Lamin B Receptor (LBR) (NM_002296) Human Untagged Clone

CAT#: SC109384

LBR (untagged)-Human lamin B receptor (LBR), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LBR
• Synonyms: C14SR; DHCR14B; LMN2R; PHA; PHASK; TDRD18
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109384 sequence for NM_002296 edited (data generated by NextGen Sequencing)
  ATGCCAAGTAGGAAATTTGCCGATGGTGAAGTGGTAAGAGGTCGATGGCCTGGGAGTTCA
  CTTTATTATGAAGTAGAAATTCTGAGCCACGACAGCACCTCCCAGCTTTACACTGTAAAG
  TATAAAGATGGAACAGAGCTTGAATTGAAAGAGAATGATATTAAGCCTTTAACTTCCTTT
  AGGCAAAGGAAAGGTGGCTCAACTTCCAGTTCCCCTTCCAGACGCCGAGGGAGTCGATCA
  AGGTCACGCTCCCGATCCCCTGGTCGACCACCTAAAAGTGCCCGCCGATCTGCTTCTGCT
  TCCCACCAGGCCGACATTAAGGAAGCAAGGAGGGAAGTGGAAGTTAAATTGACTCCGCTG
  ATTCTGAAGCCATTTGGAAATAGCATCAGCAGATATAATGGGGAGCCTGAGCATATTGAG
  AGAAATGACGCACCTCATAAAAATACACAGGAAAAATTCAATTTGTCACAAGAAAGCAGT
  TACATAGCAACACAGTATAGCCTTCGTCCAAGAAGAGAAGAAGTCAAATTAAAAGAAATA
  GATTCTAAGGAAGAAAAATACGTTGCAAAAGAACTGGCAGTGAGAACCTTTGAAGTGACC
  CCCATCCGGGCAAAGGACTTGGAGTTTGGAGGAGTACCTGGTGTGTTTCTCATCATGTTT
  GGCCTGCCTGTGTTCCTCTTCCTGTTGCTGTTGATGTGTAAACAGAAAGATCCCAGTCTT
  CTGAATTTCCCTCCTCCTTTGCCAGCTTTGTATGAGTTATGGGAAACCAGAGTATTTGGG
  GTCTACCTCCTGTGGTTTTTGATTCAAGTCCTGTTCTACCTACTGCCAATTGGAAAGGTT
  GTAGAAGGAACGCCTCTTATTGATGGAAGAAGACTCAAGTATAGATTAAATGGATTCTAT
  GCTTTTATCCTGACATCTGCAGTCATCGGAACATCTCTCTTCCAGGGCGTAGAGTTTCAT
  TACGTGTACAGTCATTTTCTTCAGTTTGCACTTGCGGCCACTGTTTTTTGTGTGGTCTTG
  AGTGTGTATCTCTACATGCGCTCTTTGAAAGCGCCCCGGAATGACCTGTCGCCTGCCAGC
  TCTGGAAATGCTGTCTATGATTTCTTCATTGGCCGTGAATTAAACCCTCGAATTGGTACT
  TTTGATCTCAAATACTTTTGTGAATTGCGCCCCGGATTGATTGGATGGGTGGTTATTAAC
  TTGGTGATGCTTTTGGCTGAAATGAAAATACAGGACCGCGCTGTTCCATCCTTGGCCATG
  ATTTTAGTTAATAGTTTCCAGCTTCTCTATGTGGTGGATGCTCTCTGGAATGAGGAAGCG
  TTGTTGACGACCATGGACATCATCCACGATGGATTTGGATTCATGCTGGCTTTTGGAGAC
  TTGGTGTGGGTTCCCTTTATTTACAGCTTCCAAGCCTTTTATTTAGTCAGTCATCCAAAT
  GAAGTGTCTTGGCCAATGGCTTCTCTAATTATTGTTCTGAAACTTTGTGGTTATGTAATC
  TTCCGAGGTGCAAATTCTCAGAAAAATGCATTCCGGAAAAATCCCAGTGATCCAAAGCTT
  GCACATTTAAAAACCATTCATACTTCAACGGGAAAAAATCTTCTAGTTTCTGGATGGTGG
  GGCTTTGTTCGCCACCCCAATTACTTGGGTGATCTCATCATGGCCTTGGCGTGGTCCCTC
  CCATGTGGTTTTAACCACATTCTGCCTTATTTCTACATAATTTATTTCACCATGTTGCTT
  GTCCACCGAGAAGCTCGTGACGAGTACCACTGTAAGAAGAAATACGGCGTGGCTTGGGAA
  AAGTACTGTCAGCGTGTGCCCTACCGTATATTTCCATACATCTACTAA
  
