HNRPM (HNRNPM) (NM_031203) Human Untagged Clone

CAT#: SC107969

HNRNPM (untagged)-Human heterogeneous nuclear ribonucleoprotein M (HNRNPM), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: HNRNPM
• Synonyms: CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107969 sequence for NM_031203 edited (data generated by NextGen Sequencing)
  ATGGCGGCAGGGGTCGAAGCGGCGGCGGAGGTGGCGGCGACGGAGATCAAAATGGAGGAA
  GAGAGCGGCGCGCCCGGCGTGCCGAGCGGCAACGGGGCTCCGGGCCCTAAGGGTGAAGGA
  GAACGACCTGCTCAGAATGAGAAGAGGAAGGAGAAAAACATAAAAAGAGGAGGCAATCGC
  TTTGAGCCATATGCCAATCCAACTAAAAGATACAGAGCCTTCATTACAAACATACCTTTT
  GATGTGAAATGGCAGTCACTTAAAGACCTGGTTAAAGAAAAAGTTGGTGAGGTAACATAC
  GTGGAGCTCTTAATGGACGCTGAAGGAAAGTCAAGGGGATGTGCTGTTGTTGAATTCAAG
  ATGGAAGAGAGCATGAAAAAAGCTGCGGAAGTCCTAAACAAGCATAGTCTGAGCGGAAGA
  CCACTGAAAGTCAAAGAAGATCCTGATGGTGAACATGCCAGGAGAGCAATGCAAAAGGCT
  GGAAGACTTGGAAGCACAGTATTTGTAGCAAATCTGGATTATAAAGTTGGCTGGAAGAAA
  CTGAAGGAAGTATTTAGTATGGCTGGTGTGGTGGTCCGAGCAGACATTCTTGAAGATAAA
  GATGGAAAAAGTCGTGGAATAGGCACTGTTACTTTTGAACAGTCCATTGAAGCTGTGCAA
  GCTATATCTATGTTCAATGGCCAGCTGCTATTTGATAGACCAATGCACGTCAAGATGGAT
  GAGAGGGCCTTACCAAAAGGAGATTTCTTCCCTCCTGAGCGTCCACAACAACTTCCCCAT
  GGCCTTGGTGGTATTGGCATGGGGTTAGGACCAGGAGGGCAACCCATTGATGCCAATCAC
  CTGAATAAAGGCATCGGAATGGGAAACATAGGTCCCGCAGGAATGGGAATGGAAGGCATA
  GGATTTGGAATAAATAAAATGGGAGGAATGGAGGGGCCCTTTGGTGGTGGTATGGAAAAC
  ATGGGTCGATTTGGATCTGGGATGAACATGGGCAGGATAAATGAAATCCTAAGTAATGCA
  CTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCT
  GGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATG
  GGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTG
  GTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCG
  CTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATT
  GGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCT
  CCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGC
  CCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCT
  GGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGC
  GCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATG
  GGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCCGCCATGGGCCCGGCC
  CTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTT
  GACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGT
  GGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAAT
  CTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTG
  CTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGTGTGGTTAAGTTC
  GAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGC
  CGAGAGATTGACGTTCGAATTGATAGAAACGCTTAA
  
