PCDHA6 (NM_018909) Human Untagged Clone

CAT#: SC110568

PCDHA6 (untagged)-Human protocadherin alpha 6 (PCDHA6), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PCDHA6
• Synonyms: CNR2; CNRN2; CNRS2; CRNR2; PCDH-ALPHA6
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_018909, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGTGTTTACCCCGGAGGATAGATTGGGAAAGCAATGTCTGCTCCTCCCGCTTCTGCTCCTCGCAGCCT
  GGAAGGTGGGGAGCGGCCAGCTCCACTACTCCGTACCCGAGGAGGCCAAACACGGCACCTTCGTGGGCCG
  GATCGCGCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTGCCGCGCCTGTTCAGGATGGCCTCCAAAGAC
  CGCGAGGACCTTCTGGAGGTAAATCTGCAGAATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGG
  AGCTGTGCGGGCGGAGCGCGGAGTGCAGCATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTT
  CCATGTGGACGTGGAGGTGAGGGACATTAACGACAACCCGCCCTTGTTCCCGGTAGAGGAACAAAGAGTG
  CTGATTTACGAATCTAGGCTGCCAGATTCTGTGTTTCCACTGGAGGGCGCGTCCGATGCAGATGTTGGCT
  CAAATTCCATCTTAACCTATAAACTCAGTTCTAGCGAATACTTCGGGCTAGATGTGAAAATAAACAGTGA
  TGACAATAAACAAATTGGGCTCTTATTAAAGAAATCCTTGGACAGAGAGGAAGCTCCTGCACACAACTTA
  TTCCTGACAGCCACAGATGGGGGCAAACCTGAGCTCACAGGCACTGTTCAGCTGCTGGTCACAGTGCTGG
  ATGTGAATGATAATGCTCCCACTTTCGAACAGTCTGAATACGAAGTAAGAATATTCGAAAATGCAGACAA
  CGGAACAACAGTTATCAGACTGAATGCTTCTGATCGGGATGAAGGAGCGAATGGGGCAATTTCATATTCT
  TTTAATAGCCTTGTTGCAGCCATGGTTATTGACCACTTTAGCATAGATCGAAATACGGGAGAAATAGTGA
  TTCGGGGTAATTTGGATTTTGAACAAGAAAACTTATACAAAATCCTCATTGACGCCACGGACAAAGGCCA
  TCCTCCCATGGCGGGTCATTGCACCGTTTTAGTGAGAATTTTGGATAAAAATGATAACGTCCCTGAGATA
  GCACTGACTTCCTTATCCTTGCCTGTACGTGAAGACGCTCAATTTGGTACTGTCATCGCCCTAATTAGCG
  TGAACGACCTCGATTCAGGTGCCAACGGGCAGGTGAACTGCTCGCTGACGCCTCACGTCCCTTTCAAGCT
  GGTGTCCACCTTCAAGAATTACTACTCGTTGGTGCTGGACAGTGCCCTGGACCGCGAGAGCGTGTCGGCC
  TATGAGTTGGTGGTAACCGCGCGGGACGGGGGCTCGCCTTCGCTGTGGGCCACCGCCAGCTTGTCTGTGG
  AGGTGGCCGACATGAATGACAATGCTCCGGCGTTCGCGCAGCCCGAGTACACAGTGTTCGTGAAGGAGAA
  CAACCCGCCGGGCTGCCACATCTTCACGGTGTCTGCGCGAGACGCGGACGCGCAGGAGAACGCGCTGGTG
  TCCTACTCGCTGGTGGAGCGGCGGGTGGGCGAGCGCGCGTTGTCGAGCTACATTTCGGTGCACGCGGAGA
  GCGGCAAGGTGTACGCGCTGCAGCCGCTGGACCACGAGGAGCTAGAGCTGCTGCAGTTTCAGGTGAGCGC
  GCGCGACGCGGGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
  AACGCGCCGGCGCTGCTGGCGCCTCGGGTGGGTGGTACTGGTGGTGCAGTGAGCGAGCTGGTGCCGCGGT
  CACTGGGTGCAGGCCAAGTGGTGGCGAAGGTGCGCGCAGTTGACGCCGACTCAGGCTACAACGCGTGGCT
  TTCGTATGAGCTGCAGCCCCCGGCAAGCAGCGCTCGCTTCCCGTTTCGCGTGGGGCTGTACACGGGCGAG
  ATCAGCACCACTCGTGTCCTGGACGAAGCGGACTCTCCGCGCCACCGGCTGCTGGTGCTGGTGAAAGACC
  ACGGTGAGCCGGCGCTGACAGCGACGGCCACGGTTCTGGTGTCGCTGGTGGAGAGTGGCCAGGCTCCAAA
  GGCGTCATCACGGGCGTCGGTGGGCGCCGCGGGCCCAGAGGCGGCGCTGGTGGATGTCAACGTGTACCTG
  ATCATCGCCATCTGCGCGGTATCCAGCCTGCTGGTCCTCACGCTACTGCTGTACACAGCGCTGCGGTGCT
  CGGCGCCACCCACCGAGGGCGCGTGCACGGCGGACAAGCCCACGCTGGTGTGCTCCAGCGCAGTGGGGAG
  CTGGTCGTACTCGCAGCAGAGGCGGCAGAGGGTGTGCTCCGGGGAGGGCCCACCCAAGATGGATCTCATG
  GCCTTTAGCCCCAGCCTTTCACCTTGTCCTATTATGATGGGTAAGGCGGAGAATCAGGATTTAAATGAAG
  ATCATGATGCCAAACCACGACAGCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCA
  CAGCTCTGTGCACCTAGAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCA
  ACAGTATCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAACA
  GCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAGTTGCCCGACAA
  ATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCTACTAACAGCCAAATTGACAAA
  AGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGA
  CCCAGGAGAAAAAAGAGAAAGGGAACAGCACGACTGACAACAGTGACCAGTGA
  
