DIABLO (NM_019887) Human Untagged Clone

CAT#: SC110579

DIABLO (untagged)-Human diablo, IAP-binding mitochondrial protein (DIABLO), nuclear gene encoding mitochondrial protein, transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DIABLO
• Synonyms: DFNA64; SMAC
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110579 sequence for NM_019887 edited (data generated by NextGen Sequencing)
  ATGGCGGCTCTGAAGAGTTGGCTGTCGCGCAGCGTAACTTCATTCTTCAGGTACAGACAG
  TGTTTGTGTGTTCCTGTTGTGGCTAACTTTAAGAAGCGGTGTTTCTCAGAATTGATAAGA
  CCATGGCACAAAACTGTGACGATTGGCTTTGGAGTAACCCTGTGTGCGGTTCCTATTGCA
  CAGAAATCAGAGCCTCATTCCCTTAGTAGTGAAGCATTGATGAGGAGAGCAGTGTCTTTG
  GTAACAGATAGCACCTCTACCTTTCTCTCTCAGACCACATATGCGTTGATTGAAGCTATT
  ACTGAATATACTAAGGCTGTTTATACCTTAACTTCTCTTTACCGACAATATACAAGTTTA
  CTTGGGAAAATGAATTCAGAGGAGGAAGATGAAGTGTGGCAGGTGATCATAGGAGCCAGA
  GCTGAGATGACTTCAAAACACCAAGAGTACTTGAAGCTGGAAACCACTTGGATGACTGCA
  GTTGGTCTTTCAGAGATGGCAGCAGAAGCTGCATATCAAACTGGCGCAGATCAGGCCTCT
  ATAACCGCCAGGAATCACATTCAGCTGGTGAAACTGCAGGTGGAAGAGGTGCACCAGCTC
  TCCCGGAAAGCAGAAACCAAGCTGGCAGAAGCACAGATAGAAGAGCTCCGTCAGAAAACA
  CAGGAGGAAGGGGAGGAGCGGGCTGAGTCGGAGCAGGAGGCCTACCTGCGTGAGGATTGA
  
  Clone variation with respect to NM_019887.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_019887 unedited
  TTGTAATACGACTCACTTATAGGGCGGCCGCGATTCGGCACGAGGCTGGCGTCCGCGCGC
  TGCACAATGGCGGCTCTGAAGAGTTGGCTGTCGCGCAGCGTAACTTCATTCTTCAGGTAC
  AGACAGTGTTTGTGTGTTCCTGTTGTGGCTAACTTTAAGAAGCGGTGTTTCTCAGAATTG
  ATAAGACCATGGCACAAAACTGTGACGATTGGCTTTGGAGTAACCCTGTGTGCGGTTCCT
  ATTGCACAGAAATCAGAGCCTCATTCCCTTAGTAGTGAAGCATTGATGAGGAGAGCAGTG
  TCTTTGGTAACAGATAGCACCTCTACCTTTCTCTCTCAGACCACATATGCGTTGATTGAA
  GCTATTACTGAATATACTAAGGCTGTTTATACCTTAACTTCTCTTTACCGACAATATACA
  AGTTTACTTGGGAAAATGAATTCAGAGGAGGAAGATGAAGTGTGGCAGGTGATCATAGGA
  GCCAGAGCTGAGATGACTTCAAAACACCAAGAGTACTTGAAGCTGGAAACCACTTGGATG
  ACTGCAGTTGGTCTTTCAGAGATGGCAGCAGAAGCTGCATATCAAACTGGCGCAGATCAG
  GCCTCTATTACCGCCAGGAATCACATTCAGCTGGTGAAACTGCAGGTGGAAGAGGTGCAC
  CAGCTCTCCCGGNAAAGCAGAAACCAAGCTGGCAGAAGCACAGATAGAAGAGCTCCGTCA
  GAAAACACCAGANGAAGGGGAGNGAGCGGCTGANTCNNGAGCAGAGCCTACCTGCGTGAG
  GATTGAGGNCCTGACACACTGCCCTGTCTCCCACTCANTGNGAAAGCAGGGCAAATGCCA
  CCTGCCCAGGGTTGCATGACTGTCTGNGCACCGANAAAAGCNGGAGATCCTGCCTTGNNC
  ATCAGCCAGACGCCTTTTGAGCTGGGAGTGCCTCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_019887 unedited
  CTGACTTAAGCGCTGTCAAAAAGACTCCTCTCTCTGACCCAGTAGGCAAAATGCTTTGGG
  TGTGAGGTAAAAAAAATGGGTAAGAGCAGCTGTACAGAGTGGGGTGAAATGTTAAACAGG
  GTGCAGTGCCCAAGGGCTAATAACCAGGTCCAGCGCAAGCCTGATACCACAGGAGGCACT
  CACAGCTCACAAAGGCGTCTCGCCTGATTGGCCATGGCAGGATCTGCCGCCTCTTCTCGG
  TGCACATACAGTCATGCCAACCCTGGGCAGGGTGGCATCTGCCCCTGCTTTCCCCACTGA
  GTGGGGAGACAGGGCAGTGTGCTCAGGCCCTCAATCCTCACGCATGTAGGCCTCCTGCTC
  CGACTCAGCCCGCTCCTCCCCTTCCTCCTGTGTTTTCTGACGGAGCTCTTCTATCTGTGC
  TTCTGCCAGCTTGGTTTCTGCTTTCCGGGAGAGCTGGTGCACCTCTTCCACCTGCAGTTT
  CACCAGCTGAATGTGATTCCTGGCGGTTATAGAGGCCTGATCTGCGCCAGTTTGATATGC
  AGCTTCTGCTGCCATCTCTGAAAGACCAACTGCAGTCATCCAAGTGGTTTCCAGCTTCAA
  GTACTCTTGGTGTTTTGAAGTCATCTCAGCTCTGGCTCCTATGATCACCTGCCACACTTC
  ATCTTCCTCCTCTGAATTCATTTTCCCAAGTAAACTTGTTTATTGCCGGGCAAGAAGAGT
  TAAAGATTAACAGCCCTAGTTATTCAGAATAGCTCAAATAACCCATTTGTGGCCCGATAT
  ATAAAGTAAAGGGCCTTTTGTTACCAAAGACCTGNCTCCCCTATAAATGCTTAACTACTA
  AGGGAATGAAGGCTTGAATTTTGGCCATAGGAACCGACCCAAGGTTACTCCAAAACATTC
  TTCACATTTTGGCCTGGGCTTATAATTTTGAAAACACCCTTTCTATTTACCCCAACAGAA
  ACCAAATCCGGTGTGACCGAGATGAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_019887
• ORF Size: 720 bp
• Insert Size: 1200
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_019887.3, NP_063940.1
• RefSeq Size: 1498
• RefSeq ORF: 720
• Locus ID: 56616
• Protein Families: Transmembrane
• Gene Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Smac-alpha).