DR3 (TNFRSF25) (NM_003790) Human Untagged Clone

CAT#: SC109975

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TNFRSF25
• Synonyms: APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5; TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109975 sequence for NM_003790 edited (data generated by NextGen Sequencing)
  ATGGAGCAGCGGCCGCGGGGCTGCGCGGCGGTGGCGGCGGCGCTCCTCCTGGTGCTGCTG
  GGGGCCCGGGCCCAGGGCGGCACTCGTAGCCCCAGGTGTGACTGTGCCGGTGACTTCCAC
  AAGAAGATTGGTCTGTTTTGTTGCAGAGGCTGCCCAGCGGGGCACTACCTGAAGGCCCCT
  TGCACGGAGCCCTGCGGCAACTCCACCTGCCTTGTGTGTCCCCAAGACACCTTCTTGGCC
  TGGGAGAACCACCATAATTCTGAATGTGCCCGCTGCCAGGCCTGTGATGAGCAGGCCTCC
  CAGGTGGCGCTGGAGAACTGTTCAGCAGTGGCCGACACCCGCTGTGGCTGTAAGCCAGGC
  TGGTTTGTGGAGTGCCAGGTCAGCCAATGTGTCAGCAGTTCACCCTTCTACTGCCAACCA
  TGCCTAGACTGCGGGGCCCTGCACCGCCACACACGGCTACTCTGTTCCCGCAGAGATACT
  GACTGTGGGACCTGCCTGCCTGGCTTCTATGAACATGGCGATGGCTGCGTGTCCTGCCCC
  ACGAGCACCCTGGGGAGCTGTCCAGAGCGCTGTGCCGCTGTCTGTGGCTGGAGGCAGATG
  TTCTGGGTCCAGGTGCTCCTGGCTGGCCTTGTGGTCCCCCTCCTGCTTGGGGCCACCCTG
  ACCTACACATACCGCCACTGCTGGCCTCACAAGCCCCTGGTTACTGCAGATGAAGCTGGG
  ATGGAGGCTCTGACCCCACCACCGGCCACCCATCTGTCACCCTTGGACAGCGCCCACACC
  CTTCTAGCACCTCCTGACAGCAGTGAGAAGATCTGCACCGTCCAGTTGGTGGGTAACAGC
  TGGACCCCTGGCTACCCCGAGACCCAGGAGGCGCTCTGCCCGCAGGTGACATGGTCCTGG
  GACCAGTTGCCCAGCAGAGCTCTTGGCCCCGCTGCTGCGCCCACACTCTCGCCAGAGTCC
  CCAGCCGGCTCGCCAGCCATGATGCTGCAGCCGGGCCCGCAGCTCTACGACGTGATGGAC
  GCGGTCCCAGCGCGGCGCTGGAAGGAGTTCGTGCGCACGCTGGGGCTGCGCGAGGCAGAG
  ATCGAAGCCGTGGAGGTGGAGATCGGCCGCTTCCGAGACCAGCAGTACGAGATGCTCAAG
  CGCTGGCGCCAGCAGCAGCCCGCGGGCCTCGGAGCCGTTTACGCGGCCCTGGAGCGCATG
  GGGCTGGACGGCTGCGTGGAAGACTTGCGCAGCCGCCTGCAGCGCGGCCCGTGA
  
