RBFOX1 (NM_018723) Human Untagged Clone

CAT#: SC110486

RBFOX1 (untagged)-Human RNA binding protein, fox-1 homolog (C. elegans) 1 (RBFOX1), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RBFOX1
• Synonyms: 2BP1; A2BP1; FOX-1; FOX1; HRNBP1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110486 sequence for NM_018723 edited (data generated by NextGen Sequencing)
  ATGAATTGTGAAAGAGAGCAGCTAAGGGGTAATCAGGAAGCAGCCGCTGCCCCTGACACA
  ATGGCTCAGCCTTACGCTTCGGCCCAGTTTGCTCCCCCGCAGAACGGTATCCCCGCGGAA
  TACACGGCCCCTCATCCCCACCCCGCGCCAGAGTACACAGGCCAGACCACGGTTCCCGAG
  CACACATTAAACCTGTACCCTCCCGCCCAGACGCACTCCGAGCAGAGCCCGGCGGACACG
  AGCGCTCAGACCGTCTCTGGCACCGCCACACAGACAGATGACGCAGCACCGACGGATGGC
  CAGCCCCAGACACAACCTTCTGAAAACACGGAAAACAAGTCTCAGCCCAAGCGGCTGCAT
  GTCTCCAATATCCCCTTCAGGTTCCGGGATCCGGACCTCAGACAAATGTTTGGTCAATTT
  GGTAAAATCTTAGATGTTGAAATTATTTTTAATGAGCGAGGCTCAAAGGGATTTGGTTTC
  GTAACTTTCGAAAATAGTGCCGATGCGGACAGGGCGAGGGAGAAATTACACGGCACCGTG
  GTAGAGGGCCGTAAAATCGAGGTAAATAATGCCACAGCACGTGTAATGACAAATAAAAAG
  ACCGTCAACCCTTATACAAATGGCTGGAAATTGAATCCAGTTGTGGGTGCAGTCTACAGT
  CCCGAATTCTATGCAGGCACGGTCCTGTTGTGCCAGGCCAACCAGGAGGGATCTTCCATG
  TACAGTGCCCCCAGTTCACTTGTATATACTTCTGCAATGCCAGGCTTCCCGTATCCAGCA
  GCCACCGCCGCGGCCGCCTACCGAGGGGCGCACCTGCGAGGCCGCGGTCGCACCGTGTAC
  AACACCTTCAGGGCCGCGGCGCCCCCGCCCCCGATCCCGGCCTACGGCGGTGTTGTTTAC
  CAGGATGGATTTTATGGTGCAGACATTTATGGTGGTTATGCTGCATACCGCTACGCCCAG
  CCTACCCCTGCCACTGCCGCTGCCTACAGTGACAGTTACGGACGAGTTTATGCTGCCGAC
  CCCTACCACCACGCACTTGCTCCAGCCCCCACCTACGGCGTTGGTGCCATGAATGCTTTT
  GCACCTTTGACTGATGCCAAGACTAGGAGCCATGCTGATGATGTGGGTCTCGTTCTTTCT
  TCATTGCAGGCTAGTATATACCGAGGGGGATACAACCGTTTTGCTCCATACTAA
  
