C9orf72 (NM_145005) Human Untagged Clone
CAT#: SC108239
C9orf72 (untagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1
"NM_145005" in other vectors (6)
Product Images
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | C9orf72 |
Synonyms | ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1 |
Vector | pCMV6-XL4 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC111893 sequence for NM_018325 edited
(data generated by NextGen Sequencing) ATGTCGACTCTTTGCCCACCGCCATCTCCAGCTGTTGCCAAGACAGAGATTGCTTTAAGTGGCAAATCAC CTTTATTAGCAGCTACTTTTGCTTACTGGGACAATATTCTTGGTCCTAGAGTAAGGCACATTTGGGCTCC AAAGACAGAACAGGTACTTCTCAGTGATGGAGAAATAACTTTTCTTGCCAACCACACTCTAAATGGAGAA ATCCTTCGAAATGCAGAGAGTGGTGCTATAGATGTAAAGTTTTTTGTCTTGTCTGAAAAGGGAGTGATTA TTGTTTCATTAATCTTTGATGGAAACTGGAATGGGGATCGCAGCACATATGGACTATCAATTATACTTCC ACAGACAGAACTTAGTTTCTACCTCCCACTTCATAGAGTGTGTGTTGATAGATTAACACATATAATCCGG AAAGGAAGAATATGGATGCATAAGGAAAGACAAGAAAATGTCCAGAAGATTATCTTAGAAGGCACAGAGA GAATGGAAGATCAGGGTCAGAGTATTATTCCAATGCTTACTGGAGAAGTGATTCCTGTAATGGAACTGCT TTCATCTATGAAATCACACAGTGTTCCTGAAGAAATAGATATAGCTGATACAGTACTCAATGATGATGAT ATTGGTGACAGCTGTCATGAAGGCTTTCTTCTCAAGTAA Clone variation with respect to NM_018325.2 870 c=>y >OriGene 5' read for NM_018325 unedited
TTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGTGCCTGCGCCCGCGGCG GCGGAGGCGCAGGCGGTGGCGAGTGGATATCTCCGGAGCATTTGGATAATGTGACAGTTG GAATGCAGTGATGTCGACTCTTTGCCCACCGCCATCTCCAGCTGTTGCCAAGACAGAGAT TGCTTTAAGTGGCAAATCACCTTTATTAGCAGCTACTTTTGCTTACTGGGACAATATTCT TGGTCCTAGAGTAAGGCACATTTGGGCTCCAAAGACAGAACAGGTACTTCTCAGTGATGG AGAAATAACTTTTCTTGCCAACCACACTCTAAATGGAGAAATCCTTCGAAATGCAGAGAG TGGTGCTATAGATGTAAAGTTTTTTGTCTTGTCTGAAAAGGGAGTGATTATTGTTTCATT AATCTTTGATGGAAACTGGAATGGGGATCGCAGCACATATGGACTATCAATTATACTTCC ACAGACAGAACTTAGTTTCTACCTCCCACTTCATAGAGTGTGTGTTGATAGATTAACACA TATAATCCGGAAAGGAAGAATATGGATGCATAAGGAAAGACAAGAAAATGTCCAGAAGAT TATCTTAGAAGGCACAGAGAGAATGGAAGATCAGGGTCAGAGTATTATTCCAATGCTTAC TGNAGAAGTGATTCCTGTAATGGAACTGCTTTCATCTATGAAATCACACAGTGTTCCTGA AGAATAGATATAGCTGATACAGTACTCAATGATGATGATATTGGTGACAGCTGTCATGAA GGCTTTCTTCTCAGTAAGAATTTTTCTTTTCATAAAGCTGGATGAAGCAGATACCATCTT ATGCTCACCCTATGACAGATTGGNAAGAAGAAATAACAGACTGA |
Restriction Sites | NotI-NotI |
ACCN | NM_145005 |
ORF Size | 510 bp |
Insert Size | 3400 |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
Reference Data | |
RefSeq | NM_145005.1, NP_659442.1 |
RefSeq Size | 1840 |
RefSeq ORF | 510 |
Locus ID | 203228 |
Gene Summary | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] Transcript Variant: This variant (1) lacks multiple exons in the central and 3' coding regions, and its 3' terminal exon extends beyond a splice site that is used in variant 3 . This results in a novel 3' UTR, compared to variant 3. It encodes isoform b which is significantly shorter, and its C-terminal amino acid is distinct, compared to isoform a. |
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC222418 | C9orf72 (Myc-DDK-tagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1 |
USD 420.00 |
|
RG222418 | C9orf72 (GFP-tagged) - Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1 |
USD 460.00 |
|
RC222418L1 | Lenti-ORF clone of C9orf72 (Myc-DDK-tagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1 |
USD 768.00 |
|
RC222418L2 | Lenti-ORF clone of C9orf72 (mGFP-tagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1 |
USD 620.00 |
|
RC222418L3 | Lenti-ORF clone of C9orf72 (Myc-DDK-tagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1 |
USD 620.00 |
|
RC222418L4 | Lenti-ORF clone of C9orf72 (mGFP-tagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 1 |
USD 620.00 |
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