  Clone variation with respect to NM_003790.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003790 unedited
  ACGGATTTTGTAATCACGATTCACTATAGGCGGCCGCGCAATTCGCACGAGNAGGCGGAA
  CCTCGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCTGGGCGCCCGTCGGAGGGCTATGG
  AGCAGCGGCCGCGGGGCTGCGCGGCGGTGGCGGCGGCGCTCCTCCTGGTGCTGCTGGGGG
  CCCGGGCCCAGGGCGGCACTCGTAGCCCCAGGTGTGACTGTGCCGGTGACTTCCACAAGA
  AGATTGGTCTGTTTTGTTGCAGAGGCTGCCCAGCGGGGCACTACCTGAAGGCCCCTTGCA
  CGGAGCCCTGCGGCAACTCCACCTGCCTTGTGTGTCCCCAAGACACCTTCTTGGCCTGGG
  AGAACCACCATAATTCTGAATGTGCCCGCTGCCAGGCCTGTGATGAGCAGGCCTCCCAGG
  TGGCGCTGGAGAACTGTTCAGCAGTGGCCGACACCCGCTGTGGCTGTAAGCCAGGCTGGT
  TTGTGGAGTGCCAGGTCAGCCAATGTGTCAGCAGTTCACCCTTCTACTGCCAACCATGCC
  TAGACTGCGGGGCCCTGCACCGCCACACACGGCTACTCTGTTCCCGCAGAGATACTGACT
  GTGGGACCTGCCTGCCTGGCTTCTATGAACATGGCGATGGCTGCGTGTCCTGCCCCACGA
  GCACCCTGGGGAGCTGTCCAGAGCGCTGTGCCGCTGTCTGTGGCTGGAGGCAGATGTTCT
  GGGTCCANGGTGCTCTGGCTGGCCTTGTGGTCCCNCTCCTGCTTGGGGCCACCCTGACCT
  ACACATACCGCCACTGCTGGGCCTCACAGCCCTGGTTACTGCANATGAAGCTGGGATGGG
  AGCTCTGACCCCACCCACGGCCACCCATCTGTCACCCTTGGACAGCGCCCACAACCCTCT
  AGCACCTCCTGAAGGCAGTGAGAAGATCTGCCACGGTCCAGTGGTTGGGTAACAGCTGGA
  CCCTGGCTACCCCCAGACCAGGAAGCGCTTGGCGCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003790 unedited
  CGGCCTCTATGNACCGCGCCGCATTCTANGATCGGTTTTTTTTTTTTTTTTTTGTTTTGT
  TTTCTTTCCAGATTTAATACCGCGATCTCAGCCAAACTCCGGCCGAGAAGTTGAGAAATG
  TCTTCACCCCCTCTCGACATTCGTTCGTGCTTCTTCGCCTTGGCTGGAGCGATAGGGGCG
  AGCAGGGGTGGGGCCGGCTGGTGCTGCTACGCAGGGCCGTGCCAGCGGCTTAATAAGTGA
  CATAAAATGTCTACACGCATAAGTAACCGTACTTAGGGCTTCTGCAAGGGCCACCAGAGC
  GCCTAGGTGGCAAGTGGGCGCCGTGTCACGGGCCGCGCTGCAAGCGGCTGCGCAAGTCTT
  CCACGCAGCCGTCCAGCCCCATGCGCTCCAGGGCCGCGTAAACGGCTCCGAGGCCCGCGG
  GCTGCTGCTGGCGCCAGCGCTTGAGCATCTCGTACTGCTGGTCTCGGAAGCGGCCGATCT
  CCACCTCCACGGCTTCGATCTCTGCCTCGCGCAGCCCCAGCGTGCGCACGAACTCCTTCC
  AGCGCCGCGCTGGGACCGCGTCCATCACGTCGTAAAGCTGCGGGCCCGGCTGCAGCATCA
  TGGCTGGCGAGCCGGCTGGGGACTCTGGCGAGAGTGTGGGCGCAGCAGCGGGGCCAAGAG
  CTCTGCTGGGCAACTGGTCCCCAGACCATGTCACCTGCGGGCAGAGCGCCTCCTGGGTCT
  CGGGGTAGCCAGGGGGTCAGCTGTTACCCCCAACTGGACGGTGCAGATACTCTCACTGCT
  GTCAAGAAGTGCTANAAAGGTGTGGGCGCTGTCAAAGGTGACANATGGTGGGCCGGGGTG
  GGGTCAGAGCCTCATTCCACCTCATTTGAGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003790
• ORF Size: 1254 bp
• Insert Size: 1650
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003790.2, NP_003781.1
• RefSeq Size: 1638
• RefSeq ORF: 1254
• Locus ID: 8718
• Domains: DEATH, TNFR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks two coding segments, both of which result in a frameshift, when compared to variant 1. The resulting isoform (2) has a shorter and distinct internal region, as compared to isoform 1.