  Clone variation with respect to NM_018723.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018723 unedited
  TTCAACAATTTGTAATACGACTCACTATAGGGCGGCNCGCGAATTCGCACGAGGCTCTTG
  CTGGCCGTCTGGGTGCACACACCGCTCCCTCGATCACCCCAGCCCCCTTCCTGGTCTCCC
  GAGCGCGGGGTTTGAAGGTCACCTCCTTTCCAGTCCCCGTGCGAGCCGCGCTGCCGCCGC
  CTCCTCCAGCCAGAGTCGGTGGGACTGGCTGCGCTGCCCTGAAGTGGTTCTCCAAGCAGC
  GCGGAGGGTGGCGGACGGCGGACGGAGCCCAGGGGCCGCGTCGGGTGGGGAAACCCGAAC
  TCGCGGAGGGGAATCCCTCCCCCTCCGCCCCAGCCCCCCAGCAGCACCCGCGGTGGGGCG
  GGGGCGCTCTGCCAGCCCCGGGAACAGCAGAGGCGGCGGCACTGGCTGGACCCACGCGCG
  CGCCTCCGGGGCTGAAGAAGGAAGGAGTGAGCCGAGCCGAGCACCCCACATCTGGAGGGG
  ACAGCCAGCCGTGGGCCCCGCCCCGGCGTCCGGAGCAGGAGAACTCCGAGCTTCTTGCCC
  AGGCAGAGAGAGCAGGAGCGGACCGCGCGCCCGGGATTGAGAGTCCTTGCGCTCCAGACC
  CCCACCCAGTGGCCGCCAGGGTCCCCGCCTGTCCGGACCCTCGCCGCGCCCAGGCAGGCG
  CGCCAGGGCGGTTGCTGACCCTGCCGCGAAGTTGCGGACAGTGCGTGAGAAACCAGCACC
  CCCTTTNCGCCGCCTCCAGCTTATGGTGAGTGTGGCTGGGGGTGCATAAAGCGCACCGGT
  ATTTCGGGGTTCTGGGGCCCCATAACCTGACCGCAGCCGGGCTCCCCGGGAGTTCCTAGA
  CACTGGTCCAAGAACTCATGCCAGTGGAACTTACACCTTCCTTGATCGGACTCGCCTTCA
  AAATTAAAGCAGACTGCCATACCTGCGTGGAATAACAAAACN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018723 unedited
  GGACCGCGGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTATTAGAATTTTTTT
  TTTTTTTAGAGTTGCTAAAATGATGTACTACTGCATGTATTGCAATACTCAGGCCTCGGA
  AAGCTTCCTTTCTCCCCACATTGGAAGGTTTTTATGGTTTTGTCATTTAGTATGGAGCAA
  AACGGTTGTATCCCCCTCGGTATATACTAGCCTGCAATGAAGAAAGAACGAGACCCACAT
  CATCAGCATGGCTCCTATTCTTGGCATCAGTCAAAGGTGCAAAAGCATTCATGGCACCAA
  CGCCGTATGTGGGGGCTGGAGCAAGTGCGTGGTGGTAGGGGTCGGCAGCATAAACTCGTC
  CGTAACTGTCACTGTAGGCAGCGGCAGTGGCAGGGGTAGGCTGGGCGTATCGGTATGCAG
  CATAACCACCATAAATGTCTGCACCATAAAATCCATCCTGGTAAACAACACCGCCGTATG
  CCGGGATCGGGGGCGGGGGCGCCGCGGCCCTGAAGGTGTTGTACACGGTGCGACCGCGGC
  CTCGCAGGTGCGCCCCTCGGTAGGCGGCCGCGGCGGTGGCTGCTGGATACGGGAAGCCTG
  GCATTGCAGAAGTATATACAAGTGAACTGGGGGCACTGTACATGGAAGATCCCTCCTGGT
  TGGCCTGGCCAACAGGACCGTGCCTGATATGATTCGGGACTGTAGACTGCACCCACAACT
  GGATTCAATTTCCAGCCATTGTATAAAGGNTTTGACGGTCTTTTTATTTGCATTACACGT
  GCTGTGGCATTATTACCCTCGATTTTACGGCCTCTACCCCGNTGCCCGTGTAATTTCTCC
  TTCGCCTGTTCGCATCGCACTATTTTTTGAAGTTACGATACCAAATCCCTTTGAGCCTCG
  CTCATTAAAAATATTTCAACTNCTAAGATTTACCNNATGACAACATGNGNCGGAGGNCCG
  ATCCCGAACCTAAGGGGGATATTGGAGACTGCANNCGCGGNCTGAACTTGNTTTTCAGTT
  TAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018723
• ORF Size: 1194 bp
• Insert Size: 2390
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_018723.2, NP_061193.2
• RefSeq Size: 2279
• RefSeq ORF: 1194
• Locus ID: 54715
• Domains: RRM
• Gene Summary: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.