  Clone variation with respect to NM_031203.3
  1665 t=>c;1968 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_031203 unedited
  TTCACATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGAATGGCGGCAGG
  GGTCGAAGCGGCGGCGGAGGTGGCGGCGACGGAGATCAAAATGGAGGAAGAGAGCGGCGC
  GCCCGGCGTGCCGAGCGGCAACGGGGCTCCGGGCCCTAAGGGTGAAGGAGAACGACCTGC
  TCAGAATGAGAAGAGGAAGGAGAAAAACATAAAAAGAGGAGGCAATCGCTTTGAGCCATA
  TGCCAATCCAACTAAAAGATACAGAGCCTTCATTACAAACATACCTTTTGATGTGAAATG
  GCAGTCACTTAAAGACCTGGTTAAAGAAAAAGTTGGTGAGGTAACATACGTGGAGCTCTT
  AATGGACGCTGAAGGAAAGTCAAGGGGATGTGCTGTTGTTGAATTCAAGATGGAAGAGAG
  CATGAAAAAAGCTGCGGAAGTCCTAAACAAGCATAGTCTGAGCGGAAGACCACTGAAAGT
  CAAAGAAGATCCTGATGGTGAACATGCCAGGAGAGCAATGCAAAAGGCTGGAAGACTTGG
  AAGCACAGTATTTGTAGCANATCTGGATTATANAGTTGGCTGGNAGAAACTGANNNGAGT
  ATTTAGTATGGCTGGTGTGGTGGTCCGAGCAGACATTCTTNGAGATAAAGATGGGAAAAG
  TCGNTGGATANGCACTGGTACTTNTTGACAGTCCCATTGAGCTGTGNCAGCTATATCTAT
  GTTCAATGGCCAGCTGCTATTTGATAGACCCATGCACCGTCAGATGGATTGAGAGGCCNT
  ACCAAAAAGAGAATTTTCTTCCTNCTGAGCGTCCACANCAACCTCCCCATGGGCCTNGTT
  GTATTGGCCATGGGGTTAGGCCCAGAAGGCACCCCATTGATGCCATCACCTGAATAAAGC
  ATCCGGAATGGGAACTAAGGTCCGCCGGGATGGGAATGGAAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_031203 unedited
  TCTGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTCAGGAACCG
  GTATTTATTATCAAAGTCATATTCGATGTCAACAAGATGCCACAACTACAAAAAAAATTG
  CGCACATTGCAATCTCAATGCAAACAGTCAAATGGAACCCCAGTCATTAAAAAAGTAATT
  CAAATTACCCCAAAAAGCAACTGAATTTTTTAAACATCTTTATACATCCAGCCAACAAAT
  TAAAATGGTTAACAAGAAAAAATACAAATTCAGAGGTCTCGTATCGATGTTTAAAAAAGG
  CAACTGCTTAAGCGTTTCTATCAATTCGAACGTCAATCTCTCGGCCACTCAGCTTCATGC
  CATTCATCATCCGGCAGGCTCTCTCGGCCACCTCTGGCGACTCGAACTTAACCACACCAC
  ACCCCTTGGACTTCCCATTCTCCATCTTGATGTCGGCGTACAGCACGTGGCCGCACTCGT
  TGAATTTGTCCTTTAGCATCTTCCATGTGAAATCGAATGGCAGATTTCTCACAAATATCT
  GGCAGGCCTTCCTGGCCACCCCAGGAGCATGGCCTCCAGCTCCACCAAAGGAACCTGCGA
  AGCTTCCTCCGAAGTTGCCACGCTCCATCTCGATGGCACGGTCAAAGCTGGCACCGCCAC
  CGCCACCCATGGCCAGGCCCATGCGCTCAATGCCAGCGCCCAGGGCCGGGCCCATGGCGG
  GGCCCATGCGCTCGAGGCTGTTGGCACCCATGCGCTNCAGGCCCATGCGCTCGAGGCTTG
  TGGCGCCCATGCGCTCCAGGCCCATCCGCTCCAGATTTGTGGCGCCCATGCGCTNCAGGC
  CGNTGGCCATGCGATCCATCACGGGGCCNATGCGCNTCAGCCAGCNCCATTACTGNGGGC
  ACATGCGCTCATGCTNCAGCCATGCGCTCGATGCAGGGCCATGCGCTCCACGCAGAGCCA
  TGCGCTCATGGTCTGCCCAACNGTCGATGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_031203
• Insert Size: 2380 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_031203.1, NP_112480.1
• RefSeq Size: 2586 bp
• RefSeq ORF: 2076 bp
• Locus ID: 4670
• Cytogenetics: 19p13.2
• Domains: RRM
• Protein Families: Druggable Genome
• Protein Pathways: Spliceosome
• Gene Summary: 'This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]'
  Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.