DYRK2 (NM_003583) Human Untagged Clone

CAT#: SC109928

DYRK2 (untagged)-Human dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DYRK2
• Synonyms: FLJ21217; FLJ21365
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_003583 edited
  ATGAATGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAGGTTCAACAGTTG
  TTTGAGGATAACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACA
  GTGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAGCTGGACAGCATTCATAGACGG
  CAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGGGAAGGTGAAAGCCACCCCC
  ATGACACCTGAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCAT
  GAGATTTTCAGCTACCCTGAAATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGC
  ATGACAGGTGGGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATATGTGCAGGTG
  CCCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTT
  GGGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAGCACGTGGCCCTAAAGATGGTG
  CGGAATGAGAAGCGCTTCCACCGGCAAGCAGCGGAGGAGATCCGAATCCTGGAACACCTG
  CGGAAGCAGGACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTC
  CGCAACCACATCTGCATGACGTTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAG
  AAGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCACTCGATTCTG
  CAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAAC
  ATTTTGTTAAAGCAGCAGGGTAGAAGCGGTATTAAAGTAATTGATTTTGGCTCCAGTTGT
  TACGAGCATCAGCGTGTCTACACGTACATCCAGTCGCGTTTTTACCGGGCTCCAGAAGTG
  ATCCTTGGGGCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCA
  GAGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGATGAAGGGGACCAGCTGGCCTGT
  ATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGATGCATCCAAACGAGCCAAA
  AATTTTGTGAGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGC
  TCTGTGGTCCTAAACGGAGGCCGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGC
  AGAGAGTGGGGTAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGACTTCTTAAAA
  CAGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCC
  TGGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAGAAAACGTCAGTGAAAAGGATA
  ACTGAGAGCACCGGTGCTATCACATCTATATCCAAGTTACCTCCACCTTCTAGCTCAGCT
  TCCAAACTGAGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGG
  ACAGTGTTGCCAAAACTTGTTAGCTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003583 unedited
  GTTCACATTTTGTAATACGACTCACTATTAGGGCGGCCGCGAATTCGCACGAGGGCGGCG
  CGCAGGGGAGGGCGAGGCATGTGCACGGGCCGGAGGGTGCTGCAGCCGCCCGAGGAAGAG
  GAGGACGGCGGCGAGGAGGAGAGCGGGGGGCTCGCGGCGGCGGGCCCCGGCCGAGGGGAT
  GCAGTGGACTGTGTGTGTCTGGCTGTAGCAGACGCGAGGCGGCGACGAGGCGCCGGGGAC
  CCGCGCGAGGGGCGGCCGGGAGGCGGCGGCGGCGGCCGCCAGAAGTAGCAGCAGGACCGG
  CGGCGGCGACGGCAGCCCTGAAATGCATTTTCCTCTCCAGCGGCCATGTTAACCAGGAAA
  CCTTCGGNCGCCGCTCCCGCCGCCTACCCGACCGATTGGCGGCAGTAAGCACACAATGAA
  TGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAAGTTCAACAGNTGTGTTG
  AGGATACAGTAACCAGCGGACAGTGCTCACGACACAACCAATGGGGCTACCACAGTGGGG
  CAAACCGGCTTGCCACTGGTGGCAGAACGGCAGCTTGACCGCATTCATAGACCGGAAGGG
  AGCTTCACCTCTCTATAGTCCATCTGAAGCATTGGGAANGTGAAAAGCCCCCCCCCTGAC
  ACCTGGACCAGCCATGGAGCCATACATGCGCAAACCTCCCAGGCTTTTGGACACCATGAG
  AATTTTAGCTATCCTGGAATATATTTTCTTGGGGCTTAATGCTAAAAAACGCCCCGGCCT
  TACACGGTGGGCCCAACAATTGTGGGCTTTGTAGATGAGCCAAGATACTATTTGCCAGGG
  CCCCCCCAACACTTGGGTTTAACGGTTAAAGGCCTCTAGGGCTTTGGGAAAGGGAGCCTT
  TGGCCAATGTGCAAGGCGTCTATATCAACAATCCCCCACCCTTGCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003583
• ORF Size: 1587 bp
• Insert Size: 5880
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003583.2, NP_003574.1
• RefSeq Size: 3466
• RefSeq ORF: 1587
• Locus ID: 8445
• Domains: pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) does not include the 149 bp insert in the 5' end of the transcript and thus results in a shorter amino-terminal protein.