  Clone variation with respect to NM_002296.3
  117 g=>a;461 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002296 unedited
  TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGCGCGTGGATCT
  GCCGCCGGGTTGCTGTGCGACTATTCTCCGGGAGCCGTCCGTGTCACCGCCGGAACCTGG
  CGCAGGTTAATTATAGAAAATGCCAAGTAGGAAATTTGCCGATGGTGAAGTGGTAAGAGG
  TCGATGGCCTGGGAGTTCACTTTATTATGAAGTAGAAATTCTGAGCCACGACAGCACCTC
  CCAGCTTTACACTGTAAAGTATAAAGATGGAACAGAGCTTGAATTGAAAGAGAATGATAT
  TAAGCCTTTAACTTCCTTTAGGCAAAGGAAAGGTGGCTCAACTTCCAGTTCCCCTTCCAG
  ACGCCGAGGGAGTCGATCAAGGTCACGCTCCCGATCCCCCGGTCGACCACCTAAAAGTGC
  CCGCCGATCTGCTTCTGCTTCCCACCAGGCCGACATTAAGGAAGCAAGGAGGGAAGTGGA
  AGTTAAATTGACTCCGCTGATTCTGAAGCCATTTGGAAATAGCATCAGCAGATATAATGG
  GGAGCCTGAGCATATTGAGAGAAATGACGCACCTCATAAAAATACACAGGAAAAATTCAA
  TTTGTCACAAGAAAGCAGTTACATAGCAACACAGTATAGCCTTCGTCCAAGAAGAGAAGA
  AGTCAAATTAAAAGAAATAGATTCTAAGGAAGAANAATACGTTGCANAAGAACTGGCAGT
  GAGAACCTTTNGAGTGACCCCCATCCGGGCAAAGGACTTGGNNAGTTGGAGGAGTACCTG
  GTGTGTTTCTCATCATGGTTGGCCTGGCTGTAGTCCTCTTCCTGGNTGCTGTGATGTGTA
  ACAGAAAGATCCCAGTCTTCTGAATTTCCTTCTNCTTTGCAGCTTGTATGAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002296 unedited
  GCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTGATCAAAAGTTGCTACAT
  TTTATTTTCAACTTAAAACTTCATTATAAAATTTGCCAAATAAACATGTCAAAAACAAAC
  TTAAAAACAAAGTGTAGCTGATATCCAGAAATTGCAGCACTGTATTGATAAAGGGCTCTT
  TTCATTACCAGGGAAAGAATTTAATGTCCTTCCTTCCTCCCCAAAAGCTTCCTTGGTGCA
  ATCCAGTACAGAAAACGCCACCACTTTCTGATGCCAGGAGAAAAGCAAAATAAAAAAACT
  GCTTGCACACATTAGCACTGATAAAACAATGACAATTTCACTAAAAGAATGTTTAAAGAC
  TACCGGATGCTGGAGCAAACCAACTTCATGACTGCATTAACATAAGCTAAGTTACATACA
  CTTCAAATGCAGTATAGAATTAACACTGCATATCTAAATGGCTCATATATAAAATGTGTA
  ATTAAAACCCAAACATACACACTATGTTTATTACATTCCCCTACATTGAAAGTACTGAGA
  ACAATTTAACTCTGAACACAAAAGTTTAGTGAATTTGCTACTGTTCCATTACAGGACAAT
  TAAAAATGAGACTATATCAACTTCACTAGAATTTAATTGCTAAAGCTACCTTATGCACAT
  CTATTAAACTAAAAGAAACGACTTTAACCCCTTCAGTTGTTTTTAAGACAGCACTCCTTT
  ACAGGGAGTCANGTTNGGGTAATATAAGGATACCTAAAAAATACAGTATAAACTGCATAA
  GCTTAACAGTAGCCAAAACACTGATGGACCTTTTAAAAGTCAAAAATATATAAAAATATT
  AGCCTGGAATGGCAAATTNTCAACACCCGATCTGGTAAAAATGGTTAATATGGATGGCCT
  CCAAAAAATATACTATNCTATTTTTTTCTATTTGCACAGTTGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002296
• Insert Size: 4200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002296.2, NP_002287.2
• RefSeq Size: 3806 bp
• RefSeq ORF: 1848 bp
• Locus ID: 3930
• Cytogenetics: 1q42.12
• Domains: ERG4_ERG24, TUDOR
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: 'The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.