BAIAP2 (NM_017450) Human Untagged Clone

CAT#: SC110154

BAIAP2 (untagged)-Human BAI1-associated protein 2 (BAIAP2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BAIAP2
• Synonyms: BAP2; FLAF3; IRSP53
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110154 sequence for NM_017450 edited (data generated by NextGen Sequencing)
  ATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGACCATC
  ATGGAGCAGTTCAACCCTAGCCTCCGGAACTTCATCGCCATGGGGAAGAATTACGAGAAG
  GCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGCCCTGGTGAAGATGGGG
  GAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGAGACGTTCTCTTCCAGATGGCT
  GAAGTCCACAGGCAGATCCAGAATCAGCTGGAAGAAATGCTGAAGTCTTTTCACAACGAG
  CTGCTTACGCAGCTGGAGCAGAAGGTGGAGCTGGACTCCAGGTATCTGAGTGCTGCGCTG
  AAGAAATACCAGACTGAGCAAAGGAGCAAAGGCGACGCCCTGGACAAGTGTCAGGCTGAG
  CTGAAGAAGCTTCGGAAGAAGAGCCAGGGCAGCAAGAATCCTCAGAAGTACTCGGACAAG
  GAGCTGCAGTACATCGACGCCATCAGCAACAAGCAGGGCGAGCTGGAGAATTACGTGTCC
  GACGGCTACAAGACCGCACTGACAGAGGAGCGCAGGCGCTTCTGCTTCCTGGTGGAGAAG
  CAGTGCGCCGTGGCCAAGAACTCCGCGGCCTACCACTCCAAGGGCAAGGAGCTGCTGGCG
  CAGAAGCTGCCGCTGTGGCAACAGGCCTGTGCCGACCCCAGCAAGATCCCGGAGCGCGCG
  GTGCAGCTCATGCAGCAGGTGGCCAGCAACGGCGCCACCCTCCCCAGCGCCCTGTCGGCC
  TCCAAGTCCAACCTGGTCATTTCCGACCCCATTCCGGGGGCCAAGCCCCTGCCGGTGCCC
  CCCGAGCTGGCACCGTTCGTGGGGCGGATGTCTGCCCAGGAGAGCACACCCATCATGAAC
  GGCGTCACAGGCCCGGATGGCGAGGACTACAGCCCGTGGGCTGACCGCAAGGCTGCCCAG
  CCCAAATCCCTGTCTCCTCCGCAGTCTCAGAGCAAGCTCAGCGACTCCTACTCCAACACA
  CTCCCCGTGCGCAAGAGCGTGACCCCAAAAAACAGCTATGCCACCACCGAGAACAAGACT
  CTGCCTCGCTCGAGCTCCATGGCAGCCGGCCTGGAGCGCAATGGCCGTATGCGGGTGAAG
  GCCATCTTCTCCCACGCTGCTGGGGACAACAGCACCCTCCTGAGCTTCAAGGAGGGTGAC
  CTCATTACCCTGCTGGTGCCTGAGGCCCGCGATGGCTGGCACTACGGAGAGAGTGAGAAG
  ACCAAGATGCGGGGCTGGTTTCCCTTCTCCTACACCCGGGTCTTGGACAGCGATGGCAGT
  GACAGGCTGCACATGAGCCTGCAGCAAGGGAAGAGCAGCAGCACGGGCAACCTCCTGGAC
  AAGGACGACCTGGCCATCCCACCCCCCGATTACGGCGCCGCCTCCCGGGCCTTCCCCGCC
  CAGACGGCCAGCGGCTTCAAGCAGAGGCCCTACAGTGTGGCCGTGCCCGCCTTCTCCCAG
  GGCCTGGATGACTATGGAGCGCGGTCCATGAGCAGTGGCAGCGGCACGCTGGTGTCCACA
  GTGTGA
  
