DUSP3 (NM_004090) Human Untagged Clone

CAT#: SC108794

DUSP3 (untagged)-Human dual specificity phosphatase 3 (DUSP3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DUSP3
• Synonyms: VHR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC108794 sequence for NM_004090 edited (data generated by NextGen Sequencing)
  ATGTCGGGCTCGTTCGAGCTCTCGGTGCAGGATCTCAACGACCTGCTCTCGGACGGCAGC
  GGCTGCTACAGCCTCCCGAGCCAGCCCTGCAACGAGGTCACCCCGCGGATCTACGTGGGC
  AACGCGTCTGTGGCTCAGGACATCCCCAAGCTGCAGAAACTAGGCATCACCCATGTGCTG
  AACGCGGCTGAGGGCAGGTCCTTCATGCACGTCAACACCAATGCCAACTTCTACAAGGAC
  TCCGGCATCACATACCTGGGCATCAAGGCCAACGACACACAGGAGTTCAACCTCAGCGCT
  TACTTTGAAAGGGCTGCCGACTTCATTGACCAGGCTTTGGCTCAAAAGAATGGCCGGGTG
  CTCGTCCACTGCCGGGAAGGTTATAGCCGCTCCCCAACGCTAGTTATCGCCTACCTCATG
  ATGCGGCAGAAGATGGACGTCAAGTCTGCCCTGAGCATCGTGAGGCAGAACCGTGAGATC
  GGCCCCAACGATGGCTTCCTGGCCCAGCTCTGCCAGCTCAATGACAGACTAGCCAAGGAG
  GGGAAGTTGAAACCCTAG
  
  Clone variation with respect to NM_004090.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004090 unedited
  CAACAATTTGTAATACGACTCACTATAGGGCGGCCGCGNAATTCGCACGAGGGCCTCGCT
  TGCTCCTGCCGGGCGTGCAGGGCCCCGCCGCCGCCATGTCGGGCTCGTTCGAGCTCTCGG
  TGCAGGATCTCAACGACCTGCTCTCGGACGGCAGCGGCTGCTACAGCCTCCCGAGCCAGC
  CCTGCAACGAGGTCACCCCGCGGATCTACGTGGGCAACGCGTCTGTGGCTCAGGACATCC
  CCAAGCTGCAGAAACTAGGCATCACCCATGTGCTGAACGCGGCTGAGGGCAGGTCCTTCA
  TGCACGTCAACACCAATGCCAACTTCTACAAGGACTCCGGCATCACATACCTGGGCATCA
  AGGCCAACGACACACAGGAGTTCAACCTCAGCGCTTACTTTGAAAGGGCTGCCGACTTCA
  TTGACCAGGCTTTGGCTCAAAAGAATGGCCGGGTGCTCGTCCACTGCCGGGAAGGTTATA
  GCCGCTCCCCAACGCTAGTTATCGCCTACCTCATGATGCGGCAGAAGATGGACGTCAAGT
  CTGCCCTGAGCATCGTGAGGCAGAACCGTGAGATCGGCCCCAACGATGGCTTCCTGGCCC
  AGCTCTGCCAGCTCAATGACAGACTAGCCAAGGAGGGGAAGTTGAAACCCTAGGGCACCC
  CCACCGCCTCTGCTCGAGAGGTCCGTGGGGGAGGCCGTGGGCAAAGGTGTCCCGAGCTGC
  CATGTTTAAGAAACACACTGTACCCTGCTCCCAGCATCACAAAGCACTTGTCTACAAGTG
  TGTCCCAACACAGTCCTGNGCCACTTTCCCCACCCTGGGGAGCACATAAAGAAAGCTGCC
  CAGGGGGGCGTNCCTGCTCCCCAGNTGGCCTGGTTCTGTACTCATGAAGNCTTTTCCTGA
  GAAGGGGCTCANAGGGGGAAGCCTGGGCCTGCAGCTTCCGAGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004090 unedited
  ATACTTTGGACCCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTCCTTTA
  AAACAGTAGCATCTTAACTTGTGGCACAAAAGGCACCAACATTCCCTTTCCAAACCATCC
  ATCACCATGGGTGGAAGGCAGCGCCACCTGCTGGCCATCATATTATGGCTCACATACCCA
  TAATTTCCTTGCGGTGCTGAATTCCAAGTGGGGATTATTAGAGACCCCTCAGAGCCAAAA
  GGGGACCTTAGAGGTCTTCTAGATGAGTCCCCTCATTTGTAGGTGGTGGTTTCTGGATAA
  CTCAGAGTGGCAGGGACACAGACGAGCCTGTGGAAAGGTATACTGCTTTAAGATTGAGAA
  GAAAACCATTTGGCGCTCTAATTTTGCCTGGATGGTGCTCTGTCAGCCAAAGAAAGGGAA
  CAGGTCTGGGGAGGGGGTAAGGGCACCCTGAGTTCCTGTTCCATCACTTCCCAGGCAGTA
  GAAGGCTGTCCAGGAACAGTTCCCATCCGCAGCTGGGCATGTGTTGGCTCTTACACAAGA
  GACTCTACTTTTACTTGACGAACTAAGACCCAATCTTCCACAGTAAATACGGCGCCTCAG
  GGCCGAAGGACTATCACCAAACCTCAGTTATCTATTAAACCTACTCTCCACCGCCAGGGA
  GTAACTTTCCAAATGCCCATTCTCCCCCATGCCCACCACAACCTCCATACCCCCTCTTTC
  TTCCCCCCCCACCCTCCCCTTGCCCGTTCACCTGTCTGATTTGCCCCATCCGCTATTAAC
  TTTCCGTACCTCCTTACGNTACCCCCCACCCTTTTTCCTGTCCTTTACACTAGTTTAGTT
  TAATCCTTTTATGCCCCCCTCCGCCCCCCCCCTTCTTATCTCCCTTCCCTCCCTGTTCCC
  CCCCCCTCTCCTTCCTTTTTTTTTCCCCCCCTTCTCTTCCTCCCTTCCCTCTTCCTACTC
  C
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004090
• ORF Size: 558 bp
• Insert Size: 3670
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004090.2, NP_004081.1
• RefSeq Size: 4116
• RefSeq ORF: 558
• Locus ID: 1845
• Domains: DSPc
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: MAPK signaling pathway
• Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]