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018909 unedited
  NTTTTAGCTTGNACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTAAAT
  AAATCTATGAAACAACANAACAGCGAAGGTGAGGTGTCGGGGTTTTCTTTTGCTTTTGCA
  TAAGTATTGGAAAAGGATCTGGCCTTTTCATAAACATTGTGTGCAAAAGAATTTTTAATA
  AAGTGAGCACAGGACATGTATAGGAAACACATCAGATCTGCTTCTGTTTCCCAGGGTGGT
  TCTCTGTTAAAACACTGAACTGTTGGCTTGCAGGTATGATGCAGATTTTAGGTATAATGA
  CGTCACAGCCAACAGACTTTAGGGTCTCCTAAAGCCTTGTCAGTGGGGGTAGTTTTGTCT
  CCTAGAGGGTGGCTGCCACCTCTTGAGTTGTAAGATTTAGAAAGTCTGGTCCCTTTAAGT
  TTACACTTCCCCTCCATACTGATAACTTCCGCTGTTTATTTGTCTTTGTTTTCTTGCCTT
  CCTTGTACCAATTAGTCTAAGCTGGCTCGTCTCAGCCAATATCTGGCACTCGCATACCCG
  CGGTAGCCACACATACCCAGTGGCCACAAACTCCCAAGCTGCTCAATCTCAAAACTTTTC
  AGCCTGCCCTGCAAGTGTCATCAAGACAGGATCCCCGGAGCACAGGGCAGAGAGTCCAAC
  CTCTCACTGGCGGNGCTGGGAAGCCTCTCCTTTGCGGCCGGAGAGAAAGGAAACTTGGGT
  CTGCTCTTTAAGTTCTGAAAACAAGCCCAGAGTGGAGAGAAAGAGCTAACACCAGACTTA
  GTAAAGCTTCTACCACAAAACCTGTTAAATGCGCTCTAAACAAACCCAGGGACTTTCTGC
  AAATTCCTGAGGCCTTAAAAGGGCTATGTCAAAAGGAAAAAGACCCGGACATGCCCCCTG
  GCAGACATTGCCCTTATTCAACAACTTTTAAAGGGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018909
• ORF Size: 2853 bp
• Insert Size: 3780
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_018909.2, NP_061732.1
• RefSeq Size: 5287
• RefSeq ORF: 2853
• Locus ID: 56142
• Domains: CA
• Protein Families: Secreted Protein, Transmembrane
• Gene Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) includes the constant region exons and encodes the longest isoform (1). CCDS Note: A downstream start codon is annotated for this CCDS representation because its use is more consistent with the presence of an N-terminal signal peptide in the protein, which is known to contain extracellular cadherin domains. However, it should be noted that an alternative upstream start codon exists, which would result in a protein that is 9 aa longer at the N-terminus and is less likely to contain a signal peptide. The upstream start codon has a weak Kozak signal, so it is possible that leaky scanning by ribosomes will allow the use of the downstream start codon. There is no experimental evidence indicating which start codon is used in vivo.