  Clone variation with respect to NM_017450.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_017450 unedited
  TGCATATTTGTATACGACTCCTATAGGCGGCNCGCGAATTCGCACGAGGGTCCGCTTTCG
  TCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCT
  GTGGTGCAGCCGGGACCCAGGACCATGTCTCTGTCTCGCTCAGAGGAGATGCANNCCGGC
  TCACGGAAAATGTCTATAAGACCATCATGGAGCAGTTCAACCCTAGCCTCCGGAACTTCA
  TCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCT
  ACTTTGACGCCCTGGTGAAGATGGGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAAC
  TCGGAGACGTTCTCTTCCAGATGGCTGAAGTCCACAGGCAGATCCAGAATCAGCTGGAAG
  AAATGCTGAAGTCTTTTCACAACGAGCTGCTTACGCAGCTGGAGCAGAAGGTGGAGCTGG
  ACTCCAGGTATCTGAGTGCTGCGCTGAAGAAATACCAGACTGAGCAAAGGAGCAAAGGCG
  ACGCCCTGGACAAGTGTCAGGCTGAGCTGAAGAAGCTTCGGAAGAAGAGCCAGGGCAGCA
  AGAATCCTCAGAAGTACTCGGACAAGGAGCTGCAGTACATCGACGCCATCAGCAACAAGC
  AGGGCGAGCTGGAGAATTACGTGTCCGACGGCTACAAGACCGCACTGACAGAGGAGCGCA
  NGCGCTTCTGCTTCCTGGTGGAGAAGCAGTGCGCCGTGGCCAAGAACTCCGCGGNCTACC
  ACTCCCAGGGCAAGGAGCTGCTGGCGCANAAGCTGCCGCTGTGCACCAGGCCTGTGCCGA
  CCCAGCAAGATCCCCGACGCGCCGTGCAGTTCATGCACAAGGTGGCCGCACCGGTGCACC
  CTCCCAAGCCCTGTGGCCTCCAGTCACCTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_017450 unedited
  CCGCGGGCCGCAATCTAAAGTCGAGTNNTTNTTTTTTTTTTTTCTTTTTTTTTTTTTTTT
  AAGATTTTTCTTTTTCTTCAAACTTTAGACCTGGCTCACGGCGAGCCTTAAAAAACAGTG
  AGTGCCACAGACACTGCAGGGTGAGGCCGAGGGTGCCCCGCACGGCCCAGCAGGTCCTGC
  CTGGCAGTTTCTGCTCAAAAGGCTGGGACACACAGGATGGGGCGCGTAAACACAGGGGAG
  GGGGGGCGGATGGAGCAGCACCATGGACCCTGGGGGATCACAGAGTCTGGGGTCACCAAC
  CAAAAGGCATGGGGCAGGTGGAAAAGAAAAACAACCCAAGAACAAACCAGCGAGAGCTGA
  GGAGGAAAACGGACGAGACCAGGGGGAAGGCGCGGAAGCTCTTCAGAGCAGCGGCTGCCC
  GGNGTCAGCGTCCTCACACTGTGGACACCAGCGTGCCGCTGCCACTGCTCATGGACCGCG
  CTCCATAGTCATCCAGGCCCTGGAGAAGGCGGGCACGGCCACACTGTANGGCCTCTGCTT
  GAAGCCGCTGGCCGTCTGGGCGGAGAAGGCCCGGNAGGCNGCCGCCGTAATCGGNGGGTG
  GGATGGGCCAGTCGTCCTTTGTCAGGAGGNTGCCCGTGCTGCTGCTCTTCCCTTGCCTGC
  AGCTCATGTGCAGCCTGTCACTGGCATCGCTGNCCAAGACCCGGGTGTAGGAAAAGGGGA
  CCCAACCCCGGATCTTGGCTCTTTCACTCTTCTCGNAAGGGCAGCCATCGGGGGGCCTAA
  AGCACCAACAGGGGTATGAGGTCACCCTTCTTGAACCTCAGGAAGGGGCTGTTGCCCCAC
  CACGCGGGAAAAAAAGGCGCTCAACCCGATACCGCCATTGGCCTCCAGGCCCGGTGCCAT
  GGATTTGAGCGAGGCAGAGTCTTGTTTGGGGGGGGCAAATTTGGTTTTGGGGGACCCCTT
  TCGCCCGGGGAGGTGTTGAAATAGAATCTTAAACTCCTCTTGACATGGGAGAAACAGGAT
  TGGGCTTGCACT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_017450
• ORF Size: 1566 bp
• Insert Size: 2260
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_017450.1, NP_059344.1
• RefSeq Size: 3168
• RefSeq ORF: 1566
• Locus ID: 10458
• Domains: SH3
• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Regulation of actin cytoskeleton
• Gene Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2009]
  Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-alpha, short form, or variant S. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.