGGGGAGAACCAGCCACAGGAGCACAGCATAAGTGACATCCTCACG
  ACCTCACAGACTCTGGAAACAGTGCCCCTAATCCCAGAGGTAGTGGAGCTTCCACCGTCA
  CTGCCCAGGAGCTCTCCTTGTGTACATCATCATGGTTCCCCAGGAGTGGATTTACCAGTT
  ACCATACCAGAAGTTTCTTCAGTCCCTGATCAGATCAGAGGAGAGCCCAGAGGCTCATCA
  GGACTTGTAAACAGCAGACAGAAGAGCTATGACCACTCAAGGCACCATCATGGGAGCAGC
  ATTGCTGGAGGACTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTCTGCATACAAGGCCCTG
  TTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTG
  ATGGCCCGTCTCTTTGAAATGGGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAG
  AAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAACAACGAC
  TGGTACAGCCAACGCTATTGA
  
  Clone variation with respect to NM_031862.2
  2768 a=>g
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_031862 unedited
  CAGTATATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCCCCACAG
  GATAGCGGCAGAGCCGGTAGCGGACGGTCCTTGCATTGGCCTCCGGCAGGCGCCCCCCGG
  GGGCGGGAAGCTGCCTCACAGCATGGAACCACAGGTTACTCTAAATGTGACTTTTAAAAA
  TGAAATTCAAAGCTTTCTGGTTTCTGATCCAGAAAATACAACTTGGGCTGATATCGAAGC
  TATGGTAAAAGTTTCATTTGATCTGAATACTATTCAAATAAAATACCTGGATGAGGAAAA
  TGAAGAGGTATCCATCAACAGTCAAGGAGAATATGAAGAAGCGCTTAAGATGGCAGTTAA
  ACAGGGAAACCAACTGCAGATGCAAGTCCACGAAGGGCACCATGTCGTTGATGAAGCCCC
  ACCCCCAGTTGTAGGAGCAAAACGACTAGCTGCCAGGGCAGGGAAGAAGCCACTTGCACA
  TTACTCTTCACTGGTGAGAGTCTTGGGATCAGACATGAAGACCCCAGAGGATCCTGCAGT
  GCAGTCGTTTCCACTTGTTCCATGTGACACAGACCAGCCTCAAGACAAGCCCCCAGACTG
  GTTCACAAGCTACCTGGAGACGTTCAGAGAACAAGTGGTTAACGAAACGGTTGAGAAGCT
  TGAACAGAAATTACATGANAAGCTTGTCCTCCAGAACCCATCCTNTGGTTCTTGTCCCTC
  AGAAGTCTCAATGCCTACTTCAGAAGAAACATTGNNTTTGCCAGAAACCAGTTCAGCTGG
  CATATTGCTTTTGCACACTGCCNAAGAANNGATTGTGGTGTCCGCTACCAGTGTAGCCTA
  TGTCCATCCCTACATATCTGTGAAGATTGTGAAAGCAGGCCATATGGCCATGACACTAAC
  CACGTTCTGCTGAAGTTGCGGAGACCTGTGTGGGCTCCTCTGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_031862 unedited
  TTGGACCGCGGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTGCAGTT
  TGAATCCTGGTTTATTTAAGTAGCATTCAGGAGTTATACTGTAAATAAACATCATTATGG
  CTAATGACTAATTAAAATCACCATTCATTACAAATACCAACCAGGTTAGATAATACTATT
  AACTATCTTTTCCCCTTCGGTCTGGGGTTCATATTCTTCCTTTTCTGGAAGTCATTTTCA
  TGGATAAAATATTTAGCATTTTTTGTTACCTCTTCCTTCACCAACTGTACTCAACACACT
  TCTGTAAACAGAGTGAGAACCTGGGTTCATGGACAAGCTCTTTTCCACTTATCTTCGGGT
  TAAACCAAAACTTTTTCAGCAACTTTGCCCCTGTCCAAGTTTTGCAGAACACCAGCTGCC
  TCTTCCTGTTCTAGGCATTCTAGGGCTAGATACCTGTGAACGGACTTCAAGCATTAAAGA
  AGTCATCAGCATTTCCTATACCTCACACACACTCATTTGCCCACCCTGAACTTCACTGAC
  ATTAATTTAGGAGCCTGCCTTTTGCCTTTCACATGTTTCTATTTCCCCCACTGTACTGTA
  AAATAAGATCTGCCCTGACATTAAGAAAAAAGGCAACTGTTAAATTTACTTTTCCCTTTA
  ATAACGGGATTTTTTCCTTTTCTATAAGATTAGCAAAATATTTCACAATACCTATATTTT
  TTCCCTTAAATAAAAATGTATGCAAAATTACTATAATAGACATTGCTCAATAGGGGCTGG
  TAGGTTTATCAGCACACTCTTTCTCCTTTCATTGAATGCAGAGATCCCTTTGAAGGTGGA
  ACTCTTGAATGCCCATGGAGTCTTTAGAAAGCAACGGTGCCATATTAAGATTGCAGGAAA
  ATACTTTCTCCTTGAAAAGAAGAGAACACATTTTANATGCTCTGGGGGTATTCATGCCAA
  TACTATGAGCTGAGGGGATACN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_031862
• Insert Size: 4110 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_031862.1, NP_114068.1
• RefSeq Size: 4654 bp
• RefSeq ORF: 2901 bp
• Locus ID: 4077
• Cytogenetics: 17q21.31
• Domains: PB1, ZnF_ZZ
• Protein Families: Druggable Genome
• Gene Summary: 'The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]'
  Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform a.