DRAM2 (NM_178454) Human Untagged Clone

CAT#: SC107170

DRAM2 (untagged)-Human DNA-damage regulated autophagy modulator 2 (DRAM2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DRAM2
• Synonyms: CORD21; PRO180; TMEM77; WWFQ154
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107170 sequence for NM_178454 edited (data generated by NextGen Sequencing)
  ATGTGGTGGTTTCAGCAAGGCCTCAGTTTCCTTCCTTCAGCCCTTGTAATTTGGACATCT
  GCTGCTTTCATATTTTCATACATTACTGCAGTAACACTCCACCATATAGACCCGGCTTTA
  CCTTATATCAGTGACACTGGTACAGTAGCTCCAGAAAAATGCTTATTTGGGGCAATGCTA
  AATATTGCGGCAGTTTTATGCATTGCTACCATTTATGTTCGTTATAAGCAAGTTCATGCT
  CTGAGTCCTGAAGAGAACGTTATCATCAAATTAAACAAGGCTGGCCTTGTACTTGGAATA
  CTGAGTTGTTTAGGACTTTCTATTGTGGCAAACTTCCAGAAAACAACCCTTTTTGCTGCA
  CATGTAAGTGGAGCTGTGCTTACCTTTGGTATGGGCTCATTATATATGTTTGTTCAGACC
  ATCCTTTCCTACCAAATGCAGCCCAAAATCCATGGCAAACAAGTCTTCTGGATCAGACTG
  TTGTTGGTTATCTGGTGTGGAGTAAGTGCACTTAGCATGCTGACTTGCTCATCAGTTTTG
  CACAGTGGCAATTTTGGGACTGATTTAGAACAGAAACTCCATTGGAACCCCGAGGACAAA
  GGTTATGTGCTTCACATGATCACTACTGCAGCAGAATGGTCTATGTCATTTTCCTTCTTT
  GGTTTTTTCCTGACTTACATTCGTGATTTTCAGAAAATTTCTTTACGGGTGGAAGCCAAT
  TTACATGGATTAACCCTCTATGACACTGCACCTTGCCCTATTAACAATGAACGAACACGG
  CTACTTTCCAGAGATATTTGA
  
  Clone variation with respect to NM_178454.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_178454 unedited
  CAGTCACCAATTGTAAACGACTCATATAGGCGGCCTGCGAATCGGCACGAGGTTTGAACG
  AGCAGCGCCGCAGGCGCGCTCCTCGGTGCCGTGAGCGCGCCCCGGGGCCGGCCGGTCTGC
  TCGGGAGCGCGCCCCGTGGCCCAGCCCTGTCTCCTTTTAGCATAGGGGCTTCGGCGCCAG
  CGGCCAGCGCTAGTCGGTCTGGTAAGGATTTACAAAAGGTGCAGGTATGAGCAGGTCTGA
  AGACTAACATTTTGTGAAGTTGTAAAACAGAAAACCTGTTAGAAATGTGGTGGTTTCAGC
  AAGGCCTCAGTTTCCTTCCTTCAGCCCTTGTAATTTGGACATCTGCTGCTTTCATATTTT
  CATACATTACTGCAGTAACACTCCACCATATAGACCCGGCTTTACCTTATATCAGTGACA
  CTGGTACAGTAGCTCCAGAAAAATGCTTATTTGGGGCAATGCTAAATATTGCGGCAGTTT
  TATGCATTGCTACCATTTATGTTCGTTATAAGCAAGTTCATGCTCTGAGTCCTGAAGAGA
  ACGTTATCATCAAATTAAACAAGGCTGGCCTTGTACTTGGAATACTGAGTTGTTTAGGAC
  TTTCTATTGTGGCAAACTTCCAGAAAACAACCCTTTTTGCTGCACATGTAAGTGGAGCTG
  TGCTTACCTTTGGTATGGGCTCATTATATANTGTTTGTTCAGACCATCCTTTCCTACCAA
  ATGCAGCCCAGAATCCATGGCAAACAAGTCTTCTGGATCAGACTGATGATGGTTATCTGG
  TGTGGNNAGTAGTGCACTTAGCATGCTGACTTGTTCATCAGTTTNGCACAGTGGCAATAT
  TGGGACTGATTTAGACAGAACTCATTGGACCCTAGACANGGGTATGTGCTCACATGAGCC
  TACTGCGCGAGGGCCTGNCATTTCTTCTTGGGTTTTCTGCTACATT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_178454 unedited
  NGGTCTATTATGNACGCGGCCGCTTTCTAGATCGGTTTTTTTTTTTTTTTTTTAGGTTAT
  GACTTTTATTAATCATATCTGCTGTTATTCCCAAACTTCTCATGTTACATGAATACTAAC
  CCTTGTTTTATATAAAATATGACTAAAGTAAATTTACCTACAGGTGCCTCTCTCCTTCAT
  TGGTGATTAAAATTTCACGCCAGAGACTAAACTTCATGAAACTACTGCAAGCATGTGTAT
  GATAGACCAATTAGCTTATTATCTGGCATTGTGGCCAGAAAAAAAAAAATCGTTACCTAC
  AAAATCTCTTGGGCAACACTTAAGCCATGGAAGAACCCACATGAATCCAGGTCTACTTTC
  CTTTACAGGTAGATTCCAGAACAACAACAAAAAATGTAAGACTACAAGAAATGATTTAAT
  ATGATAAAACTCCCATTTCAAAACCCAGTTCTAAAGGATTTACTGACTAATGCTGATTAT
  TTAGTCATGGAAAATGTCTCTCATAAAAGTGCTCCTAACAAAACATGATCTACAATAATT
  TATAAAATGTGAAGGGTTGGGATGTGCAGACTGATTGGTGCAGGTCAGGTTGTTTCTCTT
  AATAAGGTATAAAAAACTATGATATCATAGTCTTTTGACTTTATTTTCTGAGATAAAAAA
  GTATAGGCATAGGTGTTTTTAATAGTCTTCTTGATGATATCCTTTAGAANTATCTATCAA
  ATGGCTTCTTTCATGTTTCCTGATTATCAGCATTCATCAGTGTTACTGTCAGCCTTGATT
  AAGTGGGTGAAAATCTCAGAGAAGATAAGGCACTGCTGTGAAACCTTTCCCCATCCCTGA
  GAATCATAATCATTACAGAAATATTTTAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_178454
• ORF Size: 801 bp
• Insert Size: 1900
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_178454.2, NP_848549.2
• RefSeq Size: 1761
• RefSeq ORF: 801
• Locus ID: 128338
• Protein Families: Transmembrane
• Gene Summary: The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
  Transcript Variant: This variant (2), as well as variants 1 and 3-5, encodes isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.